There is not much information about the product of biological buffer PEP on the Internet, and it is basically only limited to some basic information. There is little information about its further understanding, even if we want to understand it, we can't start. Our Desheng company is a scientific and technological enterprise integrating R & D, production and sales. We are making our own efforts in the field of biological buffer. Now, I am about PEP(CAS 35556-70-8) Some of the relevant information and you simple exchange.
||Phosphoenolpyruvic aicd Tris(cyclohexylammonium) salt
||room temperature, in dry and dark place
The role and function of biological buffer PEP (cas:35556-70-8)
PEP is a functional carbohydrate metabolite with cell protection and antioxidant activity, and may be used as a therapeutic agent for diseases involving oxidative stress. However, there was no effect at low dose (0.1, 1 mm). PEP (0.1-10 mm) also reduced cell damage, but did not decrease the intracellular ATP content induced by glycolysis inhibitor 2-deoxy-D-glucose.
PEP also reduced the leakage of aminotransferase and LDH during 72 h organ preservation, histological changes and oxidative stress parameters (measured by thiobarbituric acid reactive substances and glutathione content). The effect is comparable to that of the University of Wisconsin solution, a gold standard organ preservation agent. PEP treatment can reduce the decrease of ATP content in liver during cold storage. PEP can prevent cell damage and increase the content of ROS in HepG2 cells. In addition, PEP scavenged hydroxyl radicals, but had no effect on superoxide anion, which was evaluated by spin trapping technique of EPR.
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Desheng PEP product packaging
The cytoprotective and antioxidant properties of phosphoenolpyruvate (PEP). Phosphoric acid is a glycolytic metabolite with high-energy phosphate groups. PEP (0.1-10 mM) significantly attenuated the decrease in cell viability induced by hydrogen peroxide (H(2)O(2)) in HeLa cells in a dose-dependent manner. PEP also inhibited the decrease in cells stained with calcein-acetomethoxy and the increase in cells stained with propidium iodide induced by H(2)O(2). The increase of reactive oxygen species in cells stimulated by HEP(2)O(2) decreased significantly.
PEP is a functional carbohydrate metabolite with cytoprotective and antioxidant activities, and may be used as a therapeutic agent for diseases involving oxidative stress. However, it did not show any effect at low doses (0.1, 1 mM). PEP (0.1-10 mM) also reduced cell damage, but did not attenuate the decrease in intracellular ATP content induced by the glycolysis inhibitor 2-deoxy-D-glucose.