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9003-01-4 Carbomer Manufacturing Process,
Emulsions Carbomer Manufacturing Process,
CAS 9003-01-4 carbopol and carbomer
Carbomer production process,CAS 9003-01-4,white powder
Label: Carbomer, production process
Carbomer, also known as Carbopol, is a copolymer of polyalkyl sucrose or polyalkyl pentaerythritol and acrylic acid cross-linked polymer. It is an excellent gel matrix and has important purposes such as thickening and suspension. The process is simple. It has good stability and is widely used in emulsions, creams, and gels. It is also widely used in the pharmaceutical industry. The production process of carbomer in medicine is mainly discussed here.
Carbomer white powder
Ⅰ. Relevant technology used in tablets and capsules
●Wet granulation process
The commonly used wet granulation processes are as follows: 1. General-pass sieve method; 2． High-speed cutting method; 3. Fluidized spray granulation method; 4. Wet extrusion method.
The wet extrusion method is currently a relatively small special process used in domestic production. It is mainly used in applications with high drug loading or high particle density requirements. Usually, the materials are mixed uniformly and made with a binder. The soft material is put into the extrusion equipment, and the strip-shaped soft material is extruded, and then processed into columnar or near-circular particles with a roller granulator.
●Dry granulation process
At present, it mainly includes: 1. Dry extrusion method; 2. Heavy pressure method, etc.
Ⅱ. Granulation process of sustained-release preparations
Compared with similar types of materials such as HPMC (K4M, K15M, K100M) resin, carbomer has an obvious difference in that it has a very large swelling degree after exposure to water, which can reach a volume increase of nearly 1,000 times. In the formulation of sustained-release preparations, When the dosage of carbomer is generally greater than 8%, the wet granulation process may bring certain difficulties. In the laboratory, manual sieving and granulation are used. The dosage of carbomer can be normal even if it is close to 20%. get on. The extrusion granulation process is a very suitable process for carbomer-containing materials, especially when the proportion of carbomer materials is higher or the solid dosage form with a higher main drug content, dry extrusion granulation can avoid It gives the carbomer material the opportunity to expand, and can further improve the bulk characteristics of the particles, reduce the influence of various factors such as the selection and dosage of wetting agent on the process results, and so on. For this reason, we have carried out preliminary process exploration in this area. In the test process, the mixture of the main medicine and auxiliary medicine is first sent into a dry extruder to be extruded into flakes, and then the flakes are crushed through a screen of a certain mesh, and the dry particles obtained are then pressed according to the conventional method. The method of tablet compression, such as taking a certain nitrofuran as a model drug, investigated the influence of some factors on the drug release.
Hubei Xindesheng Material Technology Co., Ltd. specializes in providing Carbomer 940 and Carbomer 980, with high quality and good price. Customers and friends in need are welcome to consult 0711-3702650 and 18971041571.
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