Heparin sodium is a white or off-white powder with anticoagulant effect both in vivo and in vitro.It is odorless, easily soluble in water, and insoluble in organic solvents such as ethanol and acetone. It has a strong negative charge in aqueous solution and can combine with some cations to form molecular complexes. The solution of heparin sodium is relatively stable at PH 7.
There are many anti-coagulation mechanisms of heparin sodium applied in blood collection tubes, mainly by combining with antithrombin III (AT-III), inhibiting the action of coagulation factors, thereby preventing platelet aggregation and destruction, hindering the formation of thromboplastin, and preventing prothrombin from changing. It is thrombin, which prevents fibrinogen from becoming fibrin and exerts an anticoagulant effect.
Heparin sodium is often used in the collection and anti-coagulation of blood samples for clinical biochemical examinations and emergency biochemical examinations, and is also suitable for blood sample collection and anti-coagulation in some hemorheology projects.In addition to blood anti-coagulation, heparin sodium can also be used for drugs’ injection.
Heparin sodium is a mucopolysaccharide substance. After being prepared into a solution,it is easy to grow bacteria if it’s not used for a long time.Therefore, it should be used immediately after being prepared into a solution with deionized water or distilled water.Sealed and stored in a sterile state not exceed one week. Hubei New Desheng Material Technology Co., Ltd. recommends that the conventional dosage for disposable venous vacuum blood collection tubes is 5-20IU heparin sodium anti-coagulation with 1mL of blood , and 8-10IU heparin sodium anti-coagulation with 1ml blood for peripheral blood anti-coagulation. Heparin sodium on the market is generally extracted from small intestine of pigs with wide fresh supply source.The potency of heparin sodium produced by Desheng is 150IU/mg, and the anhydrous potency is 160IU/mg.The white powder obtained by refining and purification can maximize the accuracy of the experimental results.
The anti-coagulant effect is better if use heparin sodium and serum separation gel at the same time. The quality of the serum separation gel will affect the anti-coagulation effect of heparin sodium, so it is recommended to mix it with the anti-radiation separation gel produced by Desheng.
