Wuhan Desheng Biochemical Technology Co., Ltd

In the fields of biochemical testing and medical diagnosis, the chromogenic substrate TOOS (N-ethyl-N - (2-hydroxy-3-sulfopropyl) -3-methylaniline sodium salt) is an important reagent widely used in the detection of blood glucose, uric acid, liver function, and other items. However, TOOS may undergo oxidative degradation under certain conditions, which can affect the accuracy and reliability of its detection results. This article will explore in detail the causes, influencing factors, and preventive measures of TOOS oxidation deterioration. Reasons for oxidation and deterioration of TOOS The oxidative deterioration of TOOS is mainly due to its reaction with oxygen or other oxidizing substances in the air, resulting in a change in chemical structure and the loss of its original activity and color development ability. Specifically, the oxidative degradation of TOOS may be influenced by the following factors: 1. Oxygen in the air: TOOS has reducibility, and prolonged exposure to air can cause it to react with oxygen, leading to oxidation and deterioration. This oxidation reaction will alter the chemical properties of TOOS, causing it to lose its original color rendering ability. 2. Temperature: High temperatures accelerate the rate of chemical reactions, including oxidation reactions. If TOOS is exposed to high temperatures during storage or use, it will accelerate its oxidation and deterioration process. Therefore, storage temperature is an important factor affecting the stability of TOOS. 3. Humidity: Excessive humidity may cause TOOS to absorb moisture from the air, form hydrates, or undergo other chemical reactions, thereby affecting its stability and activity. 4. Light exposure: Prolonged exposure to light may cause photochemical reactions in TOOS, producing free radicals or other active substances, which can lead to oxidative degradation. 5. Impurity contamination: If TOOS is contaminated with oxidative impurities during preparation or storage, these impurities may accelerate its oxidation and deterioration process. Therefore, the purity of raw materials and the cleanliness during preparation and storage are crucial for the stability of TOOS. Factors affecting TOOS oxidation deterioration In addition to the direct causes mentioned above, the oxidative deterioration of TOOS may also be influenced by the following factors: 1. Material of storage container: Storage containers of different materials may have different effects on the stability of TOOS. For example, certain plastic containers may release harmful substances that react with TOOS, leading to oxidative deterioration. 2. Storage time: Long term storage may cause TOOS to gradually lose activity, and even under good storage conditions, oxidation and deterioration may occur due to time factors. 3. Usage: When using TOOS, improper operation, such as not preparing the solution according to the specified ratio in the manual, not fully mixing, etc., may also affect its stability and color development effect. Measures to prevent TOOS oxidation and deterioration To extend the shelf life of TOOS and maintain its activity, the following preventive measures can be taken: 1. Storage conditions: Store TOOS in a low temperature, dry, and dark environment, such as a refrigerator (recommended temperature is 2-8 ° C). Avoid prolonged exposure to high temperatures, high humidity, or light conditions. 2. Storage container: Choose a storage container with stable material and no harmful substance release, such as glass bottles or stainless steel containers. Avoid using plastic containers that may release harmful substances. 3. Ready to use: When using TOOS, the principle of ready to use should be followed to avoid color changes caused by prolonged storage. The prepared solution should be used up as soon as possible to avoid prolonged storage. 4. Raw material purity: When preparing TOOS, the purity of the raw materials should be ensured and the use of raw materials containing oxidative impurities should be avoided. At the same time, cleanliness should be maintained during preparation and storage to avoid contamination. 5. Operating standards: When using TOOS, it should be strictly prepared and used according to the proportions and operating steps specified in the instructions. Ensure that the solution is thoroughly mixed to avoid errors caused by improper operation. Conclusion The chromogenic substrate TOOS has wide applications in biochemical detection and medical diagnosis, but its oxidative degradation problem cannot be ignored. By understanding the causes, influencing factors, and preventive measures of TOOS oxidation deterioration, we can better protect its stability and activity, thereby improving the accuracy and reliability of detection. In practical applications, we should strictly adhere to storage and usage standards to ensure that the quality and performance of TOOS are fully utilized. Meanwhile, with the continuous advancement of science and technology and the emergence of new chromogenic substrates, we should actively explore and apply more stable and sensitive chromogenic substrates to meet the needs of clinical testing and scientific research. Desheng specializes in producing more than ten the new Trinder's reagents, including TOOS. After more than ten years of research and development, it can ensure that TOOS appears as a powder with a purity of up to 99.5%, strong water solubility, and stable performance to ensure the accuracy of experimental results. Desheng has a place in the market for in vitro diagnostic kit raw materials with high-quality products, and is deeply trusted and supported by customers at home and abroad. If you have any relevant intentions, please click on the official website for consultation!

In the fields of biomedical and clinical diagnosis, the chromogenic substrate TOPS reagent (N-ethyl-N - (3-sulfopropyl) -3-methylaniline sodium salt) plays an indispensable role as a key component in biochemical detection kits. Its unique chemical structure and properties enable TOPS to exhibit excellent colorimetric performance and stability in various biochemical tests, providing strong support for medical diagnosis. However, the purity of TOPS has a significant impact on the accuracy and reliability of experimental results, which cannot be ignored. 1, TOPS purity and experimental accuracy Purity is one of the important indicators for evaluating the quality of chemical substances, and for the colorimetric substrate TOPS, its purity directly affects the accuracy of biochemical detection experiments. TOPS with low purity may contain impurities, which may cause non-specific reactions with the test substance or interfere with the normal color reaction of the target substance. Specifically, if TOPS contains impurities with similar color development characteristics to the target substance, these impurities may competitively react with other components in the color development system, resulting in lower or higher measurement values of the target substance. This situation not only leads to deviations in experimental results, but may also mislead doctors' diagnostic decisions, thereby having adverse effects on patients' treatment. 2, TOPS purity and experimental stability In addition to affecting experimental accuracy, the purity of TOPS is also directly related to the stability of experimental results. TOPS with low purity may be more prone to decomposition or reaction with other substances during storage and use, resulting in decreased performance. This performance decline not only affects the stability of the current batch of experimental results, but may also cause fluctuations in experimental results between different batches or time points. This fluctuation not only increases the uncertainty of the experiment, but may also affect subsequent data analysis and conclusion judgment. Therefore, high-purity TOPS is a key factor in ensuring the consistency and reliability of experimental results. 3, TOPS purity and experimental repeatability The repeatability of experimental results is one of the important indicators for evaluating the reliability of experimental methods. Low purity TOPS may lead to reduced reproducibility of experimental results, which means that experiments may need to be repeated to verify the accuracy of the results. This not only wastes time and human resources, but also increases experimental costs. In addition, if the experimental results are inaccurate, subsequent research based on these results may also lose its significance, further increasing the risk and cost of scientific research investment. On the contrary, high-purity TOPS can reduce the variability of experimental results, improve the repeatability and reliability of experiments, thereby reducing the number and cost of repeated experiments. This is very important for both researchers and clinical diagnostic doctors. 4, TOPS Purity and Cost Control Although high-purity TOPS may mean higher production costs, in the long run, choosing high-purity TOPS is actually a more cost-effective choice. Because high-purity TOPS exhibits good stability during storage and use, with longer shelf life and better stability. This means that the waste of reagents and the cost of repeated experiments caused by performance degradation can be reduced. In addition, high-purity TOPS can improve the accuracy and reliability of experimental results, reducing the risk of misdiagnosis and mistreatment caused by inaccurate experimental results. All of these can provide patients with more accurate and reliable diagnostic services, improving the quality and efficiency of medical care. 5, Conclusion In summary, the purity of the chromogenic substrate TOPS has a significant impact on the accuracy and reliability of experimental results. High purity TOPS can not only improve the accuracy and stability of experimental results, but also reduce experimental costs and risks. Therefore, when selecting and using TOPS, priority should be given to its purity to ensure the accuracy and reliability of experimental results. Meanwhile, by optimizing raw material selection, synthesis process, purification steps, and quality control strategies, the purity of TOPS can be further improved to meet the needs of scientific research and clinical diagnosis. Desheng specializes in producing more than ten the new Trinder's reagents, including TOPS. After more than ten years of research and development, it can ensure that TOPS appears as a powder with a purity of up to 99.5%, strong water solubility, and stable performance to ensure the accuracy of experimental results. Desheng has a place in the market for in vitro diagnostic kit raw materials with high-quality products, and is deeply trusted and supported by customers at home and abroad. If you have any relevant intentions, please click on the official website for consultation!

In the rapidly developing field of in vitro diagnostics (IVD), every technological innovation and breakthrough means that the industry is moving towards more efficient and accurate diagnosis. In 2025, as the global IVD industry elite focuses on China, a grand event that gathers wisdom and innovation - the China International Clinical Laboratory Equipment and Supplies Exhibition (CACLP) - is about to kick off. At this annual feast, Hubei Xindesheng Material Technology Co., Ltd. (hereinafter referred to as "Xindesheng") sincerely invites every colleague dedicated to the field of in vitro diagnostics to join hands, explore the future, and promote the prosperous development of the IVD industry. Innovation leads, jointly building the future of IVD As a member of the IVD industry, Xindesheng has always adhered to innovation driven development and production of in vitro diagnostic reagents since its establishment. Our product line covers multiple fields such as blood collection tube additives, biological buffering agents, chemiluminescence reagents, chromogenic substrates, enzyme preparations, etc., aiming to provide comprehensive reagents for clinical diagnosis. At the upcoming CACLP exhibition, Xindesheng will bring a series of latest research and development achievements, including high-sensitivity detection reagents. These innovative products not only improve the accuracy and speed of diagnosis, but also provide strong support for clinical decision-making. Technical exchange, exploring the forefront of the industry together CACLP is not only a platform for showcasing new products, but also a bridge for deep communication and cooperation within the industry. Xindesheng is well aware that open sharing of technology is the key to promoting industry progress. Therefore, we have set up a special exchange area to have in-depth discussions with our peers attending the exhibition on the latest trends, technological challenges, regulatory policies, and other hot topics in the field of IVD. In addition, the technical team of New Desheng will also answer participants' questions on site, share our valuable experience in product research and development, production quality control, etc., and promote the barrier free flow of knowledge and technology. Collaboration Bridge, Seeking Global Development Together In the context of globalization, international cooperation in the IVD industry is becoming increasingly important. With years of experience in international market development, Xindesheng has established a sales network covering multiple countries and regions such as Asia, Europe, and the Americas. During the CACLP exhibition, we look forward to face-to-face communication with partners from all over the world to explore cooperation opportunities. Whether it is raw material supply, technological upgrading, market expansion, or joint research and development, Xindesheng is willing to serve as a bridge to promote the deep integration of the global IVD industry chain, jointly respond to market challenges, and share development opportunities. Take responsibility and build a healthy future together While pursuing technological innovation and commercial success, Xindesheng never forgets its corporate social responsibility. We are well aware that high-quality in vitro diagnostic reagents have immeasurable value in improving public health and safeguarding people's health. Therefore, Xindesheng has always been committed to improving product quality, following the highest international standards, and ensuring that every reagent can accurately and safely serve clinical use. At the CACLP exhibition, we will showcase our efforts and achievements in quality control, environmentally friendly production, and call on more peers to join this noble mission and contribute to building a community with a shared future for human health. Conclusion: Hand in hand, create brilliance together CACLP in 2025 is not only an exhibition, but also a collision of ideas and a fusion of wisdom. Xindesheng sincerely invites every colleague in the IVD industry, whether you are industry veterans, technical experts, or entrepreneurs of emerging enterprises, to visit our booth (booth number: 4-A 0003), so that we can inspire inspiration through face-to-face communication and create brilliance through cooperation. Let's join hands and write our own wonderful chapter on the global IVD stage!

Carbomers are effective at increasing viscosity in aqueous systems at relatively low levels, with most carbomers capable of producing viscosities of 10,000–60,000 cP when used at only 0.5% w/w. Therefore, carbomers are commonly used as aqueous thickeners in various products. However, the real use of carbomer lies in its ability to impart high yield values ​​to formulations. Yield value is the resistance of a fluid to initial flow when stress is applied, and at rest, a tightly packed carbomer microgel network behaves as an elastic solid that resists deformation. The network does not begin to flow until a critical level of shear stress (i.e. yield stress) is applied, at which point the microgels can slide past each other, resulting in fluid flow. When heterogeneous phases, such as emulsion droplets, are dispersed in a carbomer-thickened formulation, the microgel network captures and stabilizes them against fluids at rest, ie, below the yield stress. However, when a stress in excess of the yield stress is applied, the fluid flows smoothly, enabling product dispensing and application. For this reason, carbomer is used to formulate countless products. Carbomer is easily dispersed in water and mixtures of polar organic solvents and water, such as 70% w/w ethanol-water. When initially prepared, aqueous dispersions of hydrated carbomer particles are acidic and typically exhibit a pH of 2.5-3.5, depending on the polymer concentration. These dispersions do not have significant viscosity and may be cloudy prior to neutralization with alkaline pH adjusters such as sodium hydroxide or triethanolamine. After neutralization of the carboxylate groups, the carbomer becomes ionized and expands to hundreds of its original volume due to electrostatic repulsion between the negatively charged carboxylate groups and osmotic expansion due to trapped counterions times to obtain a microgel dispersion. Hubei Xindesheng Material Technology Co., Ltd. is a professional manufacturer of carbomer. It has a professional carbomer R&D and production team with 17 years of experience and rich product knowledge. There are 940 and 980 models of Carbomer currently produced. The product has stable performance and good use effect. Free samples can be provided for a small test, if you need to buy, please feel free to inquire and buy!