In chemiluminescence immunoassay experiments, there are two types: plate and tube. Among them, tube chemiluminescence will use magnetic beads as a carrier for adsorbing acridinium ester-labeled antibodies or proteins to facilitate the washing and separation of labeled antibodies. The magnetic beads here are a kind of magnetic biological microspheres, which are nanomaterials. In fact, there are many types of nanomaterials in the in vitro diagnostic reagent industry.
The magnetic beads newly developed by the company are different from the original serum separation gel and high molecular polymer materials such as carbomer. Magnetic beads are a kind of more advanced nano materials. Because nanomaterials have unique optical, magnetic, electrical and thermal properties, they can be used to generate different types of detection signals, amplify the intensity of detection signals, and simplify the detection process. Therefore, in vitro diagnostic technology based on nanomaterials has broad application prospects. Nanomaterials can be applied to the detection of nucleic acids, proteins, small molecules, bacteria and viruses.
In Vitro Diagnostic Reagents and Magnetic Bead Materials
With the rapid development of clinical medicine diagnosis and treatment technology, many traditional and conventional in vitro diagnostic technologies can no longer meet the needs of clinical medicine development. People have higher and higher requirements for the sensitivity, accuracy and specificity of clinical diagnostic analysis. Therefore, nanomaterials Also came into being. In particular, because nanomaterials have a much higher specific surface area than macroscopic materials, they can provide a lot of space to modify different molecules on their surfaces, making them play an important role in applications such as bioanalysis and biosensors. Using these surface-modified nanomaterials with different molecules can selectively detect small molecules, nucleic acids, proteins and microorganisms.
There are many different types of nanomaterials, such as semiconductor quantum dots, gold nanoparticles, and magnetic nanoparticles. Among them, magnetic beads are a kind of magnetic nanoparticles, which are widely used in the field of in vitro diagnostic reagents. Nanomaterials can be used for the detection of nucleic acids and antibody proteins in chemiluminescence immunity according to different types; some can be used for enzyme-linked immunosorbent assay (ELISA) immunoassays and DNA microarray detection, etc.; others are used for tumor cell detection and bacteria Detection, virus detection, and tracing of small molecule drugs in living cells, etc., have a very broad application prospects.
In the past, acridine esters chemiluminescence reagents mainly relied on imports. Now, due to the good market feedback of the acridine esters developed by Desheng, the magnetic bead materials developed are mainly used for chemiluminescence experiments. Other in vitro diagnostics will be considered later. Application in experiment.
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