Difference between heparin and heparin sodium
The anticoagulant heparin sodium, as a blood processing reagent, is highly valued in clinical practice due to its significant anticoagulant effect when in contact with blood samples. Although many people are proficient in its operating procedures, as a non irreversible anticoagulant reagent, attention should also be paid to the duration of action during use. Below, we will provide a detailed introduction around this point.
The mechanism of action of anticoagulant heparin sodium
Its mechanism of action is mainly through binding with coagulation factors II and VII in the blood, inhibiting the activity of coagulation factors, thereby preventing the formation of thrombin and achieving the goal of inhibiting blood coagulation. Because other factors have effects on the three stages of coagulation process, they have anticoagulant effects both in vivo and in vitro. In vivo, they mainly activate the endogenous fibrinolysis system, promote the dissolution of thrombus, and prevent thrombotic diseases.
The action time of heparin sodium
Heparin sodium can be classified into drug grade and analytical grade, and the duration of action of drug grade heparin sodium varies depending on individual differences, dosage, disease status, and other factors.
1. Drug grade heparin sodium: Generally speaking, its action time is about 2-3 hours, which is the time required for the drug concentration to decrease to half. In some special cases, such as prolonged use of heparin sodium during surgery, doctors will adjust the dosage and duration of medication according to the specific situation to achieve the best treatment effect.
2. Analysis of pure grade heparin sodium: It mainly acts in blood collection vessels. As anticoagulation is non irreversible, the heparin sodium anticoagulant tube should be tested within 6 hours after blood collection. This means that its action time is 6 hours, and if it exceeds 6 hours, there may be errors in the test results.
Precautions for using heparin sodium
1. When using the drug heparin sodium, in order to control the duration of the drug's action, it is necessary to adjust and monitor the dosage according to the specific situation of the patient. Before blood collection or transfusion, medical staff need to assess the patient's bleeding risk and coagulation function status, and provide appropriate doses of heparin sodium as needed.
2. When using the extracorporeal anticoagulant heparin sodium, it is necessary to ensure that the blood sample is fully anticoagulated. After blood collection, medical staff must quickly mix it upside down 5-8 times, especially when the blood collection temperature is high. If anticoagulation is not sufficient, it can easily lead to local coagulation.
3. Heparin anticoagulation is involved in the metabolism of cellular enzymes and ions, and its dosage can affect the detection results. Therefore, both in vivo and in vitro anticoagulation should pay attention to their respective dosage. For example, the recommended dosage range for blood sampling is 12-30IU of heparin sodium per milliliter of blood, and for micro blood sampling, anticoagulation can be less than 14IU. Only by using according to the standard can the safety and effectiveness of use be guaranteed.
As a professional manufacturer of heparin sodium, Desheng's products are all analytical grade raw materials, which are added to test tubes after preparation and are not related to drug grade heparin sodium. When purchasing, everyone needs to indicate their needs in advance so that customer service can better serve you. Welcome to contact us for purchase!
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