Heparin sodium and heparin lithium are two common anticoagulants that play important roles in clinical and laboratory applications. Although they are very similar in terms of names and the raw materials are in powder form, they are prepared into solutions and added to test tubes for use, but there are significant differences in chemical properties and some specific applications. Let's take a look together.
Different chemical properties
1. Different nuclear charge numbers: One of the biggest differences between heparin sodium and heparin lithium is that they contain different metal ions. Sodium heparin contains sodium ions (Na+), while lithium heparin contains lithium ions (Li+). Lithium ions have a lower nuclear charge than sodium, making them more chemically stable.
2. Differences in coagulation speed: Due to the different nuclear charge numbers between heparin lithium and heparin sodium, the interaction speed between heparin lithium and platelets (PLT) is slow. In contrast, the binding speed between heparin sodium and PLT is relatively fast, which may be unfavorable for certain laboratory applications. For example, heparin sodium is not suitable for whole blood cell analysis, as the faster aggregation speed of PLT may lead to inaccurate results.
Differences in binding mechanisms
Both heparin sodium and heparin lithium are different forms of heparin, but their binding mechanisms differ. Heparin lithium can be understood as being replaced from heparin sodium, so their effective binding ions are different.
The recommended dosage is different
In the industry standards for vacuum blood collection, there are different dosage ranges for heparin sodium and heparin lithium. Normally, there is 12-30IU of heparin sodium per milliliter of blood, but the recommended dosage range for heparin lithium is usually between 9.4IU-28IU per milliliter of blood. This difference needs to be considered in the laboratory and blood collection process to ensure the correct anticoagulant effect.
From the above, there are significant differences between heparin sodium and heparin lithium, especially in terms of chemical properties, binding mechanisms, and anticoagulant dosage. When using, attention should be paid to selecting test tubes that meet experimental requirements for blood collection or experimentation to ensure safety and effectiveness. As a manufacturer of blood vessel additives, Desheng can supply high-quality and reliable raw materials. Due to its independent warehouse, it can store in stock, and customers do not need to worry about shortages and low prices. If you have any interest, please feel free to contact us for purchase!
