Anticoagulant is a kind of reagent commonly used in medical and biological fields to prevent blood coagulation. Among them, pig heparin and heparin sodium are very common in the market. Although they appear similar on the surface, there are certain differences in structure, source, characteristics, and application. Below, we will compare and analyze pig heparin and heparin sodium to help you further understand the differences between the two.
1、 Structure and Source
Hoggarin is a natural polysaccharide Anticoagulant, which is mainly extracted from pig intestinal mucosa. Its main component is a mixture of heparin sulfate and other sulfate polysaccharides. Heparin sodium is a synthetic Anticoagulant, and its structure is similar to natural heparin. But its preparation is generally achieved by extracting heparin from animal (such as pig) mucosa, and then chemically modifying and refining it.
2、 Molecular weight and properties
The molecular weight of pig heparin is relatively large, usually ranging from 3000 to 30000 Daltons. It has anticoagulant activity and can inhibit coagulation reactions by forming complexes with coagulation factors and antithrombin. However, the molecular weight of heparin sodium is relatively small, usually around 15000 Daltons. However, it also has anticoagulant activity, usually by forming a complex with thrombin to block the coagulation process.
3、 Anticoagulant mechanism
Porcine heparin blocks the activity of thrombin by binding to thrombin and coagulation factor Xa, thereby inhibiting blood coagulation. Heparin sodium plays an anticoagulant role mainly by combining with thrombin and antithrombin III (AT-III). It can improve the anticoagulant activity of AT-III and inhibit the formation of thrombin.
4、 Application field
Porcine heparin is mainly used in cardiovascular surgery, dialysis treatment, and the prevention and treatment of thrombotic diseases. It is also used as a Anticoagulant in laboratory research. Heparin sodium is usually used as extracorporeal blood Anticoagulant in blood collection vessels, and is suitable for liver and kidney function testing, blood glucose and routine biochemical testing.
Although both porcine heparin and heparin sodium are Anticoagulant, they are different in structure, source, characteristics and application. The choice of anticoagulant to use should be based on actual needs, and attention should be paid to the amount used during the use process. Excessive or insufficient use can have an impact on the experimental results. As a professional supplier of heparin sodium, Desheng produces products with analytical purity, which can be added to test tubes for use as extracorporeal blood Anticoagulant. After strict quality control and testing, it ensures compliance with customer standards and requirements, and is deeply trusted and praised by customers. If you are interested, please feel free to contact us for purchase!
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