Heparin lithium heparin sodium is a common heparin blood anticoagulant additive for heparin tubes. This year, customers who purchased lithium heparin have reported some questions to our company. For example, the doctor was using heparin tube to manipulate blood for electrolyte analysis and found that blood potassium and blood sodium were higher than the normal reference value. Why? After receiving the customer's feedback, we first performed repeated tests on the same batch of lithium heparin produced by our company, and determined that the various indicators are normal. We plan to explore the answer from two aspects. One is to find the conclusions of experts on the Internet, and to explore the answer from the doctor's professional point of view.
10g each bottle of lithium heparin packaging
According to the examination of lithium heparin medical and clinical literature, the problem was found. By comparing the results of electrolyte measurement with lithium heparin anticoagulated plasma and serum without heparin substances, the mapping of lithium heparin to electrolyte measurement is analyzed. The method used is to draw 2 specimens of the same sample with different additives at the same time, a total of 40 specimens for comparison. The results of the experiment show that the anticoagulant effect of lithium heparin has a significant effect on the determination of blood potassium, and there is no statistically significant trend in the difference in the determination of blood sodium and blood chlorine. It is recommended that the electrolyte determination is better to absorb non-anticoagulated specimens.
Analyzing the results of the study, Lunan found that compared with the serum electrolyte without heparin, heparin has no effect on the determination of blood sodium and blood chloride, but has an effect on blood potassium. Lithium heparin anticoagulant has a significant interference effect on potassium levels in electrolyte determination. From the analysis of the reason, heparin substance and potassium produce potassium heparin, which interferes with the determination of potassium by the ion-selective electrode, resulting in lower potassium ion content in the blood.
At the same time, for serum samples, due to the destruction of platelets during the process of blood aggregation, potassium ions in the platelets (the concentration of which is much greater than that of plasma potassium) are released from human blood, making the serum concentration higher than that of plasma potassium ions, and the degree of increase is related to the number of platelets. In a positive relationship. In the practice of evacuation of serum, the true level of potassium in the body cannot be accurately reflected due to the fragmentation of platelets. Plasma potassium is used to replace the determination of serum potassium.
According to common clinical experience, although there is interference from platelet destruction, serum potassium is still in view of the determination of plasma potassium, because blood serum potassium has no heparin influence, and the old domestic biochemical analysis and analysis widely accept serum as a specimen. From the perspective of professional doctors' clinical practice experience, this conclusion is also created. Heparin lithium heparin sodium is the heparin product represented by the main reaction reagent. After blood sampling, the anticoagulant reagent has a significant effect. Complete blood count and blood cell examination are often designed.
Desheng Biochemical is deeply engaged in the field of blood collection tube preparations, and its products cover serum separation gel, heparin sodium, lithium heparin, dipotassium EDTA, tripotassium EDTA, coagulant, siliconizing agent, sodium citrate, potassium oxalate. 22 self-developed patented technology blessings. Ensure that the products that customers get are better than the average products of the peers, and enjoy high-quality after-sales technical services.
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