Anticoagulants are a type of reagent used for blood processing, which can delay blood clotting and help medical staff fully apply it to various biochemical tests. Heparin lithium, as a polysaccharide compound, is usually extracted from animal organs (such as pig intestinal mucosa), with an average molecular weight of around 15000 and a negative charge, which is one of its key characteristics as an anticoagulant. Below is a specific introduction to how heparin lithium acts as an anticoagulant.
The anticoagulant mechanism of heparin lithium
The anticoagulant effect of heparin lithium involves multiple mechanisms, which together ensure its anticoagulant effect:
1. Inhibition of the formation of prothrombin kinase: Heparin lithium binds to antithrombin III (AT - III) to form the heparin AT - III complex. AT - III is a serine protease inhibitor that can inactivate coagulation factors with serine protease activity, while heparin lithium promotes coagulation factor inactivation by enhancing the activity of AT - III, thereby inhibiting the formation of prothrombin kinase.
2.Interference with the function of thrombin: When it binds to AT - III, it blocks the normal activity of thrombin and further inhibits the conversion of fibrinogen to fibrin. At the same time, it can also block platelet adhesion and aggregation, thereby preventing platelet disintegration and releasing platelet factors and serotonin.
Advantages of heparin lithium anticoagulants
Compared with other anticoagulants, heparin lithium has its own unique characteristics and advantages:
1. Rapid anticoagulation: The anticoagulation effect of heparin lithium occurs immediately after contact with blood samples, making samples that urgently require anticoagulation treatment suitable for various biochemical testing items without the need for prolonged waiting.
2. Low monitoring demand: The anticoagulant effect of heparin lithium is relatively stable, and frequent observation of blood samples is usually not necessary.
3. Widely applicable: It can be used in various situations, such as liver and kidney function measurement, as well as in the diagnosis of deep vein thrombosis, pulmonary embolism, DIC and other coagulation diseases.
As an anticoagulant, heparin lithium has a wide range of applications in the medical field, and its unique anticoagulant mechanism makes it a powerful tool for dealing with various coagulation problems. As a manufacturer of heparin lithium, Desheng can provide high-quality raw material powder, which is prepared into a solution and added to the blood collection vessel for use. It not only plays a stable role, but also has a favorable raw material price! If you have any interest, please feel free to contact us for purchase!
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