The role of tris(hydroxymethyl)aminomethane TRIS in the treatment of hyperuricemia

The full name of Tris is tris(hydroxymethyl)aminomethane, which can also be called tromethamine, CAS77-86-1. Tris (Tris) is often used as a biological buffer, and TAE and TBE buffers (used for the dissolution of nucleic acids) commonly used in biochemical experiments are required. What other applications does it have besides this? Let's take a look next.

In the field of medicine, Tris is not only an important pharmaceutical intermediate, it is also a kind of drug itself, suitable for metabolic acidemia, respiratory acidemia and other diseases, especially in hyperuricemia. In terms of treatment, the effect is relatively satisfactory.

Hyperuricemia is divided into two categories: primary hyperuricemia and secondary hyperuricemia, mainly due to excessive sources of uric acid or (and) insufficient excretion. Under normal circumstances, if the two fasting blood on the same day is not the same, the uric acid level of men is higher than 420μmol/L, and women's uric acid level is higher than 360μmol/L, which is hyperuricemia. According to social understanding, the age of high incidence of hyperuricemia is middle-aged and old men and postmenopausal women. In recent years, there is a trend of getting younger.

The current prevention and treatment strategies for hyperuricemia include reducing intake, inhibiting endogenous synthesis, and promoting renal excretion. The promotion of renal excretion is mainly achieved by alkalizing urine and inhibiting uric acid transporters. Inorganic metal cations in urine such as Ca2+, Mg2+, NH4+, etc. can inhibit the dissolution and excretion of uric acid, and alkaline factors can promote the dissolution of uric acid, so tris and sodium bicarbonate are often used in this process. But in the function of promoting uric acid dissolution and excretion, the effect of tris is better than sodium bicarbonate.

After taking sodium bicarbonate, the increased cation Na+ will further resist HCO3- alkalizing urine and blood, and promote the dissolution and excretion of uric acid. Sodium bicarbonate will even reduce the solubility of uric acid after a certain dose. However, sodium bicarbonate can be produced endogenously. There is sodium bicarbonate in the human body, and there are large fluctuations in the urine, so the concentration of sodium bicarbonate is difficult to control. If the amount of sodium bicarbonate is small, uric acid will be excreted. The effect is not good. If you take more, it may increase the deposition of uric acid in the urinary system, and the intake of sodium salt will also increase the burden on the cardiovascular and kidneys.

Tris is an organic amino base. There are no inorganic cations, which can avoid or weaken the inhibitory effect of inorganic cations. In addition, Tris is a foreign substance and the body will not produce tris. As a methane substance, the concentration of tris in the body is better controlled than sodium bicarbonate in the process of medication. In summary, it can be concluded that tris is better than sodium bicarbonate in promoting the dissolution of uric acid.

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