The full name of TOPS (CAS No.:40567-80-4) is N-ethyl-N-(3-sulfopropyl) -3-methylaniline sodium salt, which is a white to light brown powder, also a member of the new Trinder's reagent family. Maybe you think the name sounds humongous, and it is a vocabulary that a fully professional pharmacist only understands. It is even more difficult to relate to your life. If you think so, you are wrong. You may not have heard of this name, but I think most of you or people around you have done biochemical tests in the hospital, that is, liver function, kidney function, uric acid, cholesterol and other tests. Most of these tests are carried out by automatic biochemical analyzers, uric acid analyzers, etc. in conjunction with the corresponding kits. And one of the core raw materials in these kits is the TOPS we talk about today.
In humans and primates, uric acid is the final product of purine metabolism. It is produced by the oxidation of xanthine and hypoxanthine by xanthine oxidase and is excreted in the urine. High serum uric acid and hyperuricemia are associated with insulin resistance, cardiovascular disease and gout. The mechanism leading to hyperuricemia is usually increased uric acid production or decreased urine excretion. Increased serum uric acid may be a sign of kidney disease, so the early diagnosis of kidney disease can be indirectly through the test of uric acid.
|Chinses name||N-ethyl-N- (3-sulfopropyl) -3-methylaniline sodium salt|
|English name||Sodium 3-(N-ethyl-3-methylanilino)propanesulfonate|
|Molecular formula||C12H18NNaO3S, H2O|
|Appearance||White or light brown powder|
|Storage condition||0-5℃，away from light and moisture|
|Transport condition||Room temperature（20-25℃）|
|Maximum absorption wavelength||550 nm|
|Applacation||This product is used for the colorimetric determination of uric acid and cholesterol. It has the characteristics of good water solubility, high sensitivity and strong stability. Cholesterol colorimetric determination; water-soluble reagent, used for catalase photometric determination.|
In the presence of hydrogen peroxide and peroxidase, TOPS reagent is formed during the oxidative coupling reaction with 4-aminoantipyrine (4-AA) or 3-methylbenzothiazolone hydrazone (MBTH) Very stable purple or blue dye. The substrate is enzymatically oxidized by its oxidase to produce hydrogen peroxide. The concentration of hydrogen peroxide corresponds to the substrate concentration. Therefore, the amount of the substrate can be determined by the color development of the oxidative coupling reaction to obtain a relatively accurate test result of the concentration of the analyte. TOPS produced by Desheng has obtained the quality certification of more than 100 manufacturers nationwide. Because of its color rendering sensitivity, color stability and anti-interference, as well as the accuracy and precision of specific measurement items, it has been well received by customers. You are welcome to inquire, the company will provide you with quality products and excellent services, so that your products rank among the industry's leading level! Company website: https://www.vacutaineradditives.com, Phone No.: +86-711-3702650.
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