Why are EDTA K2 and EDTA K3 anticoagulants of choice in routine hematology？

    In the routine blood testing, various medical institutions mostly use vascular additives and supporting equipment and instruments for analysis, more common additives are anticoagulant, coagulant promoting agent, serum separation glue, etc. In terms of market application, there are many types of anticoagulant products, such as EDTA K2 and EDTA K3, which are widely used. Why are these two reagents so popular? The following details for you to introduce.

    What are EDTA K2 and EDTA K3?

    EDTA K2 is a strong anticoagulant commonly used to store blood in blood collection tubes, which can stop blood clotting for a certain amount of time. Its mechanism is because of its chelation property, after full contact with blood in test tubes, it can achieve the purpose of trapping metal ions, thus reducing reactivity at the root and preventing blood clotting. Speaking of EDTA K3, in fact, it is another form of EDTA K2. Its performance and action mechanism are the same, that is, it has one more potassium ion than EDTA K2 in the number of ions.

    Why are EDTA K2 and EDTA K3 commonly used anticoagulants?

    The main reasons for the use of EDTA K2 and EDTA K3 as anticoagulants in routine blood tests are:

    1. Both of them are anticoagulant by chelating potassium ions;

    2, both play a role in preventing the blood stored in the tube from clotting, both can be achieved by chelating the calcium ions of the blood;

    3, Both are approved by the International Blood Committee in vitro blood anticoagulants, suitable for common routine blood test analysis, thus complete blood count;

    Use points when selecting EDTA K2 and EDTA K3

    1. First of all, it is important to determine the blood collection volume and the dosage of EDTA K2 or EDTA K3. Usually, the blood collection volume is 2mL and the anticoagulant dosage is 20uL.

    2. Since the produced EDTA K2 and EDTA K3 are in powder form, they need to be configured as solution. It should be noted that the storage condition of the solvent should be kept at 0-4℃ and the storage time should not exceed one week.

    3. When using EDTA K2 or EDTA K3 anticoagulant tubes for blood collection, it should be noted that the anticoagulation of EDTA salt is not irreversible anticoagulation, and the detection should be completed within 24 hours after blood collection.

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