The density of serum separation gel is between serum and blood cells. During centrifugation, it changes from solid to liquid through thixotropy and migrates to form an isolation layer between the two. After centrifugation, it returns to solid state to prevent mixing. It has stable chemical properties and is often used in combination with coagulants to accelerate coagulation. Pure serum can be obtained in one step by centrifugation, reducing contamination errors. It is widely used in clinical biochemistry and immune testing.