Heparin is common in clinical blood test with sodium salt and lithium salt, which has unique application value. Heparin has low chelating force, little influence on the movement of water molecules, less interference on blood components, no influence on the volume of red blood cells, and no hemolysis. Therefore, heparin is recommended as an anticoagulant in a variety of tests based on whole blood or plasma.
Heparin lithium and heparin sodium have anticoagulant effects in clinic. They are mainly used in thromboembolic diseases, myocardial infarction, cardiovascular surgery, cardiac catheterization, extracorporeal circulation, hemodialysis and so on. Because of the different ions combined, their dissociation degree is different. The effect of heparin lithium is better than that of heparin sodium.
In the detection of pH value, blood gas, electrolyte and calcium ion, heparin is the only anticoagulant that can be used, and heparin lithium has the least possibility of interference in the detection of non lithium ion, so heparin lithium is recommended as anticoagulant. At present, heparin lithium is gradually replacing heparin sodium in blood test.
It is used for biochemical test of patients after hemodialysis
The blood sample of patients after hemodialysis is a kind of special sample that many hospital laboratory departments have to face. Many inspectors often feel helpless when facing such samples. This is because hemodialysis patients use anticoagulant drugs containing heparin, such as low molecular weight heparin calcium, etc. at this time, because there is a certain amount of heparin anticoagulant drugs in the blood, it is very difficult to coagulate and separate the blood after the blood is extracted and placed in the common tube or separation gel / coagulant tube.
It has been reported that there is bias in the analysis of blood K detected by heparin lithium anticoagulant plasma and serum, which may be caused by the high rotation speed of blood sample during centrifugation, the destruction and hemolysis of red blood cells in fibrin clot, and the release of K ions in red blood cells into serum. In addition, a small amount of red blood cell damage is inevitable in the process of transportation and coagulation of blood samples, resulting in slightly high blood K.
In addition, the results of CK-MB, LDH and Glu detected by heparin lithium anticoagulant plasma and serum were significantly different, which may be due to hemolysis or decomposing blood glucose after long storage. On the contrary, heparin anticoagulant does not affect the cell volume and is not easy to cause hemolysis. It does not need to be placed in a water bath and can be directly centrifuged. The blood K, Glu and LDH measured by heparin lithium anticoagulant plasma are more close to the real concentration of patients. Therefore, establishing the reference value system of plasma biochemical test as soon as possible is helpful for clinicians to make accurate judgment on patients' condition.
Used for routine biochemical test
The results showed that heparin lithium anticoagulant plasma could be used to replace serum in most routine biochemical tests, but the reference range of Glu, K +, Na +, CI -, P3 - should be established, and the reference range of serum could be used to explain the results of plasma test in other items; LP (a), PA, HBDH, LDH, CK, CKMB, IgM and other items should not be measured with heparin lithium anticoagulant plasma samples, and the change of plasma Lp (a) with heparin concentration It increases with the increase of temperature.
Desheng has been engaged in the R & D and production of blood collection additives for 15 years. It can be said that Desheng is an old manufacturer of blood collection additives. Heparin sodium and heparin lithium are our main products. They are non injection grade. They are mainly used as anticoagulants in blood collection additives, that is, in vitro anticoagulants. They are recommended and purchased by many companies. Moreover, we can also customize heparin products with potency of 150iu-180iu according to the needs of customers.
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