Heparin sodium can be extracted from small intestine mucosa and lung tissue of pigs, cattle and sheep. However, the application of heparin sodium from cattle is limited due to the appearance of BSE.
Studies have found that heparin sodium from different sources has different chemical structure and biological activity, and its adverse reactions are also different. The adverse reaction of thrombocytopenia induced by heparin sodium from cattle is about twice as much as that caused by heparin sodium from pig, which leads to the requirements and restrictions of raw material sources in various countries. It is safer to use heparin sodium from pig.
In the newly developed low molecular weight heparin (LMWH) and ultra-low molecular weight heparin (ULMWH) products, most of the heparin sodium is required to come from pig intestinal mucosa. Studies have shown that the structure of heparin sodium from pig is the same as that of human endogenous heparin sodium.
Heparin sodium is one of the most important biochemical drugs exported in China, accounting for more than 55% of the world's production. The control of raw material source and quality is the key to the long-term development of heparin sodium in the international market.
At present, foreign manufacturers do not purchase heparin sodium from cattle, goats and sheep, but only purchase heparin sodium from pigs in order to prevent mad cow disease and pruritus. Heparin sodium mixed with bovine, goat and sheep is regarded as unqualified product, so it is important to distinguish heparin sodium from different species.
At present, there are many ways to detect heparin sodium from different sources, such as PCR (polymerase chain reaction), NMR (nuclear magnetic resonance), ESI MS (electrospray ionization mass spectrometry), but these methods are usually expensive, and the detection steps are cumbersome and complex. Based on this, it is particularly important to find a simple and quick way to distinguish heparin sodium from different sources. Heparin sodium from different species was hydrolyzed by enzyme, and its disaccharide composition was analyzed by anion exchange high performance liquid chromatography (sax-hplc).
Desheng is a professional manufacturer of blood collection reagent, with more than ten years of research and development, production experience, perfect quality detection and quality assurance system. Its heparin sodium comes from pig intestinal mucosa, mainly used as blood collection additive. Heparin sodium has good anticoagulant effect, effective price ≥ 150IU, high purity, fast delivery, welcome to consult and order!
Contact Person: Miss. Ankiwang