Does blood anticoagulant heparin sodium / heparin lithium affect the results of blood potassium and blood sodium?

Heparin lithium heparin sodium is a common additive for heparin tubes. This year, customers who purchased heparin lithium reported some problems to our company. For example, the doctor used heparin tube to operate blood for electrolyte analysis, and found that blood potassium and blood sodium were on the high side. Why? After receiving the customer's feedback, we first conducted repeated tests on the same batch of heparin lithium produced by our company to determine that its various indicators are normal. We plan to explore the answer from two aspects. One is to find the implementation conclusion of experts on the Internet and explore the answer from the professional perspective of doctors.

10g heparin lithium package per bottle

The problem was found according to the medical and clinical literature. The effect of heparin lithium on the determination of electrolyte was understood by comparing the results of plasma anticoagulated with heparin lithium and serum without anticoagulant. The method used is to select two samples of different additives of the same object at the same time, a total of 40 samples for comparison. The results showed that heparin lithium anticoagulant had a significant effect on the determination of blood potassium, but there was no significant difference in the determination of blood sodium and blood chlorine. The experimental conclusion is that heparin lithium has an effect on the determination of blood potassium. It is suggested that non anticoagulant samples should be used for the determination of electrolyte.

The results showed that compared with serum without anticoagulant, heparin had no effect on the determination of blood sodium and blood chlorine, but there was a difference in blood potassium. Heparin lithium anticoagulant has a significant effect on the level of potassium in electrolyte determination. From the cause analysis, it is probably that heparin and potassium generate heparin potassium, which affects the determination of potassium by ion selective electrode, resulting in low blood potassium. At the same time, for serum samples, due to the destruction of platelets in the process of blood coagulation, the potassium ion in platelets (its concentration is much higher than plasma potassium) releases human blood, making the serum higher than plasma potassium, The increase was positively correlated with the number of platelets.

Serum potassium heparin lithium can not accurately reflect the real level of potassium in the body due to the fragmentation of platelets in the real process of evacuating serum after blood coagulation, so it is initiated to use plasma potassium instead of serum potassium. According to the same common clinical experience, although there is the effect of platelet destruction, the determination of serum potassium is still due to the determination of plasma potassium. The tension is that serum potassium has no effect of heparin, and serum is widely accepted as a sample in the old biochemical examination and analysis in China. From the perspective of the experience of professional doctors, this conclusion is also created.

Heparin products represented by heparin lithium and heparin sodium have significant anticoagulant performance after blood collection. Whole blood cell count and blood cell examination are often used. Desheng biochemical is deeply engaged in the field of vascular preparations, and has more than 20 independently developed patented technologies. Ensure that the products obtained by customers are better than the average level of peers and enjoy high-quality after-sales technical service.