Ethylenediaminetetraacetic acid (EDTA) is a commonly used chelating agent, widely used in various fields, including medical examinations, chemical analysis, etc. And ethylenediaminetetraacetic acid tripotassium (EDTA K3) is the potassium salt form of ethylenediaminetetraacetic acid, which is used as an additive in EDTA tubes for blood anticoagulation in vacuum blood collection vessels. In addition to EDTA tripotassium, EDTA dipotassium and EDTA disodium may also be added to the EDTA tube.
The role of ethylenediaminetetraacetic acid tripotassium in blood collection:
Prevent blood clotting: Tripotassium ethylenediaminetetraacetate can chelate calcium ions in the blood, reducing the concentration of free calcium ions in the blood. When the concentration of calcium ions decreases, the difficulty of activating prothrombin increases, effectively preventing blood clotting.
Protecting blood components: In addition to preventing blood clotting, potassium ethylenediaminetetraacetate can also protect various components in the blood from damage. For example, it can protect the structure and function of blood cells such as red blood cells, white blood cells, and platelets, thereby ensuring the accuracy and reliability of blood samples. This is crucial for subsequent blood testing and analysis.
What tests can potassium ethylenediaminetetraacetate be used for
EDTA potassium anticoagulant tube, as one of the commonly used anticoagulant blood collection vessels in clinical testing, can provide accurate and reliable basis for various tests. Below, we will provide a detailed introduction to the application of EDTA potassium anticoagulant tubes.
1、 Blood cell analysis and blood routine testing
EDTA potassium anticoagulant tubes are commonly used tools for blood cell analysis and blood routine testing. In such testing, it is necessary to obtain a whole blood sample for counting and analyzing blood components such as red blood cells, white blood cells, platelets, etc. The presence of EDTA tripotassium is crucial for accurate measurement of blood cell counts, as it can provide accurate information on the number, morphology, and distribution of blood cells, providing strong support for clinical diagnosis and treatment.
2、 Platelet function testing
In addition to blood cell analysis and blood routine testing, EDTA potassium anticoagulant tubes are also widely used for platelet function testing. Platelets play an important role in hemostasis and thrombosis, and abnormal function may lead to bleeding or thrombotic diseases. EDTA potassium anticoagulant tubes can maintain the natural morphology and function of platelets, making the detection of platelet adhesion, aggregation, and release more accurate and reliable.
3、 Serum biochemical testing
EDTA potassium anticoagulant tubes can also be used for serum biochemical testing, such as the determination of liver function, kidney function, myocardial enzymes, amylase and other indicators. In these tests, serum isolation is required to remove cellular components and interfering substances from the blood. The anticoagulant effect of EDTA tripotassium can prevent blood coagulation and the formation of fibrin, which is beneficial for the separation and purification of serum. Meanwhile, it has a relatively small impact on enzyme activity and metabolites in the blood, ensuring the accuracy and reliability of biochemical indicators.
4、 Electrolyte detection
Electrolytes are essential substances for maintaining normal physiological functions in the human body, and their balance is crucial for human health. EDTA triple potassium anticoagulant tubes can be used for the detection of serum electrolytes, such as the determination of serum potassium, sodium, chloride, calcium, phosphorus and other indicators. In these tests, it is necessary to obtain serum samples without clots to ensure measurement accuracy. EDTA tripotassium can effectively prevent interference from blood coagulation and fibrinogen, providing clear serum samples for measurement with a power analyzer.
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