Functions and advantages of 4-(2-Hydroxyethyl)-1-Piperazineethanesulfonic Acid and Tris(Hydroxymethyl)Aminomethane in cosmetics

Now more and more women pay attention to skin care, and even more and more men begin to pay attention, because a good skin will give people a clean and comfortable impression. On the market, mild hydrated and non irritating cosmetics are more and more popular with the public. The advertising slogan of major brands of cosmetics is "add safely and non irritating", which makes the majority of consumers and manufacturers pay attention to the added ingredients of cosmetics, and HEPES and Tris become popular additives.

HEPES (7365-45-9) and tris (77-86-1) are the ingredients with EWG green certification, which are safe and mild. The certification level of tromethamine is 1-2, and that of HEPES is 1. This article will introduce the role of HEPES and Tris in cosmetics.

HEPES and Tris are important buffers widely used. Tris is weakly alkaline, PKA is 8.06 at 25 ℃, pH buffer range: 7.0-9.0, widely used in biochemistry, molecular biology, coatings and other fields.

HEPES, 4-hydroxyethyl piperazine ethanesulfonic acid, is a kind of zwitterionic buffer, belonging to good's buffer, with pH buffer range of 6.8-8.2. HEPES buffer is often used in the research of organelles and pH sensitive proteins and enzymes, as well as in biochemical diagnostic kits, DNA / RNA extraction kits and PCR diagnostic kits.

As a component of cosmetics, HEPES and Tris have different functions and advantages.

The most common function of Tris in cosmetics is to adjust pH value (pH value). It can also be used as a neutralizing agent to neutralize Thickener (carbomer), so as to reduce the sticky feeling, improve the respiratory efficiency of skin cells, and prevent pore blockage.

In addition, Tris can be used as an odor regulator in cosmetics containing amine salts to regulate the odor of amine produced by rubbing when applying cosmetics, so as to avoid the release of any residual or persistent odor.

HEPES has the advantages of safety to human body, non-toxic, good physiological compatibility and stable chemical performance. From the perspective of EWG certification level, HEPES is safer than Tris. HEPES can stabilize the pH range of skin care products for a long time, better maintain the activity of microbial fermentation products extract, and make the anti-aging effect of products last for a long time, so it is often used as a stabilizer and activator in cosmetics.

HEPES is also a common penetration enhancer, which can promote the transdermal absorption of various functional components in cosmetics. Compared with azone penetration enhancers, HEPES has the characteristics of short onset time, less dosage and high penetration rate. In addition, in some famous cosmetics such as L'Oreal and Lancome, HEPES is mainly used as a peeling agent to soften cutin and promote the metabolism of skin cells.

EWG certification has become an important standard for people to choose safe cosmetics. EWG safety level is 1-10, of which 0-2 is green safety level, 3-6 is yellow, representing medium hazard, 7-9 is red, representing high hazard. The EWG certification of HEPES and Tris belong to the green level, reaching the international standard, meeting the people's demand for "safe and natural" cosmetic ingredients.

Desheng has more than ten years of experience in the production and development of biological buffers, blood collection additives and in vitro diagnostic reagents, and insists on providing high-quality products for customers. HEPES and Tris are popular products of the company. Can also provide customers with neutralizing thickener carbomer.