The role of tris(hydroxymethyl)aminomethane TRIS in the treatment of hyperuricemia

Tris is also called tromethamine, cas77-86-1. Trihydroxymethyl aminomethane (Tris) is often used as biological buffer, TAE and tbe buffer (used for nucleic acid dissolution) are commonly used in biochemical experiments. What other applications does it have? Now let's take a look.

In the field of medicine, Tris is not only an important pharmaceutical intermediate, but also a drug itself. It is suitable for metabolic acidemia, respiratory acidemia and other diseases, especially in the treatment of hyperuricemia, with ideal effect.

Hyperuricemia can be divided into primary hyperuricemia and secondary hyperuricemia, mainly due to excessive source or (and) insufficient excretion of uric acid. Under normal circumstances, if the level of uric acid in men is higher than 420 μ mol / L and that in women is higher than 360 μ mol / L, it is hyperuricemia. According to social understanding, the high incidence age of hyperuricemia is middle-aged and elderly men and postmenopausal women, and there is a trend of younger in recent years.

At present, the prevention and treatment strategies of hyperuricemia mainly include reducing intake, inhibiting endogenous synthesis, and promoting renal excretion. Among them, promoting renal excretion is mainly achieved by alkalizing urine and inhibiting uric acid transporter. Inorganic metal cations such as Ca2 +, Mg2 +, NH4 + in urine can inhibit the dissolution and excretion of uric acid, while alkaline factors can promote the dissolution of uric acid. Therefore, trimethylolmethane and sodium bicarbonate are often used in this process. However, trimethylolmethane is better than sodium bicarbonate in promoting the dissolution and excretion of uric acid.

After taking sodium bicarbonate, the increased cationic Na + will further antagonize HCO3 alkalization of urine and blood, and promote the dissolution and excretion of uric acid. When sodium bicarbonate exceeds a certain dose, it will even reduce the solubility of uric acid. However, sodium bicarbonate can be produced endogenous. There is sodium bicarbonate in the human body, and there is a great fluctuation in the urine, so the concentration of sodium bicarbonate is not easy to control. If you take a small amount of sodium bicarbonate, the effect of excreting uric acid is not good. If you take more sodium bicarbonate, it may aggravate the deposition of uric acid in the urinary system, and the intake of sodium salt will also increase the cardiovascular and renal burden.

Tris is an organic amino base without inorganic cations, which can avoid or weaken the inhibition of inorganic cations. In addition, Tris is a foreign substance, so the body will not produce Tris. Therefore, the concentration of Tris in the body is better controlled than that of sodium bicarbonate in the course of medication The dissolution of uric acid promoted by trimethylaminomethane was better than that by sodium bicarbonate.

Desheng has been making deep research on biological buffers, and can provide high-quality raw materials such as Tris, bicine, HEPES, etc. Desheng adheres to the company's philosophy of "quality first, technology leading" to provide customers with high-quality products.