The quality control of clinical samples before analysis and testing is extremely important, but in actual work, inspectors often ignore the impact of specimen placement time on the accuracy of the test results, resulting in many specimens that cannot be sent for inspection soon after collection. The process of specimen transportation and the separate inspection of different batches caused a lot of time delay for some specimens. In addition, many hospitals did not indicate the collection time of the specimen on the specimen submission form, and the specific placement time of the specimen is not known. As an inspector, you must have a certain understanding of the impact of specimens placed for too long on the results of different items.
Impact on biochemical test results
1. Blood sugar: GLU of blood samples at room temperature degrades by about 5% per hour, mainly due to the glycolysis of glucose and the consumption and absorption of sugar by cells. After the blood is separated, glycolysis provides energy for red blood cells, bacteria decompose glucose, and leukocyte degrading enzymes. These factors will cause the blood glucose concentration to gradually decrease with the prolonged storage time.
2. Electrolytes: With the prolongation of the time of blood isolation, the ATP production barrier and the increase of cell membrane permeability lead to the transfer of ions inside and outside the cell. K+ and Na+ levels increase after 4 hours, and to a greater extent after 8 hours. Fluctuations.
3. Liver function indicators: 4 hours after the blood sample was placed, AST and ALP increased, while TBIL and ALT decreased. The main reason is that AST and other factors in red blood cells can be transferred to the outside of the cell to increase the enzyme activity and accelerate the lysis of red blood cells, while TBIL can be oxidized with the bilirubin, resulting in abnormal cytokine levels.
4. Kidney function indicators: blood Scr is not affected by the time of specimen placement, while blood BUN and β2-microglobulin are significantly reduced. It may be that the lipoprotein particle structure has changed or even cracked during the placement of lipoprotein cholesterol, so BUN The levels of β2-microglobulin and β2-microglobulin decreased as the time of blood isolation increased.
It turns out that timely delivery of specimens is so important for biochemical testing. Therefore, in order to control the quality of the test, it is necessary to complete the test of biochemical indicators within 4 hours of placing the blood specimen to ensure the accuracy of the results. Desheng produces blood collection tube additives. The old brand manufacturers, including blood anticoagulant, coagulant, serum separation gel and other products, can be applied to various biochemical testing projects. It is derived from the trust in product quality and professional services. It has accumulated a lot of long-term Repurchase customers, Desheng is your trusted choice!
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