What are the advantages of the chromogenic substrate MAOS compared with other chromogenic reagents

The full name of the chromogenic substrate MAOS is N-ethyl-N- (2-hydroxy-3-sulfopropyl)-3,5-dimethylaniline sodium salt monohydrate, CAS No. is 82692-97-5. As other new Trinder ’s reagents, it has high water solubility and sensitivity much higher than traditional chromogenic reagents commonly used in some laboratories, so it is widely used in clinical testing and biochemical reagent kits.

First, the biggest feature of MAOS is that the maximum absorption wavelength of its oxidized product is far more than that of ordinary chromogenic reagents. Even in the new Trinder ’s reagent, its product UV absorption wavelength is 630nm, which is quite high. The maximum absorption wavelength of products of many chromogenic reagents is in the visible light region. If testing human blood or other body fluids, due to the complex components in the sample to be tested, the sample itself contains a small amount of components that absorb wavelengths in the visible light region or absorb with chromogenic products. The wavelengths are close, which will make the detection result high. If you use something like MAOS, the maximum absorption wavelength of the product is in the ultraviolet region and it is relatively high, which will greatly reduce interference. Therefore, it is recommended to use MAOS as a chromogenic substrate for some biochemical testing items that require highly accurate values.

Secondly, the chromogenic reaction of MAOS chromogenic substrate has a wider adaptability to the pH of the reaction system, which greatly improves its adaptability. The reaction of some chromogenic reagents is often performed under acidic conditions, but the biochemical detection usually requires the participation of enzymes. We know that the catalytic effect of enzymes is relatively sensitive to the pH of the reaction environment, and it may not match the chromogenic reagent Inactivation will be greatly restricted in use, and MAOS reagents do not have this problem.

Another point is that the MAOS chromogenic reaction has a larger molar absorption intensity, so its sensitivity is relatively high. It should be noted that MAOS will fade when the detection time is too long, so the MAOS detection needs to be completed in time and cannot be interrupted. In addition, MAOS is also relatively safe. Unlike DAB and other biphenyl chromogenic reagents, although the price is relatively low, it has certain carcinogenicity or mutagenicity.

Desheng Technology has been committed to the development, production and sales of various chromogenic substrates, especially TOOS, MAOS, ADPS, etc. have a good reputation at home and abroad, and have good cooperation with many biochemical kit manufacturers Relationship, and jointly contribute to the field of domestic diagnostic reagents!