N,N-bis(hydroxyethyl)glycine, alias Bicine, CAS number is 150-25-4, Bicine is a biological buffer; biological buffer is recommended for low-temperature biochemical work. Used to prepare a stable substrate solution for serum guaninase determination. It is also a very versatile Buffer, used for enzyme reaction buffer, electrophoresis buffer, working concentration from 3-100mM.
Bicine is often used as a buffer solution for capillary electrophoresis.
N, N-Dihydroxyethylglycine Bicine is a zwitterionic buffer, belonging to Good’s buffer, with a pH buffer range of 7.6-9.0. The molecular structure of Bicine is similar to that of glycine. The molecule has a substituted amino group, a carboxyl group and two hydroxyl groups as coordinating groups, so it has the properties of an amino acid and aminoethanol at the same time, and can form a metal complex with a single anion (Bic-) , Is often used as a buffer solution for capillary electrophoresis.
Bicine is an effective inhibitor for the oxidative degradation of amines.
According to the patent CN104245089A description, Bicine is an effective inhibitor for the oxidative degradation of amines, and can effectively inhibit the oxidative degradation of the amines used or the amine-containing absorbents used.
Bicine is used as a chelating agent for soil remediation.
Bicine is an amino acid analogue that is easily soluble in water. It is an environmentally friendly substance. It contains two -OH and one -COOH in its molecule. It has good chelating properties and can chelate heavy metal ions such as Cu, Cd, and Pb, but Can not chelate calcium and magnesium ions. Therefore, Bicine is often used as a chelating agent to repair soil contaminated by heavy metals. Bicine has a good elution ability for heavy metals under neutral and acidic conditions, and can efficiently remove Cu, Cd, and Pb ions in contaminated soil. Bicine is an eluent of active components, which can not only wash and repair heavy metals. It pollutes the soil, and can avoid the loss of plant nutrient elements calcium and magnesium in the soil, is safe and environmentally friendly, and will not cause secondary pollution to the environment.
Bicine is also a widely used in vitro diagnostic reagent raw material, suitable for biochemistry and medicine. In the field of in vitro diagnostics, it is an important raw material for antibody detection reagents and nucleic acid detection reagents.
