Carbomer produced by Hubei New Desheng is white loose powder with strong hygroscopicity. Therefore, it must be stored in a plastic bag at a dry place . When we use carbomer, it is usually made into gel and added into raw materials of daily chemicals or medicals.
What Influence the Characteristic of Carbomer Gel?
1. Carbomer gel properties are influenced by pH value
With a large number of free carboxyl groups, the pKa value of carbomer polymers are usually small. If the PH of the medium is less than 4, the carboxyl groups are rarely separated, and if the PH is greater than 4, the carboxyl groups begin to separate, the polymer dissolves, and the viscosity increases.When PH reached 8, it is basically completely separated and the viscosity is the largest.
The PH value of the medium also affects the adhesion of carbomer gels. When the pH value is lower than pKa, the binding ability of the gel is strong, and the adhesion will increase. At the same time, the ionic strength of the medium can change the sensitivity of the carbomer gel to pH value. When the ionic strength is high, the carbomer releases protons and decrease its pKa value, so it can be dissolved at a lower PH value.
2. Carbomer gel properties are influenced by ionic strength
In some drugs, the effect of the drug on the PH and ionic strength of the medium around the gel cannot be ignored. The acidity of the drug also affects the properties of the gel, so the effect of acidic drugs is more pronounced.
3. Carbomer gel properties are influenced by other excipients
The simultaneous use of polyvinylpyrrolidine and polyoxyethylene as auxiliary agents with carbomer gels can reduce the mucoadhesion of carbomer gels. The degree of reduction is related to the concentration and molecular weight of coexisting excipients. The high concentration over 5% of excipients can greatly reduce the adhesion of carbomer gel, and if the concentration is reduced to 0.5%, the effect is small. Generally, the PH value of the medium does not change this property of polyvinylpyrrole and polyoxyethylene. Magnesium stearate is hydrophobic,which also reduces the adhesion of carbomer gels.
Above is the detailed introduction of Hubei New Desheng Material Technology Co., Ltd. on the factors that affect the properties of carbomer gel. Hubei New Desheng Material Technology Co., Ltd. is a manufacturer specializing in the production of raw materials for biochemical testing and detection reagents, including carbomer 940 and 980 with chemical level. We provide guaranteed quality,welcome your consultation and understanding.
