What is the difference between the blood anticoagulant heparin calcium and heparin sodium?

There are many types of heparin salt blood anticoagulants. Heparin sodium is the most commonly used, but heparin calcium is used in some places. Is there any difference between heparin calcium and heparin sodium in blood anticoagulation?

Heparin sodium is used for anticoagulant drugs and other non-drug reagents such as blood collection tubes or cosmetics. The potency, purity and impurity content of heparin sodium for different purposes are different; while heparin calcium is mainly used for For drugs, the requirements are relatively high.

Heparin sodium and heparin calcium are both used as blood anticoagulants, and the principle of action is similar. Both use heparin to anticoagulate. Unfractionated heparin and low molecular weight heparin can be combined with antithrombin iii to increase the affinity of antithrombin iii and coagulation factors, and play the role of anticoagulation factors.

Low-molecular-weight heparin has two forms, sodium salt and calcium salt, but the clinical efficacy is not much different. Heparin calcium is slightly stronger than heparin sodium in anticoagulant factor 2a, and the anticoagulant effect is relatively weak, but overall there is no significant difference in clinical efficacy.

Heparin sodium is easy to cause subcutaneous hemorrhage when injected subcutaneously, and local stimulation of heparin calcium is slightly lighter than heparin sodium when injected subcutaneously, which can effectively avoid this adverse reaction.

In the beginning, there was only heparin sodium, but later it was discovered that its bioavailability was relatively low, and there would be local adverse reactions. For example, when choosing subcutaneous injections around the umbilical area, ecchymosis may appear. In severe cases, the bioavailability of heparin calcium is relatively high, and the absorption is relatively fast. Local adverse reactions, especially subcutaneous ecchymosis, are relatively rare.

Heparin sodium is generally used for needle sealing for infusion patients, and its effect is quite good. However, when patients choose subcutaneous injection, it is better to choose heparin calcium, so the adverse reactions will be smaller.

Regarding how to choose heparin sodium and heparin calcium, the specific use should be under the guidance of a specialist, and an individualized medication plan should be made according to your own situation. What needs to be reminded is that Desheng brand heparin sodium is not a medicine and cannot be used as a medicine. It can only be used as an anticoagulant for blood testing in blood collection tubes.