What details should be paid attention to during the transportation of pyruvate kinase 9001-59-6

As a key enzyme in cellular respiration and glucose metabolism pathways, the stability and activity of pyruvate kinase directly affect physiological processes such as cellular energy metabolism and tumor cell proliferation. In scientific research and clinical applications, the transportation of pyruvate kinase must strictly follow the special requirements of biological agents to ensure its activity is not affected by environmental factors. This article will analyze in detail the key details of pyruvate kinase transportation from four dimensions: transportation environment control, packaging standards, operational safety, and regulatory compliance.

1, Transportation environment control: dual protection of temperature and lighting

The activity of pyruvate kinase is highly sensitive to temperature, and an appropriate temperature control scheme should be selected during transportation based on product characteristics to avoid enzyme denaturation caused by extreme temperatures. Pyruvate kinase can be transported in ice bags. The packaging temperature is maintained at 0-4 ℃ through the double sealing of ice bags and foam boxes to ensure that the enzyme activity will not be affected in the high temperature transportation environment.

pyruvate kinase

Light exposure can also cause irreversible damage to pyruvate kinase. During transportation, the product needs to be completely protected from light and wrapped in black light blocking bags or aluminum foil bags to avoid direct exposure to ultraviolet or visible light. In addition, the transport box should be made of opaque materials to further reduce the risk of light exposure.

2, Packaging specification: Dual protection of sealing and labeling

Packaging is the core link in the transportation of pyruvate kinase. According to the product characteristics of pyruvate kinase, the transportation packaging needs to be wrapped with high-strength tape in multiple layers to ensure sealing. At the same time, the packaging box should be labeled with warning signs such as "biological agents" and "fragile items", and key information such as product name, CAS number, storage conditions, and expiration date should be indicated. In addition, the transportation of pyruvate kinase requires strict compliance with relevant management regulations and the selection of logistics companies with relevant qualifications. When transporting LCL, attention should be paid to acid-base isolation requirements to avoid mixing with other dangerous goods.

3, Operational safety: dual mechanism of protection and emergency response

Operators need to receive professional training and be familiar with the biosafety characteristics of pyruvate kinase. During transportation, it is necessary to wear protective equipment throughout the entire process, including protective clothing, goggles, chemical gloves, and long rubber shoes. If a leak occurs, the emergency plan should be activated immediately: small-scale leaks can be absorbed with absorbent cotton, while large-scale leaks need to be covered with sand and transferred to a dedicated container.

Transportation vehicles must be equipped with fire-fighting equipment and emergency response devices for leaks, such as fire extinguishers, adsorbents, and neutralizing agents. Transport vehicles need to be regularly checked for sealing to avoid packaging damage caused by vibration or bumps. For cross-border transportation, it is necessary to understand the import regulations of the destination country in advance to ensure complete documentation and compliance with quarantine requirements.

4, Regulatory Compliance: Dual Verification of Documents and Processes

The transportation of pyruvate kinase must strictly comply with domestic and foreign regulations. Domestic transportation requires product manuals, safety data sheets (MSDS), and transportation identification reports. Cross border transportation requires additional preparation of proof of origin, health certificate, and import/export license, and declaration in accordance with relevant regulations.

Temperature, humidity, and lighting data must be recorded throughout the transportation process to ensure traceability. If cold chain transportation is used, temperature control equipment with real-time monitoring function should be used, and data should be uploaded in real time through a cloud platform. After arriving at the destination, activity testing is required to ensure that enzyme activity meets the standards.

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