Product Details
Place of Origin: Ezhou city,Hubei province,china
Brand Name: Desheng
Certification: ISO 9001
Model Number: CAS 9003-01-4,white powder,20kg/paper package
Payment & Shipping Terms
Minimum Order Quantity: 20kg
Price: Negociated
Packaging Details: 20kg/paper package
Delivery Time: 4-10 days
Payment Terms: L/C, T/T
Supply Ability: 1000kg three days
Color: |
White |
Appearance: |
Powder |
CAS: |
9003-01-4 |
Package: |
20kg/paper Package |
Viscosity 1: |
0.2% Aqueous Solution:13000~30000mPa.s |
Viscosity 2: |
0.5% Aqueous Solution:40000~60000mPa.s |
Carboxylic Acid Content , %: |
56.0~68.0 |
Color: |
White |
Appearance: |
Powder |
CAS: |
9003-01-4 |
Package: |
20kg/paper Package |
Viscosity 1: |
0.2% Aqueous Solution:13000~30000mPa.s |
Viscosity 2: |
0.5% Aqueous Solution:40000~60000mPa.s |
Carboxylic Acid Content , %: |
56.0~68.0 |
Carbomer, a white loose powder, requires special attention to keeping it dry during storage due to its strong hygroscopicity. When we use this powder to make gel and use it for daily chemicals or medical materials, the performance of gel will be affected by many factors. The following are several main influencing factors:
carbomer
The influence of pH value
Carbomer polymers contain a large amount of free carboxyl groups, and their pKa values are relatively low. When the pH value of the medium is less than 4, these carboxyl groups hardly dissociate, and the viscosity of gel remains low. However, with the increase of pH value, especially when the pH value is greater than 4, the carboxylic acid begins to dissociate, and the polymer swells, leading to a significant increase in the viscosity of gel. When the pH value reaches 8, the dissociation of carboxylic acid is almost completed, and the viscosity of gel reaches the maximum value.
When carbomer is used as a drug carrier, the dissolution of the drug may lead to an increase in the pH value of the medium. This further enhances the dissociation of carbomer, thickens the gel layer, and reduces the drug release rate, thus realizing the control of drug release. In addition, the pH value of the medium will also affect the adhesion of the Carbomer gel, especially when the pH value is lower than its pKa, the gel shows stronger binding ability and adhesion.
It is worth noting that the ionic strength of the medium will also change the sensitivity of the Carbomer gel to pH. At high ion strength, carbomer is more likely to release protons, leading to a decrease in its pKa value, thus allowing for dissociation and dissolution at lower pH values.
The influence of ion strength
In some drug delivery systems, the influence of drugs on the pH value and ionic strength of the surrounding medium of the gel is significant. Especially acidic drugs, such as 2,5-dihydroxybenzoic acid, can significantly affect the properties of gel. Such drugs can increase the adhesion of gel and make the gel layer formed by them thicker than other drugs (such as salicylic acid).
The impact of other auxiliary materials
In the formulation of Carbomer gel, the use of other excipients may also affect the performance of gel. For example, the use of polyvinylpyrrolidone and polyoxyethylene as excipients may reduce the mucosal adhesion of Carbomer gel. The degree of reduction is related to the concentration and molecular weight of coexisting excipients. High concentration excipients (more than 5%) will significantly reduce the adhesion of gel. However, when the concentration of excipients decreases to 0.5%, its impact is relatively small.
Product packaging
In addition, magnesium stearate will also reduce the adhesion of Carbomer gel due to its hydrophobicity. The influence of these excipients usually does not change when the pH value of the medium is changed, indicating that their influence on gel performance is independent of the pH value.
In conclusion, understanding and controlling these key factors is crucial to ensure the performance of Carbomer gel.Desheng specializes in producing carbomer, with a large quantity in stock. Welcome to purchase!