CAS No 9003-01-4 Carbomer In Pharmacy Strong Hygroscopicity

CAS 9003-01-4 color white The basics of carbomer and its application in pharmacy

Carbomer is a high-molecular polymer crosslinked with acrylic acid and allyl sucrose or propenyl pentaerythritol. It was first produced by G00drich in the United States under the trade name of Carbop (Carbop01). The 2005 edition of the Chinese Pharmacopoeia has been included. This product is a loose white powder, acidic, hygroscopic and special slightly odor, soluble in water, ethanol, and glycerin. The molecule contains 56% to 58% carboxyl groups, so it is weakly acidic. When the carbomer is dispersed in water, due to the repulsion between the negative charges generated by the ionization of the carboxyl group, the curled polymer stretches out and expands in volume. The pH of the 0.5% water dispersion is 2.7 to 3.5. The 1% water dispersion can be neutralized with alkaline substances to form a gel. The concentration of commonly used water dispersion is 0.1% to 3.0%. The viscosity of Carbomer 980 gel is positively related to the concentration. The higher the concentration, the higher the viscosity of the gel. Carbomer 980 at different concentrations is different from the previous initial pH. The higher the concentration, the lower the initial pH.

Carbomer Gel

Carbomer advantages: good gel, viscosity, thickening, emulsifying, suspending and film-forming properties, stable and safe chemical properties, no irritation and allergic reactions, and good at low pressure The compressibility and compatibility with most other auxiliary materials are good. It can increase the bioavailability and show good correlation between in vivo and in vitro. It can be made into pharmaceutical preparations with zero-order release rate. It can form a soluble gel-type internal salt with basic drugs to release the drugs slowly. Salt electrolytes can reduce the viscosity of the carbomer gel. Alkaline earth metal ions and polymers can be combined with them to form insoluble salts. Strong acids can also make the carbomer lose its viscosity, which must be avoided during compatibility.

Disadvantages:
(1) It has strong hygroscopicity and is easy to agglomerate, so it should be kept away from moisture.

(2) Carbopol dry powder and high-concentration glue are irritating to the eyes, nose and throat. After contact, they can be washed with physiological sodium chloride solution.

(3) Non-solid state has no antibacterial effect, but does not support bacterial growth, so preservatives should be added.

Application in pharmacy The main functions of Carbopol: thickening, suspending, emulsification, etc., in pharmacy, it can be used as a gelling agent, adhesive, coating material, rheology modifier (humidifier, lubricant) , Suspending agent, stabilizer), etc., are widely used, especially in the new drug delivery-1-system has greater application prospects. 2.1 Application in topical gels Gels can not only be used as a dosage form for topical skin absorption, but also expanded in other ways of administration. The gel matrix made of carbomer has the characteristics of a water-soluble matrix, which releases quickly, is non-greasy, easy to spread, non-irritating to skin and mucous membranes, can be mixed with aqueous solutions and can absorb tissue exudate , Is conducive to the elimination of secretions. Compared with petroleum jelly base and cream base, it has the advantages of simple operation, stable quality, and no need for open flame heating.

Hubei New Desheng Material Technology Co., Ltd. now professionally provides Carbomer 980, interested parties can contact

Website: http://www.whdsbio.com

Address: C8-2, Optics Valley United Science and Technology City, Ezhou City, Hubei Province