9045-22-1 High Potency Lithium Heparin Salt Anticoagulant For Blood Testing Tube Vacuum

CAS 9045-22-1 High Potency Lithium Heparin Salt Anticoagulant For Blood Testing Tube Vacuum

Heparin is a blood anticoagulant commonly used in vacuum blood collection tubes. Heparin anticoagulants are usually its sodium, potassium, lithium, and ammonium salts, such as sodium heparin and lithium heparin, among which lithium heparin is the best.

The finished product of lithium heparin is white to off-white powder, odorless, easily soluble in water, and easy to absorb moisture. According to the research, there is no statistically significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, and CRP in lithium heparin anticoagulated plasma and serum (P>0.05). There was a statistically significant difference in the detection results of HBD, LDH and TBA in lithium heparin anticoagulated plasma and serum (P<0.05). Therefore, in addition to HBD, LDH, and TBA, the correlation between lithium heparin anticoagulated plasma and serum is better. Therefore, it is more feasible to use lithium heparin anticoagulated plasma instead of serum in life testing, and it can be used as an important testing method.

Lithium heparin

Product name	Lithium Heparin
Formula	(C27H26N3S7Li9)nR	HS Code	30019010.00
Molecular weight	15000-19000	Cas no	9045-22-1
Structure		EINECS no	232-681-7
		Potency	162IU/mg
		pH Value	7.13
Appearance	Powder	Color	White
Odor	odorless	Solubility	≥40%
Specific optical rotation	+45.10°	Color of solution	Colorless
Nitrogen	2.4%	Lithium	3.9%
Sodium	0.17%	Sulphur	13.6%
Chloride	≤0.5%	Heavy metal	≤30ppm
Calcium	None	Loss on drying	≤5.0%
Packing way	O53	Packing size	10g/bottle
Danger classification	R21-25-36/37/38	Safety classification	S22-24/25-36-26
Application	Blood collection tube additive

【Scope of application】

1. This product is suitable for the collection and anticoagulation of blood specimens for clinical biochemical examinations and emergency biochemical examinations, as well as blood specimen collection and anticoagulation for some hemorheology items.

2. When determining the content of ions in the blood in clinical tests, it is recommended to use lithium heparin as an anticoagulant, because it is the least likely to interfere with the determination of other ions.

3. This product is not a medicine and cannot be used as an injection. It is forbidden to directly inject into humans and animals.

【Precautions】

1. After the heparin salt test tube blood collection is completed, it must be inverted and mixed 5-8 times as soon as possible

2. Heparin anticoagulation is not irreversible anticoagulation, so the test should be completed within 6 hours after blood collection from the lithium heparin anticoagulation test tube

3. Heparin may be involved in the metabolism of cell enzymes and ions. The added dosage of heparin should ensure adequate anticoagulation in all and part of the specimen, especially sensitive indicators such as AST, ALT, TBIL, DBIL, and GGT.

4. Lithium heparin can be used with separation gel at the same time, anticoagulation effect, tube wall siliconization, centrifugal conditions, separation gel quality, etc. will affect the blood separation effect. It is recommended to be used in conjunction with the blood separation gel produced by our company.

5. Sterilization suggestion: use gamma ray irradiation with a dose of 8-25kGy.

The titer of Lithium Heparin of Desheng Company is ≥150IU/mg, and the titer of anhydrous ≥160IU/mg. Other indicators are controlled according to the standard of heparin sodium raw material. Store in a cool and dry place, sealed and protected from light and not damp. The aqueous solution of this product can be sealed and stored at 0-4°C in a sterile state, and the maximum shelf life should not exceed 7 days. The aqueous solution is ready to use.

[product name] lithium heparin

[Molecular weight] 8000 ~ 15000

[Properties] white or milky white amorphous powder, easy to deliquesce.

[validity] The dry state is not less than 150.0iu/mg.

[pH] 1% (w / v; 1g / 100ml) pure aqueous solution ph value between 6.0 ~ 8.0.

[Solubility] 5% (w/v; 5g/100ml) solution was clarified.

[Packing specifications] 10g / bottle, 50g / bottle

As for the anticoagulant of lithium heparin, some people may confuse it, and it is easy to recognize it as sodium heparin, but they actually belong to two substances. The binding ions of heparin sodium and lithium heparin are different. Although both heparin lithium and heparin sodium have anticoagulant effects, and are also a combined form of heparin, the effective ion binding is different, so the appearance The above looks like the same, but lithium heparin and sodium heparin are essentially different in texture, and their dissociation degree is also different.

Lithium heparin is white powder in appearance, odorless, easily soluble in water, and easy to absorb moisture. Its CAS number is 9045-22-1. As a commonly used blood anticoagulant, lithium heparin is very suitable for clinical biochemistry and acute biochemical examinations. At present, most of the current clinical biochemical index tests come from the traditional serological examination of venous serum. Blood coagulation is slow. The main reason for using lithium heparin as an anticoagulant is to inhibit the adhesion and aggregation of platelets. Strengthen the inactivation of thrombin, and also strengthen the effect of antithrombin III. Compared with heparin sodium, lithium heparin has stronger anticoagulant effect and faster plasma centrifugation.

Lithium heparin is used as a very good anticoagulant in clinical tests to determine the ion content in the blood because lithium heparin does not easily interfere with the determination of other ions. Among the commonly used heparins, lithium heparin is more suitable for this measurement experiment than other heparins. In addition, lithium heparin basically does not contain excess ions. Secondly, compared with the anticoagulant effect of heparin sodium, heparin lithium is faster.

In addition to being used in anticoagulation tubes, lithium heparin can also be used in other blood collection tubes. In addition, lithium heparin can be used with sodium fluoride and serum separation gel. When lithium heparin is matched with sodium fluoride, it can be used in blood glucose tubes.

Heparin can also participate in the metabolism of cell enzymes and ions, so the amount of heparin used may affect the test results. According to related reports, there is a significant gap between the results of CK-MB, LDH, GLU and other results of lithium heparin anticoagulated plasma and serum. The blood K, GLU, LDH, etc. measured by lithium heparin anticoagulated plasma are closer to the true concentration in the patient's body and have more reference value.