No Impurity Clot Activator Blood Collection Tube Additives Blood Coagulant

In medical practice, collecting blood samples is one of the important steps for diagnosing and monitoring the health status of patients. To ensure the quality and stability of blood samples, the use of coagulants in blood collection tubes has become indispensable. How is it handled during the blood sample process? Let's take a look together below.

The basic mechanism of action of blood collection vessel coagulant

Blood collection coagulants mainly promote blood coagulation through physical and chemical means. The physical coagulation effect is reflected in providing a surface for platelet aggregation, allowing platelets to quickly aggregate together. Chemical coagulation is achieved by activating prothrombin, promoting the release of thrombin, and triggering a series of coagulation reactions leading to blood clotting. These two mechanisms work together to enable blood collection vessel coagulants to significantly accelerate the process of blood clotting.

blood coagulants

The specific impact of blood collection coagulant on blood sample processing

1. Accelerating blood coagulation: The main purpose of blood collection vessel coagulant is to accelerate blood coagulation as much as possible without affecting blood components. By stimulating coagulation factors in plasma and platelets, coagulants can promote the formation of thrombin and fibrin clots, accelerating the contraction of blood clots. This rapid coagulation process plays an important role in obtaining serum samples in a timely manner, avoiding the occurrence of red blood cell rupture and hemolysis.

2. Maintain sample integrity: During blood clotting, coagulants help maintain the integrity of the blood sample. By using serum separation gel in combination, it can promote timely separation of serum, avoid mutual interference and cross contamination between blood components, help maintain the original state of various biomarkers and metabolites in the sample, and provide accurate data for subsequent experimental analysis.

3. Improving sample stability: Blood collection vessel coagulants can also enhance the stability of blood samples. By accelerating blood clotting, it helps to reduce changes in the sample during collection, transportation, and storage, and stable samples can reduce errors in experimental results.

Types of coagulants

1. Suspended liquid coagulant: The main components are thrombin, alcohol, silica powder, emulsifier, surfactant, etc. This coagulant exists in the form of a suspension, and its advantage lies in its ease of use and mixing. Adding an appropriate amount of suspended liquid coagulant to the blood collection tube and shaking it thoroughly can stimulate coagulation factors in plasma and platelets, promoting the formation of thrombin and fibrin clots.

2. Coagulation promoting powder: The coagulation promoting powder appears as a white powder, which has a strong coagulation promoting effect and can quickly stimulate the blood coagulation system, achieving rapid coagulation. Its powder can be mixed with water or alcohol to form a suspension and sprayed onto the inner wall of the blood collection tube. The main method used by most people nowadays is to prepare alcohol solvents, and it is generally not recommended to add dry powder.

The impact of improper use of coagulants

Proper use of coagulants can ensure the acquisition of high-quality blood samples, but incorrect use or handling may lead to the following issues:

1. Insufficient blood coagulation: If the coagulant is not fully mixed into the blood or the blood sample is not mixed in a timely manner after collection, it can lead to insufficient blood coagulation, affecting the accuracy of subsequent experiments.

2. Premature blood coagulation: Excessive use of coagulants may lead to premature blood coagulation, affecting the progress of subsequent experiments.

3. Distortion of experimental results: Incorrect use of coagulants may cause changes in the biochemical characteristics of blood samples, thereby affecting the experimental results. When using blood collection vessel coagulants to process samples, the operating conditions should be strictly controlled, including collection time, collection volume, sample storage temperature and time, etc. The control of these operating conditions helps to ensure the quality and stability of the samples and reduce experimental errors.

Product packaging

As a supplier of blood collection tube additives, Desheng can provide two different types and specifications of coagulants. Customers can customize them according to experimental requirements, and the product performance meets the standard, with the function of quickly promoting coagulation, which is highly welcomed by the market. At present, there is stock available for sale. If you are interested, please click on the website to inquire about details and make a purchase!