CAS 9045-22-1 Blood Collection Tube Additives Lithium Heparin White Crystal Powder

CAS 9045-22-1 Blood Collection Tube Additives Lithium Heparin White Crystal Powder

Lithium heparin

Product name	Lithium Heparin
Formula	(C27H26N3S7Li9)nR	HS Code	30019010.00
Molecular weight	15000-19000	Cas no	9045-22-1
Structure		EINECS no	232-681-7
		Potency	162IU/mg
		pH Value	7.13
Appearance	Powder	Color	White
Odor	odorless	Solubility	≥40%
Specific optical rotation	+45.10°	Color of solution	Colorless
Nitrogen	2.4%	Lithium	3.9%
Sodium	0.17%	Sulphur	13.6%
Chloride	≤0.5%	Heavy metal	≤30ppm
Calcium	None	Loss on drying	≤5.0%
Packing way	O53	Packing size	10g/bottle
Danger classification	R21-25-36/37/38	Safety classification	S22-24/25-36-26
Application	Blood collection tube additive

Heparin is a mucopolysaccharide containing sulfuric acid groups extracted from the intestinal mucosa of animals. It is a biologically active substance with a strong negative charge. Heparin has the effect of activating antithrombin III and inactivating serine protease in the blood, thereby preventing the formation of thrombin and preventing platelet aggregation and other anticoagulant effects. So how do we solve the following problems when we use it?

1. What is the difference between heparin sodium and lithium heparin as a blood collection tube?
Answer: The binding ions are different: Although both lithium heparin and sodium heparin are anticoagulated blood and are also a combined form of heparin, the effective ion binding is different, which also makes the appearance look the same Lithium heparin and sodium heparin are essentially different in texture, and their dissociation degree is also different. It can be said that heparin lithium is replaced from heparin sodium.
The dosage added to the blood collection tube is different: the actual use of heparin lithium and heparin sodium is still in the vacuum blood collection tube, while the dosage range of heparin lithium in the industry standard is 9.4IU~28IU unit/ml, and heparin sodium is per ml of blood. 12IU~30IU. The amount of lithium heparin and sodium heparin in one milliliter of blood in a venous vacuum blood collection tube is 15IU-20IU.
2. What grade is required for lithium heparin used in blood collection tubes?
Answer: The lithium heparin in the blood collection tube requires biochemical grade heparin lithium.
3. As an additive for common blood routine tubes, what is the recommended dosage of lithium heparin?
Answer: The general recommended dosage is 15-25IU per ml of blood, and the recommended dosage is 20IU/ml. The specific usage can be carried out according to the actual situation.
4. Why do some lithium heparin tubes show tiny coagulation fragments after blood sampling?
Answer: This is because the local anticoagulant concentration in the lithium heparin anticoagulant tube is too high, which causes part of the blood to enter the blood collection tube and cannot be fully mixed with the lithium heparin, which results in some small clots. This may be caused by the failure to invert and mix the test tube in time after blood sampling.
5. In addition to being used as an additive for green headgear, can lithium heparin be used as an additive for other tubes?
Answer: Yes. It can be used in conjunction with sodium fluoride and separating glue. When lithium heparin is used in combination with sodium fluoride, it can be used in blood glucose tubes, adding about 20IU per milliliter of blood. When lithium heparin is used in combination with separation gel, the dosage of lithium heparin remains unchanged, and 0.8-1.2 grams of separation gel can be added to each tube.
6. What are the storage conditions for lithium heparin?
Answer: This product can be sealed and stored in a cool and dry place, protected from light and protected from moisture. The aqueous solution of this product can be sealed and stored at 0-4°C in a sterile state, and the maximum shelf life should not exceed 7 days. It is recommended that the aqueous solution of this product be used immediately after preparation, and do not store it in a solution state for a long time. It is forbidden to use heparin lithium when there are foreign matter, abnormal smell, color and effective shelf life.

Heparin is a blood anticoagulant commonly used in vacuum blood collection tubes. Heparin anticoagulants are usually its sodium, potassium, lithium, and ammonium salts, such as sodium heparin and lithium heparin, among which lithium heparin is the best.

The finished product of lithium heparin is white to off-white powder, odorless, easily soluble in water, and easy to absorb moisture. According to the research, there is no statistically significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, and CRP in lithium heparin anticoagulated plasma and serum (P>0.05). There was a statistically significant difference in the detection results of HBD, LDH and TBA in lithium heparin anticoagulated plasma and serum (P<0.05). Therefore, in addition to HBD, LDH, and TBA, the correlation between lithium heparin anticoagulated plasma and serum is better. Therefore, it is more feasible to use lithium heparin anticoagulated plasma instead of serum in life testing, and it can be used as an important testing method.

【Scope of application】

1. This product is suitable for the collection and anticoagulation of blood specimens for clinical biochemical examinations and emergency biochemical examinations, as well as blood specimen collection and anticoagulation for some hemorheology items.

2. When determining the content of ions in the blood in clinical tests, it is recommended to use lithium heparin as an anticoagulant, because it is the least likely to interfere with the determination of other ions.

3. This product is not a medicine and cannot be used as an injection. It is forbidden to directly inject into humans and animals.

Lithium Heparin

【Precautions】

1. After the heparin salt test tube blood collection is completed, it must be inverted and mixed 5-8 times as soon as possible

2. Heparin anticoagulation is not irreversible anticoagulation, so the test should be completed within 6 hours after blood collection from the lithium heparin anticoagulation test tube

3. Heparin may be involved in the metabolism of cell enzymes and ions. The added dosage of heparin should ensure adequate anticoagulation in all and part of the specimen, especially sensitive indicators such as AST, ALT, TBIL, DBIL, and GGT.

4. Lithium heparin can be used with separation gel at the same time, anticoagulation effect, tube wall siliconization, centrifugal conditions, separation gel quality, etc. will affect the blood separation effect. It is recommended to be used in conjunction with the blood separation gel produced by our company.

5. Sterilization suggestion: use gamma ray irradiation with a dose of 8-25kGy.

The titer of Lithium Heparin of Desheng Company is ≥150IU/mg, and the titer of anhydrous ≥160IU/mg. Other indicators are controlled according to the standard of heparin sodium raw material. Store in a cool and dry place, sealed and protected from light and not damp. The aqueous solution of this product can be sealed and stored at 0-4°C in a sterile state, and the maximum shelf life should not exceed 7 days. The aqueous solution is ready to use.