CAS 9041-08-1 Blood Collection Tube Additives Sodium Heparin For Blood Testing

CAS 9041-08-1 Sodium Heparin for blood collection tubes Vacuum Additives Blood Testing

CAS9045-22-1 High Potency Lithium Heparin Salt Anticoagulant for Blood Testing

Heparin is a blood anticoagulant commonly used in vacuum blood collection tubes. Heparin anticoagulants are usually its sodium, potassium, lithium, and ammonium salts, such as sodium heparin and lithium heparin, among which lithium heparin is the best.

The finished product of lithium heparin is white to off-white powder, odorless, easily soluble in water, and easy to absorb moisture. According to the research, there is no statistically significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, and CRP in lithium heparin anticoagulated plasma and serum (P>0.05). There was a statistically significant difference in the detection results of HBD, LDH and TBA in lithium heparin anticoagulated plasma and serum (P<0.05). Therefore, in addition to HBD, LDH, and TBA, the correlation between lithium heparin anticoagulated plasma and serum is better. Therefore, it is more feasible to use lithium heparin anticoagulated plasma instead of serum in life testing, and it can be used as an important testing method.

【Scope of application】

1. This product is suitable for the collection and anticoagulation of blood specimens for clinical biochemical examinations and emergency biochemical examinations, as well as blood specimen collection and anticoagulation for some hemorheology items.

2. When determining the content of ions in the blood in clinical tests, it is recommended to use lithium heparin as an anticoagulant, because it is the least likely to interfere with the determination of other ions.

3. This product is not a medicine and cannot be used as an injection. It is forbidden to directly inject into humans and animals.

Anticoagulant Mechanism Of Heparin Sodium And Its Application

There are many kinds of blood anticoagulants, among which heparin sodium and heparin lithium are commonly used. Heparin sodium is a kind of acid mucopolysaccharide natural anticoagulant containing sulfate group. They are placed in the blood collecting vessels with different color caps, among which the green cap is heparin tube. Heparin sodium is commonly used in China, and its main function is blood anticoagulation, and the use of calcium ion The combination prevents the formation of thrombin and the coagulation of blood.

Heparin sodium can be used for the prevention and treatment of thromboembolic diseases, such as myocardial infarction, pulmonary embolism, cerebral vascular embolism, peripheral venous thrombosis, etc. it can avoid the formation and expansion of thrombosis, and can also be used for the early stage of DIC, and other anticoagulation in vivo and in vitro. Early application can avoid the depletion of fibrinogen and coagulation factors, and can also replace citrate in blood transfusion or as an extracorporeal anticoagulant during cardiopulmonary bypass.

Heparin sodium can delay or prevent blood coagulation both in vivo and in vitro. The mechanism of its effect is very complex, which affects many links in the coagulation process. The results are as follows

(1) to inhibit the composition and effect of coagulation activating enzyme, so as to prevent prothrombin from turning into thrombin;

(2) at higher concentration, it can inhibit thrombin and other coagulation factors, and prevent fibrinogen from transforming into fibrin;

③ It can prevent platelet aggregation and destruction. In addition, the anticoagulant effect of heparin sodium is still related to the sulfate radical with negative charge in its molecule. Alkaline substances with positive charge such as protamine or toluidine blue can neutralize its negative charge, so it can inhibit its anticoagulant effect.

Heparin Sodium is the sodium salt form of heparin. As a glycosaminoglycan anticoagulant, heparin sodium binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin. (NCI)

There are many kinds of blood anticoagulants, among which heparin sodium and heparin lithium are commonly used. Heparin sodium is a kind of acid mucopolysaccharide natural anticoagulant containing sulfate group. They are placed in the blood collecting vessels with different color caps, among which the green cap is heparin tube. Heparin sodium is commonly used in China, and its main function is blood anticoagulation, and the use of calcium ion The combination prevents the formation of thrombin and the coagulation of blood.

Heparin sodium can be used for the prevention and treatment of thromboembolic diseases, such as myocardial infarction, pulmonary embolism, cerebral vascular embolism, peripheral venous thrombosis, etc. it can avoid the formation and expansion of thrombosis, and can also be used for the early stage of DIC, and other anticoagulation in vivo and in vitro. Early application can avoid the depletion of fibrinogen and coagulation factors, and can also replace citrate in blood transfusion or as an extracorporeal anticoagulant during cardiopulmonary bypass.

Product name	Lithium Heparin
Formula	(C27H26N3S7Li9)nR	HS Code	30019010.00
Molecular weight	15000-19000	Cas no	9045-22-1
Structure		EINECS no	232-681-7
		Potency	162IU/mg
		pH Value	7.13
Appearance	Powder	Color	White
Odor	odorless	Solubility	≥40%
Specific optical rotation	+45.10°	Color of solution	Colorless
Nitrogen	2.4%	Lithium	3.9%
Sodium	0.17%	Sulphur	13.6%
Chloride	≤0.5%	Heavy metal	≤30ppm
Calcium	None	Loss on drying	≤5.0%
Packing way	O53	Packing size	10g/bottle
Danger classification	R21-25-36/37/38	Safety classification	S22-24/25-36-26
Application	Blood collection tube additive