Blood Anticoagulant Sodium Heparin Cas 9041-8-1

Potency of anticoagulant heparin sodiumAs an important factor to evaluate the quality of heparin sodium, the potency of heparin sodium is also the key to price judgment when purchasing. It mainly refers to the potency contained in every mg of heparin sodium. Assuming that the potency of heparin sodium is 150IU/MG, it means that every mg of heparin sodium contains a potency of 150IU.

If it is a 5ml blood collection tube, 100IU of heparin sodium needs to be added for anticoagulation. Usually, the higher the potency, the less the amount of heparin sodium added. Most of the market quotes are based on grams, which means the potency The higher the price, the more expensive it is. However, in the actual production process, there are many factors that will directly affect the potency of heparin sodium, so I will introduce it to you in detail next.

1. Effect of dissolution temperature and dissolution time on the potency of heparin sodium

Its potency usually shows a trend of first increasing and then decreasing with the continuous increase of temperature, and the potency can reach the highest value at a temperature of 40°C. If the temperature is too low during the production process, the crude product will take a long time to dissolve, which will lead to waste of production costs; if the temperature is too high, the activity will be destroyed, resulting in a sharp decrease in the potency of heparin sodium.

Heparin Sodium Parameters

2. Effect of salt concentration on the potency of heparin sodium

The anticoagulant is high-quality heparin sodium, which is usually extracted from crude heparin sodium. During the extraction process, it needs to be salted with a certain concentration of sodium chloride solution. If the concentration of the salt solution reaches the standard, the protein and heparin can be separated, but if it is too low, the separation will not be complete, which will affect the activity of heparin, and if it is too high, it will destroy the structure of heparin and directly affect the potency. Generally, when the concentration of the saline solution reaches 0.35mol/L, the titer of heparin sodium can reach the highest value.

3. Effect of thermal denaturation time on the potency of heparin sodium

With the continuation of thermal denaturation time, the titer first increased and then decreased. If the thermal denaturation process continues, impurity proteins will gradually denature as time goes on. When the time is too long, the structure of heparin at high temperature will be destroyed, which will affect the activity and cause the potency to gradually decrease. Note that the optimal heat denaturation time is about 10 minutes during the heat denaturation process.

4. Effect of the amount of hydrogen peroxide on the potency of heparin sodium

Too much hydrogen peroxide will destroy the molecular structure, reduce the activity of heparin sodium, and cause the titer to increase first and then decrease. Therefore, the optimal dosage of hydrogen peroxide is when the volume ratio of hydrogen peroxide to the volume of heparin sodium solution is 1%.

Desheng is a Chinese manufacturer of heparin sodium, the conventional potency is between 150IU-180IU, and it can be customized according to different needs of customers. At present, the sales volume of heparin sodium has occupied a place in the domestic market, and it is gradually expanding overseas, and has cooperated with many companies. If you have relevant needs, welcome to click the website to consult!