Mechanism Of Anticoagulant Effect Of Heparin Lithium As An Additive For Blood Collection

Mechanism Of Anticoagulant Effect Of Heparin Lithium As An Additive For Blood Collection

Heparin lithium, as a bioactive polysaccharide substance, mainly exists in the intestinal mucosa of pigs. It is a strongly negatively charged molecule and is widely used in the medical field due to its excellent anticoagulant properties. Its anticoagulant mechanism often involves multiple key links in the coagulation process. Let's take a look at the anticoagulant mechanism of heparin lithium together.

Heparin lithium data parameters

The impact of heparin lithium on the coagulation process can be roughly divided into three stages, as follows:

1. Influence on the formation of prothrombin kinase: prothrombin kinase is a key factor in the coagulation process, which promotes the formation of thrombin, thereby triggering blood clotting. One of the functions of heparin lithium is to inhibit the production of prothrombin kinase, mainly by enhancing the activity of antithrombin III. And antithrombin III is a natural anticoagulant protein that can quickly inhibit the production of prothrombin kinase, thereby slowing down the coagulation process.

2. Interfering with thrombin activity: Heparin lithium can interfere with thrombin activity, which catalyzes the formation of fibrin, leading to blood clotting. Heparin lithium interferes with the activity of thrombin factor, reduces the catalytic efficiency of thrombin, slows down the formation of fibrin, and thus inhibits the action of thrombin.

3. Preventing platelet aggregation: During the coagulation process, platelets gather together, and heparin lithium further achieves anticoagulation by preventing platelet aggregation.

Lithium Heparin

Heparin lithium has ideal anticoagulation performance, which is often used in clinical blood sample collection. However, it should also be noted that heparin lithium anticoagulation is non irreversible, so the blood sample needs to be tested within 6 hours, otherwise it may lead to abnormal results. At the same time, the heparin lithium in the blood sample needs to be thoroughly mixed with the blood sample to avoid partial coagulation.

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