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|CAS No:||77-86-1||Molecular Formula:||C4H11NO3|
|Molecular Weight:||121.14||Einecs No:||201-064-4|
Particular Trihydroxymethyl Aminomethane,
ISO9000 Trihydroxymethyl Aminomethane,
Where Else Can Trihydroxymethyl Aminomethane (77-86-1) Be Used As A Biological Buffer?
Trihydroxymethyl aminomethane (77-86-1) is usually white crystal particles, and the pH value of acid-base indicator is 7-9. It is an important organic chemical raw material and a common biological buffer. Because of its wide buffer range and good buffer effect, Tris has been expanding its application in the current research. Now there are many labels such as biological buffer, surfactant, vulcanization accelerator, pharmaceutical intermediates and so on.
|Melting point||167-172 ° C (lit.)|
|Boiling point||219-220 ° c10mmhg (lit.)|
|Density||1.353g / cm3|
|Vapor pressure||0.0267hpa (20 ° C)|
|Flash point||219-220 ° C / 10mm|
|Storage condition||2-8 ° C|
|Solubility H2O||4MAT 20 ° C, clear, colorless|
|PH||10.5-12.0 (4minwater, 25 ° C)|
|The pH range of acid-base indicator||7-9|
|Acidity coefficient (PKA)||8.1 (at 25 ℃)|
|Water solubility||550G / L (25 ° C)|
Tris is well known and widely used as a biological buffer. If you observe carefully, you will find that it also exists in other secret corners. It is said that Tris is widely used, but how widely is it? Now Desheng Xiaobian takes you to know about it!
Application of Tris in biological buffer
In the field of biological buffer, Tris buffer can be used for the formation of intermediate fiber of nematode laminin (using its low ionic strength), and can also be used as one of the main components of protein electrophoresis buffer; Tris can also be mixed with other solutions to form a new biological buffer. Generally, hydrochloric acid is added to adjust the pH value to the required value to obtain the buffer solution with this pH value. At the same time, we should pay attention to the effect of temperature on pKa of Tris.
Application of Tris in eye drops
Eye drops are one of the most commonly used drug formulations for ophthalmic diseases. For many eye diseases, eye drops have direct and rapid therapeutic effects. Due to the special anatomical and physiological characteristics of eyes, the corresponding requirements for ophthalmic preparations are put forward: the pH value of normal tears is 7.2-7.4, and the tolerable pH value range of normal eyes is 5.0-9.0. The pH value of eye drops will directly affect the eye irritation and curative effect of drugs. When preparing eye drops, buffers need to be added to adjust the pH value of the solution to make it roughly similar to tears, so as to reduce the eye irritation. At the same time, many factors such as drug solubility and stability should be taken into account when adjusting pH value. Tris is a common pH regulator in eye drops.
Application of Tris in nucleic acid detection
Nucleic acid detection is an important means to diagnose new coronavirus. What is the application of Tris in nucleic acid detection? Tris is an additive used in the virus preservation solution, which is the core material for nucleic acid detection. Tris can maintain the pH value of the sample in the virus preservation solution and act as a biological buffer. The virus and its nucleic acid are relatively sensitive to the environmental pH. the nucleic acid (DNA and RNA) is easy to hydrolyze in acidic solution and stable in neutral or weak alkaline solution. Its other function is to maintain the stability of the nucleic acid released after the sample is cracked, so as to avoid the degradation of nucleic acid, improve the concentration and purity of nucleic acid, and ensure the accuracy of subsequent nucleic acid detection and analysis.
Application of Tris in cosmetics
Tris is mainly used as a neutralizer in cosmetics. In fact, neutralizer is also a pH regulator. We all know that everyone's skin is different, and the suitable cosmetics are also different. The ingredients in many cosmetics are very complex. If you want a proper pH value, you must use tris to adjust, so that the ingredients of the whole raw materials will not change too much, and the cosmetics will be more gentle and not irritating when applied on the face.
Desheng technology is a professional manufacturer of biological buffers, Tris is the company's advantage product, purity ≥ 99%, high level, can be used in many fields. Spot supply, the average daily output of tons, interested can click the official website or call for advice.