China Wuhan Desheng Biochemical Technology Co., Ltd Company News

Hubei New Desheng Material Technology Co., Ltd. was established in 2017.It is a production enterprise specializing in R&D, production and sales of material for IVD reagent. At present, the company's products include  blood collection tube additives, biological buffers, chromogenic substrates, chemiluminescence reagents and enzyme preparations. In terms of blood collection tube additives, it has formed independent intellectual property rights and professional production and R&D capabilities.   At present, our company mainly has a series of blood collection tube additives, including sodium heparin, lithium heparin, trisodium citrate, dipotassium EDTA, tripotassium EDTA, potassium oxalate, blood coagulation powder, blood coagulant, serum separating gel, silicifying agent,etc. The raw materials of diagnostic reagents include biological buffers and chromogen substrates. At present, chromogen substrates,also known as new Trinder's reagents, include TOOS, TOPS, ADOS, ADPS, ALPS, DAOS, HDAOS, MADB, MAOS, TODB, etc.They are white,which are different from light blue or brown products on the market.White crystal biological Buffers include TRIS, HEPES,BICINE,CAPS, MOPS, TAPS, EPPS, etc. Which max absorbance is 0.05.Self-developed chemiluminescence substrates include luminol, isoluminol, acridine ester and enzyme substrate PNPG,all with high purity.   The company focuses on the blood test reagent industry, and is determined to become the world's leading brand and contribute to the human health. Since its establishment, the company has always adhered to the core business philosophy of "morality-based, honesty-first", and regards providing value to customers as our responsibility, which has been well received by customers.   The product quality and technology of New Desheng have been widely recognized and used by customers in the Chinese domestic market. Over the years, many well-known blood collection tube manufacturers in China have been choosing our products.Desheng Technology will continue to devote to develop the advanced material for IVD reagents to meet the needs of the development of global medical testing technology and strive for the human health.Welcome your inquiry on related products.

The Chinese name of CAPS is 3-(cyclohexylamine)-1-propanesulfonic acid. It is a white crystalline powder with a molecular formula of C9H19NO3S, a molecular weight of 243.28, and a CAS number of 1135-40-6. It is a commonly used biological buffer.   Different usage have different requirements for the purity of caps. When used as a biological buffer,generally high purity as analytical grade (AR grade) of CAPS are chosen.When used in industrial production, the purity requirements are not so high.So the usage should be clear when select CAPS powder.The biological buffers CAPS produced by Desheng are of analytical grade.We strictly controlled the production quality,and the purity higher than 99%.   CAPS has a wide range of applications as biological buffers, such as in biochemical diagnostic kits, DNA/RNA extraction kits and PCR diagnostic kits. And CAPS also has many applications in industry, such as new coatings and new materials.   Desheng Biochemical has been developing and producing biological buffers for many years with rich experience.CAPS is one of the core products, which is well received in the field of biochemical diagnostic reagents and the new coating products market. It has been more than ten years since Desheng was established. The company's products are sold all over the world. At present, it has been sold to more than 100 countries around the world with good quality and favorable price.Welcome your inquiry!

The Chinese name of HEPES is 4-hydroxyethylpiperazine ethanesulfonic acid, which is a biological buffer with a wide range of uses. Perhaps when it comes to biological buffers, the first thing that comes to mind is its application in biochemical experiments, which is far from our daily life. In fact, if you carefully observe the commonly used skin care products and cosmetics, you will find that there are 4 - Hydroxyethylpiperazineethanesulfonic acid in these ingredient.   Due to the special buffer range of HEPES, it has an irreplaceable position in the field of industry, cosmetics and biochemical experiments. So how is it produced? The editor summarizes a method for preparing HEPES here, let's take a look.   Preparation steps of HEPES powder: 1.Vinylsulfonic acid or vinylsulfonate and N-hydroxyethylpiperazine addition reaction to prepare 4-hydroxyethylpiperazine ethanesulfonate; 2.4-hydroxyethylpiperazine ethanesulfonic acid salt is converted into the salt of 4-hydroxyethylpiperazine ethanesulfonic acid and corresponding acidifying agent with acidifying agent, obtains acidifying liquor; 3.The acidified liquor is crystallized, and the salt content of the corresponding acidulant is removed to obtain the treated acidified liquor; 4. Add soluble barium salt or calcium salt to the acidified liquor, remove residual sulfate, evaporate and concentrate to obtain HEPES primary purified product; 5. The primary purified product is washed with small molecular alcohol and dried to obtain high-purity HEPES powder.   This method can not only produce high-purity HEPES, but also has low purification cost, simple preparation process, easy operation and no pollution. Desheng Biochemical is a source manufacturer of biological buffers. Since established in 2005, it has rich experience in the research and production of biological buffers. At present, there are more than ten kinds of biological buffers produced. Welcome to inquiry.

Chromogen substrate can actually be divided into general-purpose chromogenic reagents and exclusive chromogenic reagents. According to different classifications, there are many exclusive chromogenic reagents,such as hydrocarbons, organic acids, phenols, steroids, chlorine-containing compounds.,etc.What I want to talk about today is the new Trinder's chromogen substrate .   The new Trinder's chromogen substrate is both a nitrogen-containing compound and a fragrant compound.The reaction is generated by the binding of horseradish peroxidase to achieve the purpose of color reagent. Corresponding to Trinder's chromogen substrate, there is also tetramethylbenzidine chromogenic system. In terms of time, Trinder's chromogenic reagent actually developed later than TMB. Currently, TMB is used more as color reagent in China.   Although Trinder's reagent was developed and used later than TMB, it was not so smooth in the initial period. The stability and sensitivity of chromogen substrates are two key points,but the new Trinder's reagent was not as good as TMB in the early stage. Today, the data of Trinders reagent is more dazzling, but the cost is still higher than TMB, so this is also an important reason for the delay in comprehensive coverage.   The advantages of the new Trinder's chromogenic reagent is that is easier soluble in water and all sublimation reactions are carried out in water.What’s more,its own physical and chemical properties are changed.However, the TMB is difficult to dissolve in water. In terms of use, it is still necessary to choose products according to the special circumstances of the manufacturer.   Desheng company is established in 2005 to develop biochemical reagent.We have five star series including the new Trinders chromogen substrate. The results of various comparisons show that our product quality is relatively outstanding which won many appreciations from customers.   Except the new Trinder's reagents,we also produce TMB series. The direct selling price of the factory is more favorable, and the quality of the products is guaranteed. Desheng insists on winning by quality, and provides customers with the best quality and the most considerate service.If you need them,pls contact us!

When the coagulated blood are centrifuged in the test tube, a medium is required to separate the serum and the blood clot, which forms a gel-like separation layer between the serum and the blood clot, and this medium is serum separation gel.   After the blood is centrifuged in the separation gel accelerator tube, it will be divided into three layers, the top layer of pale yellow liquid is serum, its specific gravity is between 1.02-1.03. The bottom layer is blood clot, its specific gravity is 1.08-1.09.Compared with the gravity, the blood clots is much higher than serum, and the specific gravity of serum separation gel is between 1.050-1.060, which is just between the serum and blood clot.   The separation gel produced by Desheng now has two kinds with national patents, one is polyacrylic acid separation gel; the other is resin separation gel based on polyacrylic resin as monomer. There are translucent,opaque and unique transparent.For the appearance, specific gravity and viscosity, we can customize the separation gel according to the requirements.   The anti-irradiation serum separation gel produced by Desheng has stable effect and strong thixotropy, which can effectively prevent the exchange of hemostatic cells and serum substances. It will not affect the stability of the composition of the serum within a certain period of time. It can also produce stable effects when used with other blood collection tube additives such as coagulants and anticoagulants according to the detection requirements. The anti-irradiation serum separation gel is used with a coagulant to quickly obtain serum samples, and the processed blood samples will not affect the test results of the samples after long-term transportation or bumps.   After 16 years of development, Desheng's serum separation gel has developed to the fourth generation, from the previous generation that is not radiation resistant to the current resin system that is resistant to radiation, which is already ahead of most domestic manufacturers. Desheng has a dedicated R&D team for separating gel technology. The price is very competitive with good quality. Now the daily output can reach 2-4 tons. The production process equipment is advanced, the delivery is timely, and the spot supply is guaranteed.Welcome to inquiry.

Most people knows the key role of carbomer in daily used cosmetics. It is an important ingredient that has good performance and can produce high viscosity in a small amount. Only need about 0.2% of carbomer to the skin care product lotion we usually use,a good thickening effect will be taken. But if it is used in gel cream, the amount will be relatively increased to achieve a good thickening effect.   What exactly is carbomer made of, and why does it have such a good thickening effect? In appearance, it is a white loose powder with strong hygroscopic properties,composed of a copolymer of polyalkylsucrose or polyalkylpentaerythritol and acrylic acid cross-linked polymer (acrylic acid or acrylate).   In the case of a dry powder, the carbon chain of the acrylic molecule is relatively tightly packed. Once dissolved in water, its molecules will slowly disperse and form hydrated molecules with water molecules. At this time, the closely connected carbon chains will disperse, resulting in high viscosity. The larger the hydrated molecules are, the greater the viscosity.   However, water cannot fully expand the molecule, and some neutralizing agents are needed to achieve a good expansion state, such as sodium hydroxide or green amine. If the carbomer is not dissolved in water, but is dissolved in a polyhydric alcohol or a polyethyl solvent, the hydrogen bond between the carbomer molecule and the solvent can be generated without adding any other neutralizing agent, resulting in a strong thickening and suspending properties.   Desheng Biochemical is a manufacturer specializing in the production of carbomer. The carbomer developed and produced has high purity, good water solubility, stable process and small batch-to-batch variation. With high daily output and stable supply,a large number of new and frequent customers have accumulated repurchases. If necessary, welcome to consult and order.

Facial skin care products and sunscreen products account for 65% and 10% respectively of the skin care products retail market. This market is developing very fast with increasingly fierce competition and sophisticated consumers. Consumers who value time have been looking for high-efficiency and multifunctional products.High cost efficiency can not only save money, but also greatly save the time for skin care. The fiercely competitive market drives brands to look for better solutions. Especially popular brands, hope to promote their brand value in their cost-effective and multifunctional products.Carbomer polymers 940 play an important role in the personal care industry.   With different structures, Carbomer polymers 940 can provide functions such as thickening, changing rheological texture, emulsification stabilization, film-forming, regulating skin feel, and improving skin. In order to provide all of the above functions and make it easy to use. Desheng has made this idea a reality, let's take a look at what properties this polymer can bring to your skin care, sunscreen and makeup formulations.Carbomer polymers 940 is an all-in-one functional product for the development of skincare, makeup and sun protection products with broad compatibility, high functionality and a soft, powdery finish.   Features and Benefits: ✔ Has multiple functions ✔ Special skin feel characteristics: soft, powdery after-feel ✔ Emulsifying performance is not affected by HLB value ✔ Only 1% dosage can provide efficient film-forming properties, improve skin barrier and reduce skin moisture loss ✔ Compatible with high levels of metal oxides and clays such as 17% kaolin ✔ Diverse feeling experience ✔ The polymer exhibits a longer Newtonian fluid phase, resulting in a thicker, more homogeneous film on the skin ✔Polymer provides shear thinning properties for good skin spreading. Compounding with co-thickeners can increase yield for good stability.   Precautions ● In order to prevent the product from foaming, the stirring speed should be low speed to prevent the introduction of air. ● Carbomer polymers 940 can be pre-formulated with humectants as dispersions (polyols, etc.). ● Carbopol polymers 940 have the ability of shear thinning, and the longer the shear time is, the slower the viscosity recovery will be, and even cause the permanent loss of viscosity. ● Carbomer polymers 940 is not affected by temperature, does not support the growth of microorganisms and molds, and does not have surfactant properties. ● UV irradiation will cause irreversible loss of viscosity of Carbomer polymers 940 .   Desheng Carbomer polymers 940 can provide the functional of emulsion stability, rheology modification, film formation, toner dispersion, etc. Now the products have been sold all over the world, and have been unanimously praised after testing. If you are looking for direct manufacturer of carbomer , welcome to contact us.

CAPS, also known as 3-cyclohexylaminopropanesulfonic acid, is a biological buffer with white crystals powder in appearance. CAPS can be dissolved in water and the pH buffer range is 8.9-10.3.Its PKA value is 9.6 when the temperature is below 25°C, and the molecular weight is 243.28.The CAS number OF CAPS is 1135-40-6.What Are CAPS Buffer Can Be Applied In?Actually, CAPS has a wide range of applications, including DNA/RNA extraction kits, PCR diagnostic kits, biochemical diagnostic kits, manufacturing welding materials, air conditioning equipment, manufacturing metal lithium, new coatings, and new industrial materials.   In nucleic acid extraction, it can be combined with 3-[(3-cholamidoendyl)dimethylammonium]-1-propanesulfonate (CHAPS), 3-(cyclohexylamino)-2-hydroxy-1- propanesulfonate (CAPSO), and 2-(cyclohexylamino)ethanesulfonate (CHES),together to prepare a solution for nucleic acid hybridization. It can reduce the yield of non-specific hybrids and improve the specificity of nucleic acid hybridization, while maintaining the yield of target hybrid products, which is of great value in the identification of specific pathogens, the diagnosis of genetic disorders, and the analysis of DNA sequences.   CAPS can be used in various environmentally friendly and high-quality waterborne component polyurethane coatings, and can coexist stably with resins containing active DNA (hydroxyl, carboxyl, amine, epoxy, etc.) for a long time at room temperature. The application of CAPS in coatings is widely used by the waterborne coatings market. In addition, CAPS and aliphatic polyisocyanates can react in the presence of tertiary amine neutralizing agents under mild conditions. The resulting sulfonic acid urea derivatives are very good emulsifiers.   CAPS can be used to prepare the running buffer (also known as electrolyte solution) in capillary electrophoresis, and as the end electrolyte to make the electrokinetic pressurized online enrichment and separation of 2-nitrobenzoic acid and 3-nitrobenzoic acid. The CAPS buffer is suitable for running buffers of high molecular weight proteins (greater than 20KD). If it is a low molecular weight protein blotting experiment, combined Tris with Glycine is generally used, and if glycine is excluded by protein sequencing, Tris-Tricine and EDTA is used.   CAPS can also be used in biochemical diagnostic kits, DNA/RNA extraction kits and PCR diagnostic kits, as buffers for enzymatic chemistry and HPLC separation of alkaline drugs. CAPS can be used as a western blot transfer buffer or transfer buffer in the transfer process of protein sequencing. CAPS can also support alkaline phosphatase activity and suppress the growth of aeromonas at pH 105.After dissolving in deionized water and adjusting the pH to 110 , it was used for the purification of fibronectin. In addition, CAPS is also used as an eluent in cation exchange chromatography,as a raw material in manufacturing welding materials for air conditioning equipment. What’s more,It can also be used to make fireworks, used as analytical reagents, heat exchange carriers,etc.   Desheng have been developing and producing biological buffers for many years with rich experience.CAPS is one of our key products sold well in the market,inquiries are welcome if you have any requirements.

Labeling principle of chemiluminescence substrate acridinium ester in diagnostic reagents in chemiluminescence immunoassay, we label the antibody protein with acridine ester at first, so that the analyte can be detected after the immune reaction. In that case,how to label the antibody is very critical.Acridine salts and related compounds have been widely proven to be very useful chemiluminescent labels, surpassing radioisotopes in stability, label specificity, and detection sensitivity.The acridine-NHS ester, also name as acridine succinimide ester, can reacts with the primary amino groups of proteins. Under alkaline conditions, NHS is substituted as a leaving group and the protein forms a stable amide bond with the acridine ester. After the reaction was completed, the excess acridinium salt was removed through a desalting column. In the presence of alkaline hydrogen peroxide, acridine-labeled proteins can emit light without enzymatic catalysis.   Therefore, the addition of the excitation solution causes the reaction system to release photons at about 430 nm immediately, and the protein concentration can be detected by counting the number of photons with a standard luminometer. Because this luminescence process is completed within 2 seconds, the sample must be placed directly in front of the photon detector inside the photometer. Proteins, polypeptides, antibodies, and nucleic acids can all be labeled with acridine esters.   What should be noted for chemiluminescence reagent is dissolving acridine succinimide ester with strictly anhydrousstrictly anhydrous DMF to prevent the acridine ester from being hydrolyzed. And it should be stored in a dry seal at -20°C when not in use.Different from traditional acridine ester,the structure of acridine succinimide ester has been modified to increase the steric hindrance and enhance the hydrolysis resistance.It can be stable at PH buffer solution at room temperature with PH 7.0.   If the acridine carboxylic acid without -NHS, it is necessary to add a condensing agent such as EDCI, etc., in order to have a coupling reaction with an amine group-containing protein. Acridine hydrazide, containing free amino group, is suitable for direct coupling of polysaccharide nucleic acid or protein containing aldehyde group at the end of acridine hydrazide.   Desheng has been developing and producing in vitro diagnostic reagents for blood detection since 2005. It has in-depth research on blood collection tube additives, chromogen substrates (new Trinder's reagents), biological buffers and chemiluminescence reagents. It has a professional R&D team and production equipment. At present, the company's production equipment and production processes are all newly upgraded. Welcome Inquiry.

When it comes to EDTA, many people should have heard of it. Today, I will introduce two potassium salts used as blood coagulants in blood collection tubes.   Dipotassium ethylenediaminetetraacetate, alias: dipotassium EDTA, CAS number is 25102-12-9, molecular weight is 404.46g/mol,and molecular formula is C10H18K2N2O10.Dipotassium EDTA is actually used as an additive in vacuum blood collection tubes, in the preparation of toilet deodorants, as a complexing agent in liquid phase analysis, and in the preparation of metal polishing agents.   Tripotassium ethylenediaminetetraacetate, alias: Tripotassium EDTA, CAS number is : 65501-24-8,molecular weight is 442.54g/mol,and molecular formula is C10H13K3N2O8.The tripotassium EDTA is used for complexing metal ions and separating metals, preparing anticoagulants in anticoagulant tubes; also used in detergents, liquid soaps, shampoos, agricultural chemical sprays Antidote,etc.   Dipotassium EDTA and tripotassium EDTA are both commonly used as anticoagulants in blood collection tubes.The anti-coagulation principle is EDTA chelates calcium ion in the blood to make anti-coagulation effect.Both are white crystalline powders soluble in water and alcohol.   Although both used as blood collection tube anticoagulants,their anticoagulant abilities are different, mainly in the ability to complex calcium ions cause tghe different usage.In 5% aqueous solution,the pH of EDTA-Ka2 is 4.8 ± 1,and EDTA-Ka3 is 7.3 ± 1. The difference is mainly reflected the stability at different pH condition.The PH of EDTA K3 is neutral that won’t affect the PH of blood.At the same time, its ability to complex calcium ions is stronger than that of EDTA K2.Which reflect the anticoagulant effect is better than that of EDTA K2; What’s more,the solubility of EDTA K3 is higher than that of EDTA K2, which sometimes affects the anti-coagulation effect.But if EDTA K3 is used as a liquid additive, it will cause dilution of the sample. All direct test items, such as hemoglobin, red blood cell, white blood cell, and platelet counts, were 1-2% lower than EDTA K2 as an anticoagulant.   It seems that there are advantages and disadvantages to choose EDTA K2 or EDTA K3 as blood collection tube additives.The important thing is to choose the right one for the detection. Hubei New Desheng is a professional manufacturer of blood collection tube additives. We have been producing these for more than ten years with mature production process and excellent technical indicators.We are worthy of your trust!

Carbomer, which contains a variety of cross-linked acrylic polymers and copolymers, is one of the basic ingredients in many daily products, from cosmetic to personal care products to printing inks, paint adhesives and industrial supplies.Since the development and production of carbomer, many industries have relied on carbomer to increase the viscosity of products,form gels,stable emulsions and suspended particles. In addition, it has the characteristics of improving product quality and improving long-term stability of shelf products. Carbomer is also known as the "best friend of formulator's ".   The main component of carbomer is poly acrylic acid,which is synthesized by free-radical precipitation polymerization in organic solvents. The solvent of this process makes monomers, initiators and other additives soluble in the reaction medium, but the reacted polymerization product is insoluble. According to the record, benzene was used as the preferred solvent for the synthesis of carbomers, but it was unfavorable to health and safety concerns.Now alternative solvent systems such as a mixture of ethyl acetate and cyclohexane are used.   Preparation method of carbomer: 1.Dissolve acrylic acid and a small amount of TAPE and potassium carbonate (K2CO3) in ethyl acetate or cyclohexane co-solvent.K2CO3 is added to the acrylic acid to neutralize a small fraction of the acrylic acid groups to help facilitate precipitation of the reacted polymer in the co-solvent system. 2. Heat the mixture to 50°C under a nitrogen atmosphere and slowly add a peroxy initiator such as bis(2-ethylhexyl) peroxydicarbonate to the reaction vessel within 6 hours . 3. With the progress of the polymerization reaction, the insoluble carbomer product is precipitated from the solvent to form a slurry of carbomer particles in the solvent. 4. After the reaction is complete, the carbomer is separated from the slurry and the polymer solids are dried to yield the carbomer product in powder form.   Hubei New Desheng is specialized in carbomer powder likd carbomer 940/980,U20,U2020,etc.Pls feel free to contact us if you have any requirements.

Carbomer is a very viscous thickener that can effectively build viscosity in aqueous systems at lower concentration.Most carbomer can make 10,000–60,000 cP at only 0.5% w/w viscosity, so carbomer is often used as an aqueous thickener in various products. When preparing the carbomer solvent, it should be taken care to disperse the carbomer powder to avoid agglomeration to form granular fish-eyes, resulting in inability to dissolve.   In the preparation of carbomer gel, dispersion is a crucial step, which usually requires the powder to be slowly sprinkled into the dispersion medium and stirred rapidly. For large-scale gel preparation, a powder disperser can be used to assist. Most of the carbomers on the market today are easier to disperse than traditional ones, reducing the complexity of dissolution,and incorporated steric stabilizers that is ethoxylated nonionics with a block or comb configuration during precipitation polymerization surfactant.The finished carbomer is easily soaked when added to an aqueous medium, but hydrates slowly, allowing for a smooth, uniform dispersion of the carbomer.   Because it dissolves slowly by hydration, the powder is usually added to the aqueous medium at first,stand overnight for fully water absorbing.When the gel is prepared by stirring and mixing the next day, it will be easier to achieve good effect. Desheng is a professional manufacturer of carbomer.At present, we have carbomer 940, carbomer 980,carbomer U20,etc.Our average daily mass production of about 3 tons,which guarantee the delivery in time.And we have a professional after-sales team to support. Now you can apply for a sample online for a trial.