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Biological Buffer PEP Powder,
High Purity White PEP Powder
|Product name||Phosphoenolpyruvic aicd Tris(cyclohexylammonium) salt|
|CAS No||35556-70-8||Appearance||white powder|
|Molecular weight||603.3||Molecular formula||C21H44N3O6P|
|Storage condition||room temperature, in dry and dark place|
The purity is >99%, with good water solubility and stable process, which can ensure that the product appearance is pure white crystal powder.
Phosphoenolpyruvate (PEP) is a glycolytic metabolite with high-energy phosphate group. PEP (0.1-10 mm) significantly reduced the decrease of cell viability induced by hydrogen peroxide (H (2) O (2)) in HeLa cells in a dose-dependent manner. PEP also inhibited the decrease of cells stained with calcein acetomethoxy and the increase of cells stained with propidium iodide induced by H (2) O (2). Hep (2) O (2) stimulated the increase of intracellular reactive oxygen species.
PEP is a functional carbohydrate metabolite with cell protection and antioxidant activity, and may be used as a therapeutic agent for diseases involving oxidative stress. However, there was no effect at low dose (0.1, 1 mm). PEP (0.1-10 mm) also reduced cell damage, but did not decrease the intracellular ATP content induced by glycolysis inhibitor 2-deoxy-D-glucose.
PEP also reduced the leakage of aminotransferase and LDH during 72 h organ preservation, histological changes and oxidative stress parameters (measured by thiobarbituric acid reactive substances and glutathione content). The effect is comparable to that of the University of Wisconsin solution, a gold standard organ preservation agent. PEP treatment can reduce the decrease of ATP content in liver during cold storage. PEP can prevent cell damage and increase the content of ROS in HepG2 cells. In addition, PEP scavenged hydroxyl radicals, but had no effect on superoxide anion, which was evaluated by spin trapping technique of EPR.
Product quality and customer service of product buffer PEP produced by Desheng have been recognized by many customers and established as long-term suppliers.
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