China Wuhan Desheng Biochemical Technology Co., Ltd Company News

In the golden September, Yangcheng gathers. From September 26th to 29th, 2025, the global healthcare industry will once again focus on Guangzhou, welcoming the grand opening of the 92nd China International Medical Equipment Fair (CMEF). As an innovative force in the field of core raw materials for in vitro diagnostics (IVD), Hubei Xindesheng Materials Technology Co., Ltd. is ready to go. Led by the company's general manager, an elite team consisting of technical elites and domestic and foreign sales backbones set off from Hubei on September 25th to attend this top-level industry event (booth number: C06 in Hall 20.1), aiming to present a precise diagnostic technology feast to global customers with a series of innovative enzyme preparations and mature core products. 1, Innovation engine: New enzyme preparations make a heavyweight debut, empowering precise diagnosis in new dimensions At this year's CMEF, Xindesheng will launch a new generation of high-purity and highly stable enzyme preparation series that it has carefully developed, including key indicator detection materials such as lactate dehydrogenase (LDH), uricase (UO), creatine kinase isoenzyme (CK-MB), etc. These new products are not only a concentrated reflection of the company's research and development capabilities, but also directly address the higher demand for detection sensitivity, specificity, and inter batch stability in the current IVD testing market. These new enzyme preparations have injected strong power into Xindesheng's "innovation engine", indicating that the company has taken a more solid step on the road of independent research and development of key raw materials, aiming to help downstream reagent manufacturers enhance their product core competitiveness. 2, Stable cornerstone: Core product matrix appears together, showcasing the full chain supply strength While showcasing its innovative edge, Xindesheng will also showcase its traditional core product matrix that has been validated in the market for a long time, demonstrating its comprehensive strength as a reliable supplier. Biological buffering agents, such as Tris, HEPES, Bicine, etc., have excellent purity and provide a stable reaction environment for diagnostic reagents. Chemiluminescent reagents, including luminol and acridine ester luminescent reagents, have the advantages of high luminescence efficiency and sensitive reaction. Chromogenic substrates such as TOOS, TOPS, MAOS, MADB, etc. are sensitive and stable for color development, and are suitable for various enzyme immunoassay analyses. Blood collection tube additives: a full range of products including serum separation gel, anticoagulant, coagulant, silicification agent, etc., provide support for front-end sample processing. New Desheng's product line covers multiple key aspects of IVD reagent development and production, including reaction environment construction, signal generation, and sample preprocessing, demonstrating its strong ability to provide customers with a "one-stop" raw material solution. 3, Face to face communication: Elite teams gather to discuss new chapters of cooperation In this exhibition, Xindesheng not only sent out products, but also a powerful "think tank" and "service team". The general manager, technical experts, and domestic and foreign sales elites gather together to have zero distance and in-depth communication with customers and partners from around the world. Whether it's exploring cutting-edge technology trends, analyzing specific project requirements, or negotiating customized services and international market cooperation, the New Desheng team is fully prepared and looks forward to colliding ideas and listening to market voices on the open platform of CMEF. With more flexible and thoughtful services, we will explore the infinite possibilities of diagnostic technology development together with industry colleagues. Conclusion: At the right time for the grand event, Xindesheng is waiting for your visit in Guangzhou! The exhibition has now grandly opened, and excitement is unfolding! The booth of Hubei Xindesheng is ready, and our team is eagerly awaiting the visit of all new and old friends in Guangzhou with full enthusiasm. Now, by visiting the New Desheng booth (booth number: C06, Hall 20.1), you will be able to: Personally observe and understand the appearance and excellent performance of new enzyme preparations and core products; Face to face with the general manager and technical experts to deeply discuss your customized needs and technical challenges; Obtain the latest product information and cooperation policies. The opportunity is rare, and the grand event is in full swing! We look forward to meeting you in Yangcheng, seeking common development and a win-win future!

On September 19, 2025, the golden autumn brings a refreshing feeling and the fragrance of osmanthus flowers fills the air. In this beautiful season of harvest and hope, we warmly welcome our important strategic partner from afar - Ms. Anu Moturi, founder of Kriya Medical Technologies (KriyaMed), an Indian blood collection industry enterprise. This visit is a deep interaction between the two sides after embarking on a journey of cooperation, aimed at reviewing the fruitful cooperation process and jointly drawing up a grand blueprint for future development. During the visit, both parties held talks on the in-depth cooperation and future market strategy of EDTA K3 and separation gel, and conducted on-site inspections of our new Huanggang factory. Both sides walked together, sharing their cooperative friendship and seeking common development plans, creating a warm and harmonious atmosphere on site. Under the leadership of founder Anu Moturi, KriyaMed has become an undeniable force in the Indian blood collection tube market. Since establishing a partnership with our company 6-7 years ago, both parties have supported each other and grown together. Ms. Anu Moturi's personal visit this time not only reflects her appreciation for the long-term cooperative relationship with our company, but also demonstrates her firm determination to further deepen cooperation and jointly explore the market. At the beginning of the visit, our company's Chairman Mr. Wang Zhongxi, General Manager Ms. Wang Anqi and other senior leaders expressed their warmest welcome to Ms. Anu Moturi's visit. During the cordial and friendly talks, both sides jointly reviewed the achievements of their cooperation over the past five years. Ms. Anu Moturi expressed her sincere gratitude to our company for providing stable and high-quality product supply, as well as timely and professional technical services. She clearly stated that one of the core objectives of this visit is to explore with our company a more competitive cooperation price for EDTA K3 anticoagulant and core raw material separation gel based on a larger procurement scale in the future, in order to further enhance the competitiveness of KriyaMed products in the Indian market. More notably, Ms. Anu Moturi confidently shared KriyaMed's next strategic development plan. She announced that the company has set clear goals to significantly increase the production capacity and market share of separation gel blood collection tubes, striving to become the leader in the Indian separation gel blood collection tube market. To achieve this ambitious goal, KriyaMed plans to increase its procurement of separation gel from our company on one hand, and on the other hand, invest heavily to enhance its own production capacity. She emphasized that establishing a deeper strategic alliance with our company, a source enterprise with strong technology and production capacity guarantee, is the core cornerstone to achieve this goal. In order to enable our esteemed partners to fully understand our strength and commitment, Mr. Wang Zhongxi, Chairman, and Ms. Wang Anqi, General Manager, personally accompanied Ms. Anu Moturi to visit and inspect our new factory located in Huanggang. On this trip, she not only saw the strong existing production capacity of your company, but also saw the huge development potential for the future. She highly appreciates our company's continuous investment in production capacity and technological upgrades, believing that this provides a solid and reliable guarantee for its future large-scale procurement needs, and is full of confidence in the stability and growth of our long-term cooperation. The successful visit of Ms. Anu Moturi marks a new and deeper stage in our partnership with KriyaMed after five years of testing. From stable suppliers to strategic partners working together, this transformation is based on deep mutual trust and a shared vision. We firmly believe that with Ms. Anu Moturi's outstanding leadership and clear market strategy, the strong alliance between the two parties will bear even more fruitful results. Hubei Xindesheng will spare no effort to support Kriya Medical Technologies in achieving its grand goal of becoming a market leader in India with competitive prices, stable product quality, and a reliable supply chain, and jointly create a mutually beneficial and win-win future!

In life science research, the pH stability of the experimental environment is a core factor affecting cell activity, enzyme catalytic efficiency, and protein structural integrity. As a classic buffer in the neutral to weakly alkaline range, 3- (N-morpholino) propanesulfonic acid (MOPS buffer) is widely used in fields such as cell culture, protein purification, and nucleic acid electrophoresis due to its excellent buffering capacity and biocompatibility. However, the concentration control of MOPS directly determines its buffering efficiency, and improper concentration may cause experimental deviation or even failure. 1, Dynamic balance between concentration and buffering capacity The buffering capacity of MOPS originates from the protonation deprotonation equilibrium between the sulfonic acid groups in its molecular structure and the morpholine ring. When the concentration of hydrogen ions in the solution changes, MOPS maintains pH stability by releasing or absorbing protons. Experiments have shown that the buffering capacity of MOPS is positively correlated with concentration within the range of 10-100 mM. For example, in protein ion exchange chromatography, a 10 mM MOPS buffer may result in a decrease in the separation between target proteins and impurity proteins due to insufficient buffer pairs; And 50 mM MOPS can achieve efficient separation of target proteins under specific elution conditions by precisely regulating the pH value of the mobile phase.But the higher the concentration, the better. When the concentration of MOPS exceeds 200 mM, the number of buffer pairs tends to saturate, and the effect of increasing concentration on pH stability significantly weakens. It may even interfere with the binding of proteins to chromatographic media due to high ion strength. In addition, high concentrations of MOPS may alter the fluidity of lipid membranes, affect the permeability of cell membranes, and thus interfere with the results of cell culture experiments. 2, Concentration sensitive window in cell culture Mammalian cells are extremely sensitive to the pH value of the culture medium, and MOPS, as a commonly used buffer component, should be strictly controlled at a concentration below 20 mM. Research has found that when the concentration of MOPS exceeds 20 mM, the thickness and barrier properties of the surface layer of rat endothelial cells change, resulting in a 15% -20% decrease in the efficiency of glucose uptake by cells. In addition, high concentrations of MOPS may interfere with the differentiation potential of embryonic stem cells by affecting calcium channel activity. 3, Practical points of concentration control Gradient testing method: For specific experimental systems, 5-10 MOPS concentration gradients (such as 5-100 mM) are pre designed, and the optimal concentration is determined by monitoring indicators such as pH stability, cell activity, or protein recovery rate. Compatibility verification: When using new chromatographic media or cell lines, it is necessary to verify the compatibility of MOPS concentration with the experimental system. For example, some metal chelation chromatography media may experience a decrease in performance due to the weak chelation of MOPS. Dynamic adjustment strategy: For long-term experiments (such as continuous cultivation or long-term electrophoresis), the effective concentration of MOPS can be maintained by adding buffer solution in stages to avoid pH loss due to buffer consumption. MOPS concentration control is a key link in the precision of life science experiments. By understanding the quantitative relationship between concentration, buffering capacity, and biological effects, and optimizing the buffering system based on specific experimental requirements, the reliability and reproducibility of experimental results can be significantly improved. In the future, with in-depth research on the interaction mechanism of MOPS molecules, concentration control strategies will become more refined, providing technical support for high-quality development in fields such as biopharmaceuticals and synthetic biology. Desheng is a professional manufacturer of biological buffering agents, established for more than ten years. It has rich experience in research and development, production, and product knowledge, and can provide customers with a large amount of technical support and after-sales guarantee. The biological buffer products currently produced include MOPS, TRIS, HEPES, TAPS, CAPS, BICINE, EPPS, PEP and a series of other biological buffer solutions. If you need them, please feel free to contact us at any time!      

In biochemical and molecular biology experiments, the stability of buffering agents directly affects the reliability of experimental results. PIPES, as a commonly used biological buffer, has attracted much attention for its chemical stability. The stability of PIPES buffer is particularly outstanding at room temperature and neutral pH environment. In a solid state, it can be stored for several years in a dry place at room temperature after sealing without significant degradation. When in solution state, within its effective buffering range, it can be stabilized for several weeks at 4 ℃ refrigeration and maintained for 1-2 weeks at room temperature. The degradation products are minimal, mainly trace amounts of piperazine derivatives. This provides convenience for experimental operations and reduces the hassle of frequently preparing buffer solutions. The temperature has a significant impact on the stability of PIPES. When heated for a short period of time at 60-80 ℃, its structure is basically stable and can meet the needs of some mild heating experiments. But do not perform high-pressure sterilization, as high temperature and pressure can cause slight decomposition, producing by-products such as piperazine and sulfonic acid. This not only reduces buffering capacity, but may also release trace amounts of harmful substances that affect biological samples, such as cells and enzymes. In terms of lighting, PIPES is relatively stable to ordinary indoor lighting, but long-term exposure to strong light (such as ultraviolet light) may result in slow degradation due to photooxidation. Therefore, the solution needs to be stored in a brown bottle away from light to delay the degradation process. PIPES exhibits good compatibility in interactions with chemical substances. It is relatively stable against common oxidants and not easily oxidized; Not sensitive to reducing agents and can coexist with sulfur-containing reducing agents, suitable for experiments that require a reducing environment, such as protein purification. More importantly, its coordination ability with most metal ions (such as Na ⁺, K ⁺, Ca ² ⁺, Mg ² ⁺) is weak, making it difficult to form stable complexes. This characteristic gives it a significant advantage in reaction systems containing metal ions (such as enzyme reactions and cell culture), and it will not interfere with experiments due to chelation of metal ions. This is a major highlight compared to buffering agents such as BICINE and HEPES. There are three main degradation pathways for PIPES: under strong acidic (pH12) conditions, the bond between the sulfonic acid group and the ethane group may break, releasing sulfonic acid groups and piperazine derivatives; When the temperature exceeds 100 ℃, the piperazine ring may partially open, producing amine and carboxylic acid by-products; Under UV irradiation, it may cause oxidation of the piperazine ring, resulting in the formation of imines or hydroxyl derivatives. Although degradation products are usually not highly toxic, they can reduce buffering capacity and extreme conditions should be avoided. In practical applications, controlling stability is crucial. The solution is recommended to be prepared and used immediately. If storage is required, it can be adjusted to pH 6.5-7.0, stored at 4 ℃ in the dark, and avoid repeated freezing and thawing. If aseptic treatment is required, 0.22 μ m filter membrane can be used for filtration. Meanwhile, PIPES can coexist with most salts, low concentration organic solvents (such as ethanol, DMSO), and biological reagents (enzymes, proteins) without worrying about stability conflicts. In summary, PIPES exhibits excellent chemical stability under conventional experimental conditions and is widely used in biological systems. As long as the storage and usage conditions are reasonably controlled, its buffering performance can be fully utilized, providing reliable guarantees for biological experiments. Since the establishment of Desheng, we have always adhered to the core values of "service first". For product after-sales, we have an elite after-sales team who not only meticulously track and follow up on customer feedback information, but also provide professional product technical guidance. In addition, we highly value every suggestion and opinion from our customers and actively adopt them to continuously optimize our services. Therefore, if you are looking for high-quality biological buffering agents, Desheng is undoubtedly your trusted choice, and we promise to do our best to meet your expectations.

The 92nd China International Medical Equipment Fair (CMEF) in 2025 will grandly kick off on September 26-29 at the China International Import and Export Fair in Guangzhou. As one of the most influential events in the global medical and health technology field, this year's CMEF is expected to gather thousands of enterprises from home and abroad to comprehensively showcase cutting-edge product technology and system solutions. Hubei Xindesheng Material Technology Co., Ltd. will showcase its full range of products at booth C06 in Hall 20.1, exploring the new future of diagnostic reagents with you! New Desheng's core product matrix launches a full-scale attack 1. High end biological buffer series Xindesheng has a complete range of biological buffer products, covering dozens of commonly used and customized types such as TRIS, HEPES, MOPS, etc., with a daily production capacity of up to 5 tons. The product has high purity and stable process, and can be widely used in fields such as molecular diagnosis, immune detection, cell culture, etc. It maintains the pH value of the reaction system and provides a solid guarantee for the reliability of experimental results. 2. IVD Diagnostic Core Raw Material Series Chromogenic substrate: It has high water solubility, high sensitivity, color stability, and wide system adaptability, supporting multiple color source selections and detection scenarios, significantly improving detection sensitivity and stability. Luminescent reagents: including luminol, isoluminol, and various functional acridine ester products, with high luminescence efficiency and fast reaction speed, meeting the diverse needs of chemiluminescence immunoassay. Enzyme preparations: covering high value-added projects such as cardiovascular, infectious disease, and tumor marker detection, with characteristics of high activity and high purity. 3. Blood collection reagent series As one of the earliest domestic enterprises to produce a complete set of blood collection tube additives, Xindesheng provides stable quality and complete product categories of blood collection tube reagents with mature technology and rich experience, and can also provide deep customization services to fully meet customers' personalized needs. Xin Desheng: Deeply cultivated for 20 years, trustworthy Hubei Xindesheng Material Technology Co., Ltd. was established in 2005. It is a national high-tech enterprise specializing in the research, development, production, and sales of blood test pre-processing reagents, in vitro diagnostic reagent raw materials, and biological buffering agents. The company adheres to the concept of "quality first, customer-oriented" and can provide professional customized development and large-scale production services. At present, Desheng is actively preparing for the construction of the new Huanggang factory. As of now, the main structure of Warehouse 3 has been successfully capped, and the construction of the gutter and roof system of Production Building 1 is proceeding efficiently. The new factory is committed to building a domestic base for high-end biological buffering agents, and the upgrading of production capacity is just around the corner. This will further consolidate Xindesheng's supply chain advantages and market competitiveness in the field of IVD raw materials. In person interaction, enjoy multiple benefits and values During the exhibition, Xindesheng sincerely invites you to visit booth C06 in Hall 20.1, participate in on-site interaction, and experience more exclusive benefits and opportunities for in-depth communication: 1. We not only provide you with a comfortable and cozy resting area and a variety of drinks and tea breaks, but also offer face-to-face communication with technical and marketing teams to obtain the latest product information and technical solutions, bringing new ideas and cooperation opportunities for your current project. 2. By visiting the booth for interaction, you can receive exquisite and practical gifts for free (including product samples, customized canvas bags, multifunctional USB drives, etc.). Each gift is designed to provide convenience for your daily research and development and work. 3. On site participation and interaction can also give priority to understanding the latest production line planning and customer exclusive support of Xindesheng, obtain more market trend interpretation and product customization resources, help reduce costs and increase efficiency, and seize market opportunities. Meet in Guangzhou and discuss the future together From September 26th to 29th, Hubei Xindesheng is looking forward to your visit at the C06 booth in Hall 20.1 of the China Import and Export Fair Complex (Pazhou Complex) in Guangzhou! We look forward to face-to-face communication with you on industry trends, sharing innovative achievements, and working together to promote the localization process of diagnostic reagent raw materials, creating new opportunities for cooperation. We are waiting for you in Guangzhou. See you soon!

Fluttering banners, embarking on a new journey, fighting fiercely for a hundred days to see the true chapter In the summer of 2025, on the hot land of innovation and entrepreneurship in Huanggang, Hubei, a modern chemical plant representing a new height in the industry is rising at an astonishing speed. Since the foundation laying and departure on July 18th, the Huanggang new factory project of Hubei Xindesheng Material Technology Co., Ltd. has embarked on a construction journey of racing against time with the spirit of "time waits for no one, seize the day and night". In just two months, the project team has written an impressive report card with wisdom and sweat, perfectly interpreting the profound connotation of "Desheng efficiency" with tangible construction results, injecting a shot in the arm for local economic development. Warehouse sealing: Warehouse center takes shape first On September 14, 2025, the project construction once again reached a milestone moment - the main structure of Warehouse 3 successfully completed the topping out work! This advanced design and fully functional storage facility has completed the main construction first, which means that the construction of the new factory has achieved significant results in this stage. The topping out of the warehouse not only creates conditions for subsequent internal decoration and equipment installation, but also ensures the efficient operation of the future factory logistics and warehousing system. At the topping out ceremony, the project leader stated, "The rapid topping out of Warehouse 3 is a testament to our careful organization and scientific construction, and also a good start for the on-time delivery of the entire project. Multi line joint promotion: Comprehensive construction momentum is unstoppable At the same time, the construction of other key nodes in the new factory area is also progressing efficiently and synchronously, presenting a busy scene of multiple blooming points and simultaneous progress. The construction of the gutter and roof system in the 1 # production plant is in full swing, creating favorable conditions for the installation of internal equipment in the plant; The circulating water tank supporting the factory area has completed the base treatment and entered the plastering construction stage, and the bottom plate formwork construction of the base water tank and the initial rainwater tank has also been fully carried out. The synchronous construction of these supporting facilities ensures the coordinated operation of production and environmental protection systems in the future factory area, reflecting New Desheng's high emphasis on sustainable development. Strategic positioning: Building a domestic base for high-end biological buffering agents The Huanggang New Factory project is committed to building a domestic high-end biological buffer production base, focusing on breakthroughs in key preparation technologies for a series of high-end biological buffers such as TRIS, HEPES, MOPS, etc. By constructing multiple intelligent production lines, the project will achieve a significant increase in the production of high-end biological buffering agents after it is put into operation, and it is expected that the annual output value will achieve a leapfrog growth. The construction of this base will effectively break the technological and market monopoly of foreign manufacturers in the field of high-end biological buffering agents. Anchor new goals and embark on a new journey The rapid progress of Huanggang's new factory construction is not only an important milestone in the development history of Xindesheng, but also a microcosm of China's intelligent manufacturing speed. From a blueprint to the initial scale of the factory building, from the groundbreaking ceremony to the topping out of the warehouse, the early completion of every milestone embodies the wisdom and sweat of all builders, demonstrating the corporate spirit of "pioneering innovation and pursuing excellence" of Xindesheng people. With the continuous advancement of the project, it will undoubtedly inject strong impetus into the future development of Xindesheng and contribute important strength to the high-quality development of the local economy.

For a long time, some studies have assumed that Bicine cannot interact with metal ions. However, an increasing number of facts indicate that Bicine can form stable binary or ternary complexes with metal ions, exhibiting certain chelating properties. The molecular structure of Bicine buffer is similar to that of glycine. This structure reduces the hydrolysis ability of the amino end, enhances overall stability, and also creates conditions for its binding with metal ions. Research has shown that Bicine can chelate with heavy metal ions such as copper (Cu), cadmium (Cd), and lead (Pb). However, this chelation effect is relatively weak and does not significantly interfere with the normal function of metal ions in most biochemical reactions, especially enzymatic reactions. In enzymatic reactions, metal ions often act as cofactors or coenzymes in the catalytic process, and their activity is highly influenced by various factors, with pH being one of the key factors. Extreme pH values can alter the binding state between metal ions and enzymes, thereby affecting catalytic activity. Bicine maintains pH stability in the solution while having weak chelation effect on metal ions, making it an ideal choice for enzymatic reactions that require the retention of metal ion activity. For example, in the serum guanine enzyme assay, the presence of Bicine can provide a stable pH environment for enzymatic reactions, and due to its weak binding properties with metal ions, it will not interfere with the role of metal ions in the reaction, ensuring the accuracy of the measurement results. From an application perspective, this characteristic of Bicine enables it to be widely used in many fields. In protein crystallization solution, Bicine can maintain the pH stability of the system without affecting the necessary interactions between proteins and metal ions due to excessive chelation of metal ions, which is beneficial for the growth and stability of protein crystals. Bicine acts as a buffer when extracting enzymes from various plant species, ensuring a suitable pH environment and maintaining metal ions in a free state that can participate in the composition of enzyme active centers or promote enzyme activity. In polymerase chain reaction (PCR), Bicine buffer system provides stable acid-base conditions for the reaction, while not hindering the reaction due to strong chelation of metal ions (such as magnesium ions, activators of Taq DNA polymerase in PCR reaction). Overall, the weak binding properties of the biological buffer Bicine with metal ions have more advantages than disadvantages in most biochemical and molecular biology applications. It provides a stable and suitable environment for numerous biochemical reactions that require the participation of metal ions, ensuring the authenticity and reliability of experimental results. With the continuous deepening of research and the expansion of application fields, fully understanding and reasonably utilizing the characteristics of Bicine and metal ions will inject new vitality into the development of related fields. The Bicine buffer produced by Hubei Xindesheng Material Technology Co., Ltd. has a low chloride ion content and all indicators meet relevant standards. In addition to Bicine buffer, Desheng actively researches and develops dozens of biological buffers such as TRIS and Hepes commonly used in the market. If you are interested, please click on the Desheng official website to learn more details! Overall, the weak binding properties of the biological buffer Bicine with metal ions have more advantages than disadvantages in most biochemical and molecular biology applications. It provides a stable and suitable environment for numerous biochemical reactions that require the participation of metal ions, ensuring the authenticity and reliability of experimental results. With the continuous deepening of research and the expansion of application fields, fully understanding and reasonably utilizing the characteristics of Bicine and metal ions will inject new vitality into the development of related fields. The Bicine buffer produced by Hubei Xindesheng Material Technology Co., Ltd. has a low chloride ion content and all indicators meet relevant standards. In addition to Bicine buffer, Desheng actively researches and develops dozens of biological buffers such as TRIS and Hepes commonly used in the market. If you are interested, please click on the Desheng official website to learn more details!  

Currently, China's primary healthcare system is undergoing unprecedented transformation and upgrading, leading to explosive growth in the field of in vitro diagnostics (IVD). This trend was confirmed at the recent "Million Talents Gathering in Southern Guangdong" medical and health job fair: 334 employers offered more than 6500 positions, with a particularly prominent demand for professionals in imaging, anesthesia, and other fields in county-level medical institutions. It is worth noting that the development of these departments is closely related to IVD technology, reflecting the strong demand for diagnostic testing in primary healthcare. The deep driving force behind the surge in demand The sustained release of policy dividends is the primary driving force. With the support of national policies, the hardware facilities of grassroots medical institutions have been comprehensively upgraded, and modern diagnostic and treatment equipment has been installed in township health centers and village clinics. Hardware improvements have created conditions for carrying out diversified testing projects, while the demand for accurate diagnosis among grassroots doctors has also skyrocketed. The rapid detection technology represented by POCT can precisely meet the dual pursuit of timeliness and accuracy at the grassroots level. The demographic changes bring new challenges. Global data show that the incidence rate of invasive fungal disease is increasing at an annual rate of 0.9%, and the elderly, especially those with chronic diseases, become vulnerable. The early identification of such diseases at the grassroots level highly relies on IVD technologies such as fungal culture and G-testing, which requires primary healthcare institutions to enhance their diagnostic capabilities. The deepening implementation of the hierarchical diagnosis and treatment system reshapes the pattern of medical treatment. With the promotion of the policy of first diagnosis at the grassroots level, grassroots medical institutions need to establish a more comprehensive diagnostic system. Fast and reliable IVD testing can not only help doctors timely assess the condition, but also provide scientific basis for patient referrals, effectively improving the efficiency of medical resource utilization. The deep driving force behind the surge in demand The sustained release of policy dividends is the primary driving force. With the support of national policies, the hardware facilities of grassroots medical institutions have been comprehensively upgraded, and modern diagnostic and treatment equipment has been installed in township health centers and village clinics. Hardware improvements have created conditions for carrying out diversified testing projects, while the demand for accurate diagnosis among grassroots doctors has also skyrocketed. The rapid detection technology represented by POCT can precisely meet the dual pursuit of timeliness and accuracy at the grassroots level. The demographic changes bring new challenges. Global data show that the incidence rate of invasive fungal disease is increasing at an annual rate of 0.9%, and the elderly, especially those with chronic diseases, become vulnerable. The early identification of such diseases at the grassroots level highly relies on IVD technologies such as fungal culture and G-testing, which requires primary healthcare institutions to enhance their diagnostic capabilities. The deepening implementation of the hierarchical diagnosis and treatment system reshapes the pattern of medical treatment. With the promotion of the policy of first diagnosis at the grassroots level, grassroots medical institutions need to establish a more comprehensive diagnostic system. Fast and reliable IVD testing can not only help doctors timely assess the condition, but also provide scientific basis for patient referrals, effectively improving the efficiency of medical resource utilization. Future Prospects Despite challenges such as talent shortage and quality control, the grassroots IVD market has enormous potential driven by policy support and technological progress. It is expected that in the coming years, with the integration and application of new technologies such as telemedicine and artificial intelligence, grassroots diagnostic services will develop towards a more intelligent and accurate direction, providing strong support for the construction of a healthy China. After years of development, Hubei Xindesheng Material Technology will uphold innovative concepts, continuously improve product quality and service levels, and contribute to the development of the IVD industry.  

Acridine esters, as an important class of chemiluminescent reagents, are widely used in fields such as immunoassay, nucleic acid detection, and biosensors due to their high sensitivity, rapid luminescence, and low background interference. However, its unique chemical properties require strict adherence to specific specifications during the dissolution process, otherwise it may lead to reagent deactivation or experimental failure. This article will start from the preservation characteristics of acridine esters and systematically analyze their scientific dissolution methods and operational points. Preservation characteristics of acridine ester: necessity of freeze-dried powder and low-temperature light avoidance Acridine esters are typically provided in the form of freeze-dried powder, which is designed to inhibit hydrolysis reactions and prolong reagent stability by removing moisture. The freeze-drying process can remove over 95% of the moisture, keeping the acridine ester molecules in an inactive state while avoiding aggregation or degradation caused by the presence of moisture. In addition, low temperature (usually -20 ℃ or lower) and light avoidance conditions are key to preserving acridine esters: low temperature can slow down molecular thermal motion and reduce hydrolysis rate; Avoiding light can prevent structural damage caused by photosensitive reactions. For example, acridine esters containing NHS (N-hydroxysuccinimide) groups are highly sensitive to both light and moisture, and exposure to room temperature or light for several hours can result in a loss of activity of over 50%. Selection of dissolution medium: necessity of non protonated solvents The dissolution of acridine esters requires avoidance of aqueous solutions, which is based on the unique chemical structure. The ester bonds and NHS groups in acridine ester molecules are highly susceptible to nucleophilic attack reactions with water molecules, leading to hydrolysis cleavage. Especially for acridine esters containing NHS groups, their hydrolysis half-life is only a few minutes to a few hours in water, but can be extended to several days or even weeks in non protonated solvents. Therefore, the following two types of solvents should be used to dissolve acridine esters: 1. Polar non proton solvents: such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), which have no active hydrogen in their molecules and cannot provide protons to participate in hydrolysis reactions. At the same time, they can effectively dissolve the hydrophobic acridine ring structure of acridine esters. DMSO has become the most commonly used choice in laboratories due to its low toxicity, high boiling point (189 ℃), and good biocompatibility; DMF is suitable for the preparation of high concentration acridine esters due to its stronger solubility. 2. Mixed solvent system: For extremely insoluble acridine ester derivatives, a mixed solvent of DMSO and acetonitrile (ACN) or dimethylacetamide (DMA) can be used to promote dissolution by adjusting polarity. For example, mixing DMSO and ACN in a volume ratio of 7:3 can reduce the viscosity of the solution while maintaining its non protonated properties, making it easier for subsequent operations. Adaptation of application scenarios: from labeling reaction to luminescence detection The dissolved acridine ester solution can be directly used for chemiluminescence labeling of proteins, antibodies, or nucleic acids. For example, in immunoassays, acridine ester antibody conjugates can bind to antigens in aqueous buffer and subsequently trigger chemiluminescence reactions by adding hydrogen peroxide and sodium hydroxide. It is worth noting that the labeling reaction requires strict control of pH (usually 7.2-7.6) and ionic strength to avoid affecting the luminescence efficiency of acridine esters. Conclusion The dissolution of acridine ester is a key link connecting its stable storage and efficient application. By selecting non protonated solvents, standardizing operating procedures, and adapting to application scenarios, the chemiluminescence potential of acridine esters can be fully released, providing a highly sensitive and specific solution for biological detection. In the future, with the development of new anti hydrolysis acridine ester derivatives, their dissolution and application conditions are expected to be further optimized, promoting breakthroughs in chemiluminescence technology in more fields. As a manufacturer of luminescent reagents, Desheng is currently fully committed to supplying a range of high-quality acridine ester powders. These products are not only convenient to use, but also known for their luminescence sensitivity, ensuring that you can obtain accurate and reliable experimental results in a very short period of time. If you have purchasing needs or would like to learn more details, please feel free to click on our official website for consultation.  

Free Fatty Acids (FFA), as the core intermediate product of human energy metabolism, its abnormal level is closely related to diabetes, obesity, cardiovascular disease and metabolic syndrome. Accurately and rapidly measuring FFA concentration is not only a key indicator for clinical diagnosis, but also an important tool for drug development and nutritional assessment. Among numerous detection methods, the colorimetric substrate TOPS enzyme photometric method has gradually become the mainstream technology for FFA determination due to its high sensitivity, strong stability, and convenient operation. Technical principle: Perfect combination of enzymatic reaction and colorimetric reaction The core of TOPS enzymatic photometry is to link the enzymatic oxidation process of FFA with colorimetric reaction, and quantitatively analyze it through colorimetric method. Specifically, the detection process is divided into two steps: 1. Enzymatic oxidation stage: FFA in the sample is catalyzed by acetyl CoA synthase to bind with ATP and CoA to generate acetyl CoA, while releasing pyrophosphate; Subsequently, acetyl CoA oxidase further oxidizes acetyl CoA to produce hydrogen peroxide (H ₂ O ₂). 2. Color reaction stage: Under the catalysis of peroxidase (HRP), H ₂ O ₂ undergoes redox reaction with the color substrate TOPS and 4-aminoantipyrine (4-AAP) to generate stable red quinone imine compounds. The color depth of the compound is linearly related to the concentration of FFA, and the FFA content can be accurately calculated by measuring the absorbance with a spectrophotometer (usually at a wavelength of 550-570nm). Technical advantages: sensitive, stable, easy to operate Compared with traditional methods, TOPS enzyme photometry exhibits significant advantages: 1. High sensitivity: TOPS has a much higher molar absorptivity than traditional color reagents (such as copper reagents), and can detect FFA as low as μ mol/L. It is particularly suitable for precise analysis of low concentration samples such as serum. 2. Strong stability: TOPS has stable chemical properties and is not easily affected by temperature, pH fluctuations, or sample matrix interference, ensuring the repeatability and reliability of detection results. In addition, the kit format (dual reagent system) further simplifies the operation process and reduces human errors. 3. Convenient operation: No complex preprocessing steps (such as organic extraction or derivatization) are required. The sample can be directly mixed and incubated with the reagent, and the detection can be completed in 10-15 minutes, greatly reducing the detection time. 4. High cost-effectiveness: Compared with gas chromatography or liquid chromatography, TOPS enzyme photometry does not require expensive instruments and equipment, has low reagent consumption, and is suitable for large-scale promotion in clinical laboratories. Clinical Application: From Disease Diagnosis to Health Management The application scenarios of TOPS enzyme photometry are extensive, covering multiple fields such as clinical diagnosis, metabolic research, and drug development 1. Cardiovascular disease risk assessment: The increase of FFA level is an independent risk factor for atherosclerosis and myocardial ischemia. Regular detection can assist in early diagnosis and prognosis monitoring. 2. Metabolic disease management: diabetes patients are often accompanied by FFA metabolic disorder. Dynamic monitoring of FFA concentration can optimize insulin treatment programs and control blood sugar fluctuations. Conclusion: The TOPS enzyme photometry method, based on innovative scientific principles and practical technical implementation, provides an efficient and accurate solution for FFA detection. From clinical diagnosis to health management, from basic research to drug development, this technology is continuously driving the progress of metabolic medicine and safeguarding human health. The TOPS and other the new Trinder's reagents produced by Hubei Xindesheng Material Technology Co., Ltd. have high purity, good water solubility, stable production process, and small inter batch differences. All indicators meet relevant standards. If you have any purchasing needs in the near future, please feel free to contact me or click on the official website for more details!  

In biological and biochemical experiments, biological buffering agents serve as the core reagent for maintaining solution pH stability, and their sterilization treatment directly affects the accuracy and reliability of experimental results. From cell culture to protein purification, from nucleic acid research to drug development, the sterilization decision of buffer solution needs to be comprehensively judged based on experimental type, reagent characteristics, and operating standards. The necessity of sterilization: the type of experiment determines the risk level 1. Rigid requirements for high-sensitivity experiments In experiments such as cell culture, gene editing, or single-molecule testing that require high levels of sterility, microbial contamination may lead to cell death, abnormal gene expression, or signal interference. For example, although MOPS buffer is commonly used for RNA electrophoresis, its pH stability is easily affected by microbial metabolites. If the experiment involves rare samples or long-term cultivation, high-pressure sterilization can effectively eliminate potential sources of contamination. Similarly, after high-pressure sterilization, the pH stability of BES buffer solution is significantly improved, making it suitable for cell experiments sensitive to ion strength. 2. Stability guarantee for long-term storage Unterilized buffer solutions may breed microorganisms during storage, leading to pH drift or precipitation. For example, phosphate containing buffer solutions are prone to form insoluble complexes with calcium and magnesium ions at high temperatures, and sterilization treatment can delay this process. For Tris HCl buffer solutions that require long-term storage, high-temperature and high-pressure sterilization can ensure their chemical stability and avoid degradation of active ingredients caused by microbial growth. 3. Avoid external protein interference The proteins contained in microorganisms themselves may interfere with experimental results through cross reactions. In Western Blot experiments, if the buffer is not sterilized, bacterial proteins may undergo non-specific binding with the target protein, leading to false positive signals. Sterilization treatment can completely remove such interference sources, especially suitable for low abundance protein detection or high specificity antibody incubation scenarios. Practical considerations for sterilization: balancing cost and benefit 1. Experimental cost and operational complexity High pressure sterilization requires specialized equipment and takes a long time, while membrane filtration, although fast, requires regular replacement of the membrane. For large-scale experiments, membrane filtration may increase the cost of consumables; For small-scale or high-value experiments, the benefits of sterile assurance far exceed the costs. For example, in the production of gene therapy vectors, the use of sterilization buffer can avoid batch contamination risks and ensure product safety. 2. Supplementary role of operating standards Even if the buffer has been sterilized, sterile operating procedures must still be followed throughout the experiment. For example, using sterile pipette tips during the transfer process and operating in ultra clean workbenches can further reduce the risk of contamination. In addition, experimenters wearing lab coats, gloves, and goggles can avoid secondary contamination of the buffer solution by human microorganisms. Conclusion: Scientific decision-making and precise sterilization The sterilization treatment of biological buffering agents is not a one size fits all approach, but requires comprehensive decision-making based on the type of experiment, reagent characteristics, and operating conditions. Sterilization is a necessary means to ensure the reliability of results for high-sensitivity experiments, long-term storage, or scenarios involving external protein interference; For routine experiments or thermosensitive buffering agents, membrane filtration or strict aseptic operation can replace high-pressure sterilization. By scientifically selecting sterilization methods and standardizing operating procedures, the performance of biological buffering agents can be maximized, providing solid support for biological research. Hubei Xindesheng Material Technology Co., Ltd. is a manufacturer of diagnostic reagent raw materials, which can provide various biological buffering agents, including Tris, Tris HCl, Bis Tris, Bicine, TAPS and other reagents. If you need to purchase, please feel free to contact us at any time!  

On the morning of September 3, 2025, Hubei Xindesheng Material Technology Co., Ltd. organized all employees to watch the live broadcast of the grand September 3 military parade, witnessing the magnificent strength of the country and feeling the spirit of the times together. The activity aims to deepen patriotic education, enhance team cohesion, and inspire employees' sense of national pride and professional mission.   At 9 o'clock in the morning, the company conference room was filled with a solemn and enthusiastic atmosphere. All employees hold bright red flags issued by the company and watch the parade on the big screen with focused expressions. When the imposing troops marched with resolute steps, when advanced weapons and equipment appeared one by one, and when the fighter jets soaring in the blue sky traced magnificent paths, sincere admiration and warm applause erupted from the scene time and time again. The employees waved the red flag in their hands, sincerely feeling proud and honored for the increasingly strong comprehensive national strength and glorious achievements in national defense construction of the motherland.   Chairman Wang Zhongxi passionately elaborated on the profound enlightenment brought by watching the military parade in his speech. He first mentioned emotionally that the resolute figure of all the soldiers who stood still for hours in the scorching heat is a reflection of the precious craftsmanship spirit of this era. Behind this perseverance is the noble choice of integrating personal values into the destiny of the country. The people of Xindesheng should also cherish their country and closely link their personal growth with the development of enterprises and the country. Mr. Wang also pointed out that the grand military parade demonstrated the prosperity and stability of the country, which is the solid foundation for enterprises to operate with peace of mind and continue to develop. New Desheng must integrate its own development into the overall development of the country and repay the opportunities given by the times with practical actions.   Chairman Wang Zhongxi called on all employees of Xindesheng to transform the surging enthusiasm and deep patriotism inspired by watching the military parade into practical actions that are down-to-earth. He demands that everyone deeply study and understand the spirit of the military parade, which embodies perseverance, loyalty, collaboration, and responsibility, and inject it into every research and development project, every production process, and every market service. With a more vigorous fighting spirit and an attitude of striving for excellence, we are committed to innovation and breakthroughs in the field of IVD. With outstanding work performance and continuously rising corporate achievements, we contribute our wisdom and strength to the prosperity of the local economy and the technological progress of the industry. We turn this ambitious mission of serving the country into a sincere and moving gift to our great motherland.   Hubei Xindesheng is currently in a new stage of rapid development. The construction of a new production base in Huanggang has entered an accelerated stage, aiming to create a production base for high-end biological buffering agents in China, in order to break through import dependence and achieve domestic substitution of key raw materials. We firmly believe that Hubei Xindesheng will transform the pride and sense of mission inspired by the military parade into an inexhaustible driving force for promoting the independent and controllable development of the IVD industry chain with high quality. With higher quality innovative products and outstanding industry contributions, we will serve our ancestors