China Wuhan Desheng Biochemical Technology Co., Ltd Company News

In biochemical and molecular biology experiments, the ionic strength of a solution is a crucial parameter that directly affects the stability, activity, and interactions of biomolecules. In order to maintain stable experimental conditions, scientists often rely on biological buffering agents to adjust the pH and ionic strength of the solution. Among them, N, N-bis (2-hydroxyethyl) -2-aminoethanesulfonic acid (BES), as an efficient biological buffer, plays a crucial role in this field due to its excellent buffering capacity and stability. Basic properties and applications of BES BES, It is a white crystalline powder that exists stably at room temperature and pressure. As an ideal biological buffer, it is suitable for various biochemical experiments and pharmaceutical synthesis processes. BES has a wide range of applications, including but not limited to cell culture, enzymatic reactions, protein crystallization, drug development, biosensors, and chromatographic technology. During the cell culture process, BES can stabilize the pH value of the culture medium, providing a more suitable growth environment for cells, thereby improving their survival rate and proliferation efficiency. In enzymatic reactions, the buffering effect of BES can maintain the pH stability of the reaction system, ensuring that the enzyme functions at its optimal activity state and improving the efficiency and accuracy of enzymatic reactions. In addition, BES has also demonstrated its unique application value in fields such as protein crystallization, drug development, and biosensors. The importance of adjusting ion strength Ionic strength is a measure of the concentration of ions in a solution and is a function of the concentration of all ions in the solution. When ionic compounds dissolve in water, they dissociate into ions, and the concentration and charge of these ions together determine the ionic strength of the solution. The magnitude of ionic strength directly affects the behavior and properties of biomolecules in solution. For example, ionic strength can affect the solubility, stability, conformational changes, and interactions with other molecules of proteins. In biochemical experiments, in order to obtain accurate and reproducible experimental results, it is necessary to strictly control the ionic strength of the solution. BES, as a zwitterionic buffer, has excellent buffering performance and biocompatibility, and can effectively absorb or release protons (H+) in a wide pH range, thereby maintaining the relative stability of solution pH. Meanwhile, by adjusting the concentration of BES, the ionic strength of the solution can be controlled, thereby affecting the behavior and properties of biomolecules. Application examples of BES in regulating ion strength In cation exchange chromatography, BES is used as a binding buffer and eluent, which can adjust the pH and ionic strength of the solution, affecting the binding and elution process of biomolecules with the chromatographic column. By adjusting parameters such as BES concentration, pH value, and ionic strength, the separation efficiency of cation exchange chromatography can be optimized. For example, increasing the concentration of BES can enhance the ionic strength of the solution and strengthen the binding force between biomolecules and the chromatographic column; Lowering the pH value can make biomolecules carry more positive charges and increase their affinity for cation exchange chromatography columns. In gel filtration chromatography, BES also plays an important role as a buffer. It can maintain the stability of the pH value of the solution, ensuring the stability and activity of biomolecules during the separation process. Meanwhile, by adjusting the concentration of BES, the ion strength of the solution can be controlled, thereby affecting the elution speed and separation efficiency of proteins. Appropriate ionic strength can enhance the interaction between protein and gel particles, extend the elution time of protein, and improve the separation efficiency. In addition, in protein crystallization research, BES as a buffer can adjust the pH and ionic strength of the solution, providing a suitable crystallization environment for protein molecules. High quality crystals not only help reveal the three-dimensional structure of proteins, but also provide important structural information for drug development. Conclusion In summary, the biological buffer BES plays a crucial role in regulating the ionic strength of solutions. Its excellent buffering performance and stability make BES an indispensable reagent in biochemical experiments. By precisely regulating the concentration of BES and the pH value of the solution, the process and results of various biochemical experiments can be optimized. In the future, with the development of biotechnology and structural biology, the potential of BES in regulating solution ion strength and promoting the research and application of biomolecules will be further explored and utilized. As a BES buffer raw material manufacturer, Desheng has advanced production technology and strict quality management system. The BES raw materials produced have high purity and stable quality, which can meet customers' demand for high-quality products. At the same time, Desheng focuses on technological innovation and research and development, continuously optimizing production processes,

Against the backdrop of the booming global healthcare market, the demand for medical consumables raw materials continues to rise. For global buyers, it is crucial to find a supplier that can provide high-quality and comprehensive medical consumables raw material solutions. Hubei Xindesheng Material Technology Co., Ltd., as a leader in the industry, will appear at the 2025 Türkiye International Medical Device Exhibition, bringing unprecedented cooperation opportunities to global buyers. 1, Enrich product line to meet diverse needs Hubei Xindesheng Material Technology Co., Ltd. has been deeply involved in the field of medical consumables raw materials for many years, and has built a rich and complete product line. The company focuses on the research and production of in vitro diagnostic reagents, mainly including biological buffering agents, chemiluminescence reagents, chromogenic substrates, and a full range of blood collection tube additives. These products have rich research and development experience and mature production lines. Professional technicians and advanced equipment can provide customized services and technical support. In addition, in the past two years, the company has focused on the research and development of diagnostic enzymes and established a professional technical team. Currently, pyruvate kinase, cholesterol oxidase, uricase, adenosine deaminase, S-adenosyl-homocysteine hydrolase, and other enzymes have been successfully launched on the market. At the same time, the company is actively preparing for the construction of a new factory, expanding production lines, improving production capacity while reducing costs, and providing high-quality in vitro diagnostic products for its customers. 2, Excellent quality, forging industry reputation Quality is the lifeline of an enterprise, and Hubei Xindesheng Material Technology Co., Ltd. is well aware of this. The company strictly controls every aspect of raw material procurement, production and processing, quality inspection, etc., to ensure that products meet international standards and customer requirements. With excellent quality, the company's products not only occupy an important share in the domestic market, but also are exported overseas, serving the health and medical industry of people in various countries, and winning high recognition and good reputation from customers. Many well-known domestic and foreign medical device companies have established long-term and stable cooperative relationships with Xindesheng, which undoubtedly proves the best quality of the company. 3, Türkiye Exhibition Opens a New Chapter of Cooperation From April 24 to 26, 2025, the 32nd Türkiye International Medical Device Exhibition will be held in Istanbul TUYAP International Exhibition Center. As the largest medical exhibition in Eurasia, this exhibition attracts hundreds of exhibitors and tens of thousands of visitors every year. It is a leading exhibition of medical trade in Türkiye and Eurasia. Hubei Xindesheng Material Technology Co., Ltd. will showcase its one-stop medical consumables raw material solutions in all aspects at this exhibition, and have face-to-face exchanges with global buyers. In order to thank global buyers for their support and trust, the company has specially launched an exclusive offer for signing contracts at the exhibition site. Buyers who sign contracts with Xindesheng at the exhibition site will enjoy exclusive benefits such as price discounts, priority supply, and customized services. This is not only an opportunity for business cooperation, but also an opportunity to work together and create a better future. In today's rapidly developing global healthcare market, choosing a reliable supplier of medical consumables raw materials is the key to the success of buyers. Hubei Xindesheng Material Technology Co., Ltd. will become an ideal partner for global buyers with its rich product line, excellent quality, and exclusive treatment at the exhibition site. The 2025 Türkiye International Medical Device Exhibition looks forward to meeting with you to open a new chapter of cooperation in medical consumables!

Biological buffering agents play a crucial role in biochemical and molecular biology research. They can stabilize the pH value of the solution, providing an ideal environment for experimental processes such as enzymatic reactions, protein crystallization, DNA/RNA manipulation, etc. Bicine, as a common biological buffering agent, is highly favored due to its excellent buffering capacity and low interference with biomolecules. However, the chloride ion content, as an important indicator of Bicine buffer, has a significant impact on its performance and application effectiveness. The adverse effects of chloride ions on experiments Chloride ions, as a common anion, may bring some adverse effects in biochemical experiments. Firstly, high concentrations of chloride ions may cause non-specific reactions with other ions or molecules in the experiment, leading to deviations in the experimental results. Secondly, chloride ions may interfere with the conformation and stability of proteins, thereby affecting their function and activity. In addition, chloride ions may also affect the activity and stability of enzymes, thereby affecting the efficiency and accuracy of enzyme catalyzed reactions. The influence of chloride ion content on the performance of Bicine buffer 1. Maintain experimental stability The main function of Bicine buffer is to maintain pH stability during the experimental process. Strict control of chloride ion content can help achieve this goal. High chloride ion content may lead to unstable pH values, thereby affecting the accuracy of experiments. In contrast, Bicine buffer with low chloride ion content can more stably maintain the pH value of the solution, ensure the consistency of experimental conditions, and improve the stability and reliability of the experiment. 2. Improve experimental accuracy In experiments that require high-precision measurements, such as protein crystallization and enzyme activity assays, the presence of chloride ions may become a potential interfering factor. Bicine buffer with low chloride ion content can reduce this interference, avoid unnecessary experimental errors, and improve the accuracy of experimental results. 3. Protecting cellular health In cell biology experiments, the health status of cells directly affects the quality of experimental results. Buffer solutions with high chloride ion content may have toxic effects on cells, affecting their growth and function. Bicine buffer with low chloride ion content can effectively maintain the healthy state of cells, provide a good growth environment for cells, and ensure the reliability of experimental results. How to control the chloride ion content in Bicine buffer 1. Optimize raw material selection The chloride ions in Bicine buffer mainly come from the raw materials and preparation process. Therefore, in the selection of raw materials, low chloride ion raw materials should be chosen as much as possible to reduce the residual chloride ions in the finished product. 2. Improve the preparation process During the preparation process, the reagents, water sources, and other substances that may contain chloride ions should be strictly controlled. By improving the preparation process, such as using high-purity water sources, reagents, and more precise purification steps, the chloride ion content in Bicine buffer can be effectively reduced. 3. Strengthen quality inspection Strict quality testing of the finished Bicine buffer is crucial to ensure that its chloride ion content meets the standard. By using advanced analytical techniques such as high-performance liquid chromatography (HPLC), the chloride ion content in Bicine buffer can be accurately determined, and the preparation process can be adjusted in a timely manner to ensure product quality. Conclusion The chloride ion content, as an important indicator of Bicine buffer, has a significant impact on its performance and application effectiveness. By strictly controlling the chloride ion content, it is possible to maintain pH stability during the experimental process, improve experimental accuracy, protect cell health, and extend storage life. Therefore, in the preparation and application of Bicine buffer, full attention should be paid to the control of chloride ion content to ensure its optimal performance and application effect. In summary, the influence of chloride ion content on the biological buffer Bicine cannot be ignored. In future research and applications, we need to continue exploring more effective methods for controlling chloride ion content to further improve the performance and application value of Bicine buffer. The chloride ion content of bicine buffer produced by Hubei Xindesheng Material Technology Co., Ltd. is less than 0.1%, and all indicators meet relevant standards. In addition to bicine buffer, Desheng actively researches and develops dozens of biological buffers such as TRIS and hepes commonly used in the market. If you are interested, please click on the Desheng official website to learn more details!

In the spring of April 2025, Expomed Eurasia, a grand event attracting the attention of the global medical industry, will soon open in Istanbul. As a leader in the field of in vitro diagnostics (IVD) raw materials, Desheng New Materials will showcase its innovative product lineup at this exhibition (booth number: 829C5), aiming to exchange experiences and negotiate cooperation with global peers, and jointly promote the vigorous development of the medical industry. Türkiye Medical Exhibition: a bright stage for global medical industry exchange Expomed Türkiye Medical Exhibition is a very influential medical industry event in Europe, the Middle East and North Africa. This exhibition not only brings together medical equipment manufacturers, raw material suppliers, medical technology service providers, etc. from around the world, but also attracts the attention of numerous medical institutions, industry associations, and professionals. The exhibition will be held in Istanbul from April 24 to 26, 2025. This city with unique geographical location is not only the economic and cultural center of Türkiye, but also an important hub connecting the East and the West. During the exhibition, Desheng New Materials will fully utilize this platform to showcase its innovative technologies and products, and collaborate with colleagues in the global medical industry to create a new chapter in industry development. Desheng New Materials: Leading Industry Development with Technological Innovation From 2005 to 2025, Desheng New Materials has written a history of progress in China's IVD raw materials in twenty years. The company is based in Ezhou, Hubei and has a production base covering an area of 5000 square meters. It has a professional R&D team of 30 people, with over 80% of them holding doctoral and master's degrees. It is precisely this persistence that has enabled Desheng to grow from a start-up enterprise to a high-tech enterprise with a complete industrial chain. Desheng New Materials always adheres to the concept of "craftsmanship, quality, innovation driven", and is committed to providing customers with high-performance, low-cost, and domestically produced core raw materials. After 20 years of technological accumulation and market refinement, the company has developed into a high-tech enterprise that integrates research and development, production, sales, and service throughout the entire industry chain. Five core product series unveiled at the exhibition site At this exhibition, Desheng New Materials will showcase its five core product lines, including chemiluminescence series, biological buffer series, chromogenic substrate series, enzyme preparations, and antigen antibodies. These products are widely used in fields such as biochemical analysis, immune testing, molecular diagnostics, etc., providing stable and reliable raw material support for global customers. Chemiluminescence series: providing highly sensitive chemiluminescence immunoassay core materials, suitable for high-precision requirements such as tumor markers and infectious diseases. Biological buffer series: purity over 99.9%, batch difference less than 1%, widely used in PCR, gene sequencing, cell culture and other fields. Color substrate series: fast color development speed, low background value, supports customized formulas, and meets the needs of fully automatic biochemical analyzers and POCT equipment. Enzyme preparations: high activity, high purity, and stability, covering various testing items such as cardiovascular markers, infectious disease screening, tumor diagnosis, etc. Antigen antibody: There are up to a hundred types of products with high specificity and sensitivity, which can be used in fields such as immunology research, protein research, and disease diagnosis. Seeking common development and jointly creating the future On the stage of Türkiye Medical Exhibition Expomed Eurasia, Desheng New Materials looks forward to in-depth exchanges with colleagues in the global medical industry, to jointly discuss the development trend of the industry, and to share technological innovation achievements. We sincerely invite all allies to visit our booth (829C5) to explore the future of medical technology and work together to create a better tomorrow.  

Chloroplasts, the green energy factories in plant cells, are the main site of photosynthesis. Within chloroplasts, a series of complex biochemical reactions convert light energy into chemical energy, providing a continuous source of power for plant growth and development. Among them, electron transfer, as one of the key steps in photosynthesis, involves the participation of multiple electron transfer chains and enzymes, and its process is extremely sensitive to environmental conditions. In order to ensure the accuracy and reliability of electron transfer studies in chloroplast thin layer sample preparation, the application of biological buffer TAPS buffer (N-tris (hydroxymethyl) methyl-3-aminopropanesulfonic acid) is particularly important. 1, TAPS maintains pH stability in chloroplast thin layer sample preparation TAPS, As a zwitterionic buffer, it is widely favored in biochemical research due to its unique chemical properties and biocompatibility. The amino and sulfonic acid groups in its molecular structure enable TAPS to provide stable buffering effects in the neutral to alkaline range, effectively resisting external environmental interference on pH values. Maintaining a stable pH value is crucial for ensuring smooth electron transfer during the preparation of chloroplast thin layer samples. Because even small fluctuations in pH can affect the conformation and activity of enzymes in the electron transport chain, thereby affecting the efficiency and direction of photosynthesis as a whole. The addition of TAPS is like a fine regulator that ensures that the pH value of the reaction system remains within the most suitable range, providing a stable and favorable environment for electron transfer. 2, TAPS protects protein structure and function in chloroplasts In addition to maintaining pH stability, TAPS also has a significant protective effect on proteins in chloroplasts. During the preparation of chloroplast thin layer samples, the structure and function of proteins are highly susceptible to external factors, which can cause changes and even lead to inactivation. The biocompatibility of TAPS ensures that it does not have any adverse effects on proteins in chloroplasts, but rather can stabilize the structure of proteins to a certain extent and maintain their functional integrity. This is crucial for subsequent research on electron transfer, as the integrity and function of proteins are the foundation for smooth electron transfer. 3, TAPS improves the separation efficiency of chloroplast thin layer samples TAPS also plays an irreplaceable role in improving the separation efficiency of chloroplast thin layer samples. The isolation of chloroplasts is a fundamental technique in chloroplast research, and its purity and integrity directly affect the results of subsequent experiments. The addition of TAPS can effectively reduce ion exchange and the binding of proteins and impurities, improving the purity and integrity of chloroplast separation. This enables researchers to obtain chloroplast samples more accurately, providing reliable experimental materials for subsequent studies such as electron transfer. 4, TAPS regulates the ionic strength of the reaction system to promote electron transfer In addition, TAPS also affects the rate and efficiency of electron transfer by adjusting the ionic strength of the reaction system. Ionic strength is one of the important factors affecting enzyme catalyzed reactions, and an appropriate ionic strength can promote electron transfer reactions and improve the efficiency of photosynthesis. As an excellent buffering agent, TAPS can precisely adjust the ion strength of the reaction system to maintain it within the most suitable range, thereby ensuring smooth electron transfer. In summary, TAPS plays a central role in the study of electron transfer in chloroplast thin layer sample preparation. It can not only maintain a stable reaction environment, protect the structure and function of proteins, improve separation efficiency, but also regulate the ion strength of the reaction system and promote smooth electron transfer. Meanwhile, TAPS also has broad application prospects in other research fields of chloroplasts. With the deepening and expansion of TAPS research, we believe that its application in chloroplast research will become more extensive and in-depth, opening a new chapter in the study of photosynthesis and functional analysis of chloroplasts. Hubei Xindesheng Material Technology, as a manufacturer of biological buffering agents, has rich experience in research and development and production. Currently, there are dozens of biological buffering agents on sale, with excellent product performance and affordable prices. Businesses in need can click on Desheng's official website for inquiries!

In biochemical experiments, biological buffering agents play a crucial role. They can maintain pH stability in the experimental system, ensuring that biomolecules such as enzymes and proteins maintain their activity and function. Among them, BES buffer, as an excellent biological buffering agent, has been widely used in the field of biochemistry due to its good water solubility, chemical stability, and wide pH buffering range. However, it is worth noting that when the concentration of BES is too high, it may inhibit enzyme activity, thereby affecting the accuracy and reliability of experimental results. This article will delve into the causes, impacts, and precautions to be taken when using BES buffer. Basic characteristics of BES buffer BES is an important Good's buffer with excellent buffering capacity and chemical stability. This means that within this range, BES also has good biocompatibility, with minimal impact on cells and tissues, making it suitable for the field of biomedicine. These characteristics make BES an ideal choice for studying the activity of biomolecules, enzymatic reactions, and cell culture experiments. The effect of high BES concentration on enzyme activity Enzymes are a class of biomolecules with catalytic functions that can accelerate the rate of chemical reactions without altering the total energy change of the reaction. The activity of enzymes is influenced by various factors, including temperature, pH value, ionic strength, and the presence of inhibitors and activators. Among them, pH value has a particularly significant impact on enzyme activity. The activity of enzymes usually reaches its maximum value within a specific pH range, which is called the optimal pH value of the enzyme. When the pH value of the solution deviates from this range, the activity of the enzyme will decrease or even completely lose. However, when the concentration of BES buffer is too high, it may have an inhibitory effect on enzyme activity. This inhibitory effect may be achieved through the following ways: 1. Changing the pH value of the solution: Although BES has good buffering capacity, when its concentration is too high, it may change the pH value of the solution, causing it to deviate from the optimal pH range of the enzyme. This change in pH value may cause structural changes in the enzyme, thereby affecting its catalytic activity. 2. Interaction with enzyme molecules: BES molecules may have non-specific interactions with enzyme molecules, such as electrostatic interactions, hydrogen bonds, etc. These interactions may alter the conformation of enzyme molecules, causing their active sites to be obscured or altered, thereby reducing the catalytic activity of the enzyme. 3. Impact on substrate binding of enzymes: Excessive concentration of BES may also affect the binding of enzymes to substrates. The binding of enzymes to substrates is the first step in enzyme catalyzed reactions, and if this step is disrupted, the entire catalytic process will be affected. BES molecules may compete with substrates for the active site of enzymes, thereby reducing the binding efficiency between enzymes and substrates. The impact of high BES concentration on experimental results The inhibitory effect of high BES concentration on enzyme activity will directly affect the accuracy and reliability of experimental results. In biochemical experiments, enzyme activity is often one of the key indicators for evaluating the success of the experiment. If the activity of the enzyme is inhibited, the interpretation and inference of the experimental results may be questioned. In addition, excessive concentration of BES may also affect the activity of other biomolecules, such as protein stability and cell membrane permeability, thereby further interfering with experimental results. In summary, the biological buffer BES has broad application prospects in biochemical experiments, but when its concentration is too high, it may inhibit enzyme activity, thereby affecting the accuracy and reliability of experimental results. Therefore, when using BES buffer, special attention should be paid to controlling its concentration and paying attention to the effects of other experimental conditions on enzyme activity. Through reasonable experimental design and operation, we can better utilize the advantages of BES buffer to provide a stable and reliable pH environment for biochemical experiments. As a BES raw material manufacturer, Desheng has advanced production technology and strict quality management system. The BES raw materials produced have high purity and stable quality, which can meet customers' demand for high-quality products. At the same time, Desheng focuses on technological innovation and research and development, continuously optimizing production processes, improving product performance, and reducing costs. If you have any relevant needs, please click on the website to inquire about details and purchase!

The 91st China International Medical Equipment Fair (CMEF) will be held grandly at the Shanghai National Convention and Exhibition Center from April 8th to 11th, 2025. This annual industry event, with its exhibition area of 300000 square meters, a large lineup of over 5000 exhibitors, and a rich agenda of more than 50 conferences and forums, has become an important platform for medical and health technology exchange and display at home and abroad. CMEF has successfully concluded on April 11th. Let's take a look back at the wonderful moments of Hubei Xindesheng Material Technology Co., Ltd. at this exhibition. New Desheng's full range of products shines at CMEF 1. Biological buffer series: Maintaining a stable pH environment is crucial in biological experiments and in vitro diagnostic reagent production. Xindesheng has a rich and diverse range of biological buffer products, with dozens of categories to choose from, which can meet the needs of different experimental and production scenarios. Its daily output can reach 5 tons, and its strong production capacity ensures the stability of market supply. The product has the advantages of high purity and stable process, and can also be customized according to customer specifications. 2. Color substrate series: New Desheng's color substrate products stand out for their high purity, high water solubility, color stability, and multi scene adaptability. On the basis of a wide range of available colorants, the detection system can be optimized to support multiple substrate detections with high detection sensitivity. 3. Luminescent reagent series: Chemiluminescent reagents are widely used in the field of in vitro diagnostics. New Desheng's products such as luminol, isoluminol, and acridine esters have reached analytical purity levels, with high purity and few impurities. In chemiluminescence reactions, these reagents can stably function with high luminescence efficiency and fast reaction speed. Among them, acridine ester has 7 different functional groups, which can meet the diverse needs of customers for immunological analysis and other experiments. 4. Enzyme preparation series: Xindesheng's enzyme preparations have the characteristics of high activity and stability. Through a strict quality control system, the consistency of each batch of products is ensured. Its products widely cover multiple testing items such as cardiovascular markers, infectious disease screening, and cancer diagnosis. 5. Blood collection tube reagent series: As a well-established manufacturer of a complete set of blood collection tube additives, Xindesheng has rich experience in research and development and production. Its product range is complete, the process is mature, and the quality is stable and reliable. Whether it is blood collection reagents such as coagulants, anticoagulants, or separation gels, Xindesheng can provide full category coverage and can be deeply customized according to customer needs, with agile response. In depth negotiations to jointly build a bridge of cooperation 1. Extensive collection of cooperation intentions: During the CMEF exhibition, the New Desheng booth at 8.2ZA31 attracted industry professionals from all over the world. Professional personnel always stick to their posts and warmly receive every visiting customer. Through in-depth communication, gain a multi-dimensional understanding of the customer's business needs, pain points, and future development plans. Many customers have shown strong interest in the application of New Desheng's biological buffer and enzyme preparation raw material products in research and development. During the exhibition, multiple potential cooperation intentions were collected from different regions and fields, laying a solid foundation for future business expansion. 2. Preliminary achievement of cooperation results: After several days of active negotiations, Xindesheng achieved fruitful cooperation results at the exhibition. We have signed strategic cooperation framework agreements with multiple well-known domestic and foreign medical device companies, covering multiple product fields such as luminescent reagents, chromogenic substrates, enzyme preparations, etc. Among them, a long-term cooperation has been established with an overseas in vitro diagnostic enterprise for the supply of biological buffer agents, and Xindesheng will provide customized buffer products for it. These collaborative achievements not only reflect the quality and technical strength of New Desheng's products, but also further enhance the company's visibility and influence in overseas markets. After the negotiations, many customers expressed that Xindesheng's professional team, full range of product lines, and stable supply capabilities make it an ideal partner for cooperation. New Desheng's Corporate Strength and Development Prospects Hubei Xindesheng Material Technology Co., Ltd. was founded in 2005. After 20 years of steady development, it has become a technology enterprise mainly engaged in research and development, production, sales, and service of blood test pre-processing reagents, in vitro diagnostic reagent raw materials, and biological buffering agents. The company ensures reliable and stable product quality through continuous technological innovation and strict quality control system, and has successfully passed the ISO9001 quality management system certification. With a strong production capacity of 5000 tons per year, it is able to provide stable product supply to customers, while also undertaking commissioned customization services and mass production services to meet the diverse needs of different customers. At the CMEF exhibition, Xindesheng fully demonstrated its corporate strength and product advantages, attracting the attention and communication of many industry professionals. Looking ahead to the future, Xindesheng will continue to uphold the development philosophy of innovation driven and quality first, continuously increase research and development investment, improve product quality and service level, and continue to deepen its cultivation in the field of in vitro diagnostic reagent raw materials, working hand in hand with customers to create a better future. Thank you again to every friend who met Xindesheng at the 2025 CMEF exhibition. We look forward to meeting again in the future to explore new opportunities for industry development and contribute to the progress of the medical and health industry.  

Biological buffering agents play a crucial role in biochemical experiments, especially in nucleic acid extraction and purification processes. Among them, PIPES, as an excellent biological buffer, has been widely used in the field of nucleic acid extraction and purification due to its unique buffering capacity and chemical stability. This article will delve into the application principles, advantages, and practical considerations of PIPES buffer in nucleic acid extraction and purification. Basic characteristics and buffering principle of PIPES PIPES is a zwitterionic buffer containing sulfonic acid groups in its molecular structure, which enables it to provide stable buffering capacity over a wide pH range. The pKa value of PIPES is approximately 6.8, indicating that it can effectively maintain the pH stability of the solution under physiological conditions. When acid or base is added to the solution, the sulfonic acid groups in PIPES molecules will accept or release protons, thereby neutralizing acid-base changes and maintaining a constant pH value of the solution. Application of PIPES in Nucleic Acid Extraction Nucleic acid extraction is a fundamental step in molecular biology research, and its key lies in ensuring the integrity and purity of nucleic acids during the extraction process. PIPES, as a buffering agent, plays multiple roles in nucleic acid extraction: 1. Maintain pH stability: PIPES can maintain the pH stability of the solution during cell lysis and nucleic acid release, preventing nucleic acid degradation due to changes in acidity or alkalinity. This is crucial for protecting the integrity of nucleic acids and improving extraction efficiency. 2. Enhance the interaction between nucleic acid and extraction reagents: A suitable pH value helps to enhance the interaction between nucleic acid and extraction reagents (such as phenol, chloroform, etc.), making it easier to separate nucleic acid from cell debris and other impurities. 3. Reduce non-specific binding: PIPES can reduce the binding of nucleic acids to non-specific components such as cell walls and membranes, thereby improving the purity of nucleic acid extraction.  Application of PIPES in Nucleic Acid Purification PIPES also plays an important role in the purification process of nucleic acids. The purification step aims to remove impurities introduced during the extraction process, such as proteins, polysaccharides, salts, etc., in order to improve the purity of nucleic acids. The buffering capacity of PIPES helps maintain pH stability during the purification process, ensuring the effectiveness of purification reagents and the stability of nucleic acids. 1. Auxiliary precipitation and washing: In the nucleic acid precipitation and washing steps, PIPES can serve as an auxiliary buffer to help remove residual impurities and salts while maintaining the stability of the nucleic acid. 2. Improve purification efficiency: By maintaining an appropriate pH value, PIPES can enhance the interaction between purification reagents and nucleic acids, thereby improving purification efficiency. In addition, it can also reduce non-specific binding and minimize interference from impurities.3. Protecting nucleic acids from degradation: During the purification process, PIPES can protect nucleic acids from enzymatic hydrolysis, oxidation, and other degradation effects, ensuring that the final nucleic acid obtained has high purity and activity. Conclusion In summary, PIPES, as an excellent biological buffer, plays an important role in nucleic acid extraction and purification processes. Its stable buffering capacity and chemical stability help maintain the pH stability of the solution, protect nucleic acids from degradation, and improve extraction and purification efficiency. However, strict control of experimental conditions and selection of appropriate concentrations and solvents are still necessary during use to avoid interference with experimental results. With the continuous development of biotechnology, the application prospects of PIPES in the field of nucleic acid extraction and purification will be even broader. Desheng has been producing and researching biological buffering agents for many years. The biological buffering agent series products have a professional R&D team. Currently, the products produced have been sold to more than 100 countries abroad, with guaranteed product quality and worry free after-sales service. If you need it, please feel free to contact us at any time. Looking forward to your call!

On April 8, 2025, the Shanghai National Convention and Exhibition Center welcomed the grand opening of the 91st China International Medical Equipment Fair (CMEF). As a benchmark for the medical industry both domestically and internationally, this exhibition, with the theme of "Innovative Technology, Leading the Future with Intelligence", has attracted nearly 5000 companies from more than 30 countries and regions to participate. The exhibition area covers 320000 square meters and is expected to attract over 200000 professional visitors. In this industry feast focusing on cutting-edge technologies such as AI medicine, gene sequencing, surgical robots, etc., Hubei Xindesheng Material Technology Co., Ltd. (booth number: 8.2ZA31) has become one of the focuses of the in vitro diagnostics (IVD) exhibition area with its advantages in the full range of IVD reagent raw materials. 1, Exhibition Overview: Empowered by Technology, Leading the Future with Intelligence This year's CMEF focuses on "AI+Robotics" and has built a full industry chain ecosystem covering 22 themed exhibition areas such as medical imaging, in vitro diagnostics, and medical electronics. Cutting edge technologies such as AI medicine, 3D bioprinting, and digital therapy, along with tens of thousands of innovative products, have been showcased, showcasing new achievements in medical technology. In addition, nearly a hundred forums and academic conferences were held simultaneously, focusing on hot topics such as policies and regulations, market development, and medical engineering transformation. Nearly a thousand industry experts gathered to explore the future trends of the medical industry. 2, New Desheng showcases its full range of products at CMEF In the in vitro diagnostic exhibition area, Hubei Xindesheng has set up booth 8.2ZA31 to comprehensively showcase its technical strength and product matrix in the field of IVD reagent raw materials. As a domestic IVD reagent raw material advantage R&D and production manufacturer, Xindesheng showcased its full range of IVD core raw materials, including: (1) Biological buffering agents: HEPES, MOPS, Tris, CAPS, Tris HCL, BICINE, TAPS, MOPSO, PIPES, etc; (2) Luminescent reagents: 7 types including luminol, isoluminol, and acridine ester; (3) Enzyme preparations: adenosine deaminase, pyruvate kinase, cholesterol oxidase, glycerol kinase, uricase-2, etc; (4) Chromogenic substrates: TOOS, MAOS, DAOS, TOPS, ADOS, ADPS, ALPS, etc Covering mainstream technology platforms such as chemiluminescence and enzyme-linked immunosorbent assay. During the exhibition, it attracted customers from multiple regions abroad to stop and exchange ideas. With the promotion of the policy of volume based centralized procurement, the profit margin of biochemical diagnostic reagents has narrowed, while immune diagnosis (especially chemiluminescence) and molecular diagnosis have become growth engines. As one of the few domestic enterprises with full supply chain capabilities, Xindesheng has demonstrated strong competitiveness in the import substitution process of luminescent reagents and chromogenic substrates. 3, Deeply cultivating raw materials for 20 years, empowering downstream manufacturers to diagnose the future As the crowd of CMEF gradually dispersed, what Hubei Xindesheng left behind at booth 8.2ZA31 was not only a highlight moment for product display, but also a firm step towards domestic substitution of IVD raw materials. From accurate regulation of biological buffering agents, to breakthroughs in sensitivity of luminescent reagents, and to the domestic and international market layout of enzyme preparations, Xindesheng has proven with 20 years of technological accumulation that raw material quality is the core driving force for the upgrading of diagnostic technology and an important guarantee for enterprise development. The New Desheng booth will continue to be open until April 11th. On August 23rd, ZA31, we sincerely invite you to explore the new future of IVD raw materials together!

In the fields of biochemistry and molecular biology, protein transmembrane technology, especially Western Blot (protein immunoblotting) experiments, is an important means of studying protein expression, localization, and function. The selection of biological buffering agents is crucial in ensuring the success of the experiment during this process. CAPS (3- (cyclohexylamine) -1-propanesulfonic acid) has demonstrated unique advantages as an efficient biological buffering agent in protein transmembrane processes. This article will delve into the application of CAPS buffer in protein translocation, including its chemical properties, mechanism of action, operational points, and specific applications in practical experiments. Chemical properties and buffering capacity of CAPS CAPS, The full name is 3- (cyclohexylamine) -1-propanesulfonic acid, which is a white crystalline powder with zwitterionic properties. This wide buffering range enables CAPS to provide a stable pH environment under various experimental conditions. As a biological buffer, CAPS not only has high chemical stability, but also is easily soluble in water, making it easy to prepare and use. In addition, CAPS has low toxicity and good compatibility with biomolecules such as proteins and nucleic acids, making it an ideal choice for biochemical experiments. The mechanism of CAPS in protein translocation In Western Blot experiments, proteins are first separated by SDS-PAGE electrophoresis and then transferred onto PVDF or nitrocellulose (NC) membranes. This process is called protein translocation. CAPS, as one of the main components of membrane transfer buffer, functions through the following aspects: 1. Maintain pH stability: The buffering capacity of CAPS can resist possible acid-base changes during membrane transfer, ensuring that proteins on the membrane maintain their natural conformation and charge state, which is beneficial for subsequent antibody incubation and detection. 2. Promote protein transfer: The components in the CAPS buffer (such as methanol) can affect the solubility and charged state of protein, thus promoting the transfer of protein from gel to membrane. Especially for high molecular weight proteins, CAPS buffer often exhibits better transfer efficiency. 3. Reduce non-specific binding: Some components in the CAPS buffer can reduce non-specific binding between protein and membrane or gel, thus improving the specificity and clarity of membrane transfer. The specific application of CAPS in protein translocation CAPS buffer is widely used in protein translocation, especially in Western Blot experiments. By using CAPS buffer, researchers can more accurately detect the expression levels of specific proteins in cells or tissues, thereby revealing their mechanisms of action in life activities. In addition, CAPS buffer is also suitable for other types of protein translocation experiments, such as spot hybridization, immunohistochemistry, etc. In these experiments, CAPS buffer can also provide a stable pH environment and efficient protein transfer efficiency, ensuring the accuracy and reliability of the experimental results. Conclusion In summary, the biological buffer CAPS plays a crucial role in the process of protein translocation. Its unique chemical properties and buffering ability make CAPS an indispensable tool in experiments such as Western Blot. By accurately preparing and using CAPS buffer, researchers can optimize the conditions for protein translocation and improve the accuracy and efficiency of experiments. With the continuous development of biochemistry and molecular biology, CAPS buffer is expected to be widely used in more types of protein transmembrane experiments, providing stronger support for life science research. Hubei Xindesheng Material Technology Co., Ltd. specializes in the production of biological buffering agents such as caps. Since its establishment in 2005, the company has a 20-year history of research and development and production. The production process is mature and stable, ensuring product purity of over 99%. The appearance is white powder, with good water solubility and small batch differences. If you have any recent purchasing needs, please click on the official website to learn more about the market or contact me!

In today's rapidly advancing medical technology, every technological leap is a significant improvement in ensuring human health. In the season of spring in 2025, the global medical industry's attention will be focused on Shanghai, and the 91st China International Medical Equipment Fair Spring Exhibition (CMEF) is about to grandly open. At this grand event that gathers the world's top medical technology and innovative achievements, Hubei Xindesheng Material Technology Co., Ltd. (hereinafter referred to as "Xindesheng") will showcase the latest achievements in China's in vitro diagnostic reagent field to the world with its star products, outstanding research and development capabilities, and forward-looking technological vision. Focusing on in vitro diagnostics, deeply cultivating the field of blood vessel additives for blood collection As a leader in the in vitro diagnostic reagent industry, Xindesheng has always been committed to the research and production of key products such as blood collection tube additives, chromogenic substrates, chemiluminescence reagents, and biological buffering agents. For this exhibition, Xindesheng carefully selected some highlight products, aiming to bring more efficient and safer diagnostic solutions to global medical customers. Serum separation gel: displays four different colors of serum separation gel, which not only meets the visual differentiation needs of different laboratories, but also ensures the purity and stability of samples with its excellent separation performance, providing a solid foundation for subsequent testing. Efficient coagulants and anticoagulants: New Desheng provides two types of coagulants suspension and high-efficiency coagulants powder for different detection needs, as well as reagents for different anticoagulant systems such as EDTA dipotassium, tripotassium, heparin sodium, heparin lithium, sodium citrate, potassium oxalate, etc. Whether it is rapid coagulation analysis or the need to maintain liquid samples for a long time, the best match can be found here to ensure the accuracy of test results. High performance silicification agent: Through unique silicification treatment technology, it effectively reduces the interaction between the inner wall of the blood collection tube and the sample, improves the efficiency of sample collection, and ensures the integrity of the sample, creating favorable conditions for high-precision detection. Biological buffer: a solid support for scientific research and clinical practice The selection of buffering agents is crucial in biological research. The series of biological buffering agents brought by Xindesheng, including tris, mops, hepes, caps, ADA, tes, etc., have become the first choice for many scientific research institutions and clinical laboratories due to their excellent pH stability, low toxicity, and wide application compatibility. These buffering agents not only support experimental needs in various research fields from molecular biology to cell culture, but also greatly promote innovation and development of in vitro diagnostic technology. Innovation driven, working together to create the future Xindesheng is well aware that innovation is the core driving force behind the advancement of medical technology. Therefore, the company continues to increase its R&D investment, introduce international advanced equipment and technology, and build a R&D team composed of professional researchers, committed to developing more high-quality products that meet international standards. Through continuous technological innovation and optimization, Xindesheng is gradually building a global sales and service network, providing more convenient and efficient solutions for global customers. CMEF stage, jointly painting a new chapter in healthcare The CMEF Spring Exhibition in 2025 is not only a stage for Xindesheng to showcase its latest technological achievements, but also a valuable opportunity for communication, mutual learning, and common development with industry colleagues. New Desheng looks forward to collaborating with partners, experts, scholars, and representatives of medical institutions from around the world to explore the future trends in the field of in vitro diagnostics, work together to promote the development of global healthcare, and jointly draw a beautiful blueprint for human health. At the upcoming CMEF event, Hubei Xindesheng Material Technology Co., Ltd. cordially invites you to visit our booth and witness the infinite possibilities of medical technology together, creating a brilliant future for a healthy world!

The selection of buffering agents is crucial for the success or failure of biochemical and molecular biology experiments. TAE (Tris acetate EDTA), as a commonly used electrophoresis buffer, plays an important role in DNA electrophoresis, RNA electrophoresis, and related molecular biology experiments due to its high compatibility, stability, and wide range of applications. This article will delve into the high compatibility of TAE buffer, including its composition, mechanism of action, advantages, and specific applications in experiments. Composition and characteristics of TAE buffer TAE buffer is mainly composed of Tris (trimethylaminomethane), acetic acid, and EDTA (ethylenediaminetetraacetic acid). Tris is a zwitterionic compound that provides the required conductivity for solutions and maintains pH stability. Acetic acid, as one of the main components of buffering agents, works together with Tris to form a stable pH environment. EDTA chelates divalent cations (such as Ca ² ⁺, Mg ² ⁺) to inhibit the activity of metal dependent nucleases and protect DNA from nuclease degradation. The characteristics of TAE buffer lie in its excellent buffering capacity and protective effect on DNA. Compared with other electrophoresis buffers such as TBE (Tris borate EDTA), TAE has a slightly weaker buffering capacity, but its protective effect on DNA is more significant. In addition, TAE buffer also has the advantages of low toxicity, high solubility, and easy preparation, making it an ideal choice in molecular biology experiments. The high compatibility mechanism of TAE buffer The high compatibility of TAE buffer is mainly reflected in the following aspects: 1. Wide pH range: TAE buffer buffer is suitable for most DNA and RNA electrophoresis experiments. Meanwhile, TAE buffer can resist the interference of external acids or bases, maintain the pH stability of the reaction system, and ensure the accuracy of experimental results. 2. Protective effect on DNA: EDTA, as an important component of TAE buffer, effectively inhibits the activity of metal dependent nucleases by chelating divalent cations, thereby protecting DNA from degradation by nucleases. This characteristic makes TAE buffer perform well in DNA electrophoresis experiments, ensuring the integrity and clarity of DNA fragments. 3. Low toxicity and high biocompatibility: The components of TAE buffer have low cytotoxicity to human cells and are easily compatible with biomolecules. This makes TAE buffer have broad application prospects in experiments such as cell culture and tissue sectioning. 4. Easy to prepare and store: The preparation process of TAE buffer is simple, convenient, and has good storage stability. This makes TAE buffer easy to manage and use in the laboratory, reducing experimental and time costs. Specific application of TAE buffer in experiments TAE buffer is widely used in biochemical and molecular biology experiments, including but not limited to the following aspects: 1. DNA electrophoresis: TAE buffer is one of the most commonly used buffer solutions in DNA electrophoresis experiments. By using TAE buffer, the size and quantity of DNA fragments can be clearly separated and observed, providing reliable data support for subsequent gene cloning, sequencing and other experiments. 2. RNA electrophoresis: Similar to DNA electrophoresis, TAE buffer is also suitable for RNA electrophoresis experiments. By optimizing electrophoresis conditions, efficient separation and detection of RNA fragments can be achieved, providing a powerful tool for RNA research. 3. Other molecular biology experiments: In addition to electrophoresis experiments, TAE buffer is also suitable for other molecular biology experiments, such as DNA extraction, purification, enzyme digestion reactions, etc. In these experiments, TAE buffer can provide a stable pH environment and appropriate ion strength, ensuring the accuracy and reliability of the experimental results. Conclusion In summary, the biological buffer TAE plays an important role in biochemical and molecular biology experiments due to its high compatibility, stability, and wide range of applications. By delving into the composition, mechanism of action, and advantages of TAE buffer, we can better utilize this tool, optimize experimental conditions, and improve experimental efficiency and accuracy. With advanced production technology and comprehensive sales services, we have won unanimous praise and continuous repeat purchases from numerous customers. If you also have a need to purchase biological buffering agents, please feel free to contact us at any time, or click on our official website for more detailed information. We look forward to establishing a long-term and stable cooperative relationship with you to jointly promote the development of the field of biological buffering agents.