China Wuhan Desheng Biochemical Technology Co., Ltd Company News

Since the spread of the new crown virus, the importance of hand disinfection has been greatly improved compared with that before. Carbomer, as an important component of the hand sanitizer gel, is naturally favored by the market. Now there are more and more manufacturers of carbomer in China. Large families are aiming at this bonus market and are prepared to make a big effort to make up for all kinds of enterprises during the epidemic. The loss situation, with so many kapham manufacturers rushing to come, buyers are puzzled. How can we find reliable manufacturers?   Here we need to tell you the purchase of Desheng carbomer products need to pay attention to a few points, you can refer to, avoid detours. 1. Understand the different models of carbomer There are many types of Carbomer, such as carbomer 980, Carbomer 940, Carbomer 934, Carbomer 941 and so on. Some of the differences between models are big and some are small. Therefore, we need to judge what we need according to our own needs. Different Desheng carbomer models have different uses, which are mainly divided into the following aspects: daily chemicals, food, pharmaceutical accessories, etc. It will save a lot of time if the buyer has a clear awareness of the needs and knows what products Desheng capom is used for.   2. Know the manufacturer of carbomer First of all, ask at least three suppliers for prices and compare them. In a word: a 5% reduction in purchasing cost is equivalent to a 20% increase in profit. Then, it is also important to pay attention to the reliability of the supplier's product quality while looking at the price!   Next is the delivery date. See if the supplier's delivery date is within your acceptance range. If you can get the supplier to give you a certain safety stock, that would be better!   Finally, service, whether the communication with suppliers is smooth. What kind of service the supplier promises to provide. If you only sell products without services, I believe you will not buy them again. You need to conduct a comprehensive evaluation and analysis of suppliers, including their strengths, weaknesses, problems, threats, etc. Thus, the company's strategy is organically combined with the internal resources and external environment of the company.   ①. The accuracy of the product content and various parameters is guaranteed, and the parameter table is provided, which can be compared and verified by customers. ②. Ensure the continuous spot supply within the customer's demand, which will not affect the normal use of customers. ③. If there are no special circumstances, the freight of all products will be borne by our company. ④. Except for special models, all products of the company have intellectual property certificate, so customers can use them at ease.

Carbomer 940 is a kind of highly hydrophilic anionic polymer. It is a white loose powder with strong hygroscopicity. It can rapidly swell in water, but it does not dissolve. The pH value of 1% aqueous dispersion is about 2.5 ~ 3.5, and its viscosity is low. When neutralized by alkali, the viscosity gradually increases with the gradual dissolution of macromolecules, forming a clear solution at low concentration, forming a semitransparent gel at a relatively large concentration. PH 6.5 ~ 7 has the greatest viscosity and consistency. When the dispersing solution of polymer glue is neutralized with alkali, a transparent and stable gel is formed.   From the above, we know that deshengcarbomer dissolution is not to say that water can be added, so how can we quickly and completely dissolve when using it?   Pre soaking method: A: 24 hours in advance, Desheng carbomer was dissolved in deionized water according to the actual production requirements. After the carbomer was allowed to absorb water naturally, no white powder could be seen on the surface and no white agglomerates could be seen in the solution, then the neutralizer (Carbopol: neutralizing agent = 1:1,2:1) was added, Kappa: 5% neutralizer solution = 1.4.5) adjust the pH value to about 7 to achieve thickening state. Use round tool or disperser and stir evenly at low speed.   B: homogenizer: in the uniform machine according to the actual production ratio, it is homogeneous, no white cluster can be seen, neutralizer is added, gel is formed, and then the vacuum emulsification pot is used to remove the air from the gel.   C: If the solution is dissolved by common methods, Desheng carbomer can not be stirred when added into water. If it is stirred while adding, it will make carbomer form a white water ball. The surface has absorbed water, but there is no water in it. After neutralization, many white spots of water can be seen, and a large number of bubbles are formed. The viscosity of carbomer is high, and the bubbles are difficult to eliminate by themselves. Even if the defoamer is added, it is difficult to eliminate the bubble. In this case, the bubble can only be eliminated by vacuumizing pot.

Serum separation gel is a kind of viscous fluid, which contains a large number of hydrogen bonds. Due to the association of hydrogen bonds, a network structure is formed. Under the action of centrifugal force, the network structure is destroyed and becomes a low viscosity fluid. When the centrifugal force disappears, the network structure is formed again and the fluid with high viscosity is restored. This property is called thixotropy. A kind of serum separation gel can be made by using this property. When the gel and the coagulated blood are centrifuged in the same tube, the gel forms a gel like isolation layer between the serum and the blood clot to separate the serum from the blood clot. Therefore, it can improve the recovery rate of serum and keep the serum in the original state, simplify the clinical test process and improve the work efficiency.   Nowadays, medical laboratory technology has entered a new era of full automation and microcomputer management. In the field of clinical laboratory, no matter in clinical chemistry, serology, immunology and other detection, most of the samples used need to separate serum. How to separate serum quickly and sufficiently and simplify the operation is an urgent problem for medical laboratory. The application of Desheng serum separation gel is expected to solve this problem.   The main use of serum separation gel is that it can form an isolation layer between the cell components of blood and serum, effectively prevent the material exchange between blood cells and serum, ensure the stability of serum components in a certain period of time, and make the detection results closer to the biochemical level. The blood coagulation time of blood can be shortened by adding Desheng coagulant separation gel, and the serum can be quickly obtained and processed After centrifugation, the separation layer can adhere to the test tube tightly. The serum can be directly absorbed by the automatic analyzer in the original state, or stored in cold storage. The long-distance transportation does not affect the detection results, but also avoids the influence of fibrin and hemolysis.   In addition, a series of processes including blood sample injection, serum separation, direct serum sampling by analyzer, blood sample preservation and waste disposal are all carried out in the same branch pipe, which can avoid the pollution of blood samples, prevent the virus infection in the blood, and ensure the biological safety of the inspection process.   At present, there are three types of separation adhesive: transparent, translucent and opaque. The conventional packaging includes 20kg / barrel and 25kg / barrel, plastic bucket and iron bucket.

Buffer solution is a kind of solution which can resist the influence of a small amount of strong acid and alkali outside, and maintain the pH value of the system basically unchanged. It is of great significance in the research of biochemistry. We often use Tris, bicine, caps and so on, but often can't accurately understand the difference between them, for this kind of problem, you can take a look here. Packaging of Desheng buffer   Tris (trimethylolmethylaminomethane) is widely used in the preparation of buffer solution in biochemistry and molecular biology experiments. In biochemical experiments, both TAE and tbe buffers (for nucleic acid dissolution) need to use Desheng Tris. Because it contains amino groups, it can react with aldehydes. Its structural formula, pH value changes greatly with temperature. Generally, the pH value decreases by 0.03 for every degree of increase in temperature. The buffer characteristic of Tris is weak base, and its PKA is 8.1 at room temperature (25 ℃). According to the buffer theory, the effective buffer range of Tris buffer is between pH 7.0 and 9.2.   Bicine (n, n-dihydroxyethylglycine) is an important raw material of antibody detection reagent and nucleic acid detection reagent in the field of in vitro diagnosis. It is a kind of white crystalline powder. It is soluble in water, insoluble in acetone, DMF, DMSO, DMAC and other organic solvents. The pH buffer range is 7.6-9.0, and the pKa value is 8.3 at 25 ℃. It is also a widely used buffer. It is used in enzyme reaction buffer and electrophoresis buffer with working concentration of 3-100ml.   Caps (3-cyclohexylaminopropanesulfonic acid) is mainly used in biochemical diagnosis kit, DNA / RNA extraction kit and PCR diagnostic kit. It is used as buffer for enzyme chemistry and HPLC separation of alkaline drugs. 3-cyclohexylaminopropanesulfonic acid (CAPS) can also support alkaline phosphatase activity and inhibit the growth of Aeromonas at pH 10.5, and can be dissolved in deionized water. After pH is adjusted to 11.0, caps can be used for the purification of fibronectin. Caps is also an important hydrophilic modifier, which can react with polyisocyanate under very mild reaction conditions and in the presence of suitable neutralizing amines, so as to prepare polyisocyanate products which can be emulsified into fine dispersion form in water and stored stably.   When a small amount of strong acid or alkali is added into the buffer solution, the pH value of the solution changes little, but if the amount of acid and alkali is large, the buffer solution will lose its buffering effect. This shows that its buffering capacity is limited. The buffering capacity of buffer solution is related to the concentration of components. After 15 years of independent R & D and production, Desheng technology has been widely recognized and used by customers in China's local market. Over the years, many well-known domestic manufacturers have been choosing and using Desheng products. We can also customize the buffer with different pH value according to the customer's requirements.

Generally speaking, the manufacturers of capom have their own professional technical team, but many of them do not have these. Carbomer is suitable for gel and cream because of its short rheological property, high viscosity, high clarity, low ion resistance and shear resistance.   Kapo, also known as carbomer (carbomer), is a very important rheology regulator. After neutralization, Carbomer is a gel matrix with thickening, suspension and other important uses. The process is simple, and its stability is good. It is widely used in emulsion, cream and gel. Kappa resin can be used as excellent suspending agent, stabilizer, emulsifier, transparent matrix of cosmetics and pharmaceutical excipient matrix.   At present, Desheng mainly sells two models of carbomer 940 and carbomer 980. Its business covers more than 30 countries. Most of its major customers come from Europe, America and other countries around the world. We can provide high-quality products and services. Compared with other manufacturers, our cost performance ratio is higher. With the public efforts of all the staff of the company, the sales volume of our card ohm continues to rise, and our products have also gained customers' support Agreed. During the epidemic period, many companies failed or dismissed their employees because of business stagnation. On the contrary, Desheng looked for opportunities in adversity, set up technology R & D centers, increased R & D investment, and obtained a very good market feedback. As a professional carbomer manufacturer, Desheng bases itself on domestic market, expands international market, sincerely serves the society and pursues high quality High quality, is gradually becoming a modern, ecological, scientific and technological enterprises, welcome to consult and cooperate.

Tris(hydroxymethyl)aminomethane is not only a common biological buffer, but also can be used to prepare related products. Such as bis Tris, Tricine, TES, Taps, etc. These are buffers often used in biochemical experiments and molecular biology experiments. Although its structure is not complex, there are not many domestic manufacturers that can really do Tris well. How do we choose Tris manufacturers? Let's analyze it through several points. 1. Whether the quality parameters meet the requirements High quality biological buffer Tris must have the following characteristics: pKa value between 6 ~ 8; good solubility in water system   It has little solubility in organic solvents; it has less permeability to biofilms and is less affected by concentration, temperature and ions in medium, and can form soluble complex with cations; it has excellent stability in dry or solution state, and can resist enzymatic or non enzymatic degradation; it has very small absorption value to visible light and ultraviolet light. 2. Is the stock sufficient A lot of customer consultation volume is above ton level, if there is not enough spot as support, on the one hand, there will be a lot of loss   Important customers, because it is difficult to have the willingness to continue the negotiation. On the other hand, if an order needs to take a long time to reach the customer's hands if it takes a long time for an order to arrive at the customer's hand under the condition of insufficient goods, the monthly output of Desheng can reach the ton level The goods are very timely, so there is no need to worry about it. 3. is the after-sales service guaranteed Whether we buy diagnostic reagents or any other products, we would rather spend more money than choose a manufacturer with after-sales guarantee   Home. In this way, when we buy products, we will have a sense of steadiness in our hearts. The same is true for Tris, which is more reliable for businesses with service commitment. If they can guarantee that they can return and exchange without worry if they have quality problems, it shows that they are very trustworthy. Even if there are problems in the use process, they will not worry at all.   4. Whether to adopt the optimal scheme to synthesize Trometamol There are two synthetic methods of Trometamol: direct method and two-step method. However, the yield and cost of Trometamol produced by direct hydrogenation method are lower than those by two-step method. However, the purity of Trometamol produced by direct hydrogenation method is high, which meets the requirements of reference reagent for purity of Trometamol, and the process is stable and reasonable, which is especially suitable for the production of kilogram grade Batch products, the process is simple and reasonable, product pass rate is high.

Nsp-sa-nhs is not only the internal salt of acridine sulfonylhydrazine amine, but also the active ester. Compared with the pure acridine ester, nsp-sa-nhs has better hydrolysis resistance and better stability when the pH value is less than 4.8.   Appearance The appearance of nsp-sa-nhs is golden yellow powder, which may be in the form of yellow solid in the frozen state. However, after thawing, it is a loose powder with a very fine texture. Therefore, it is necessary to be careful when loading and unloading to avoid waste caused by spilling.   Packing Chemiluminescence reagents are usually stored in opaque bottles, and nsp-sa-nhs is no exception. Brown bottles are used, including 10mg and 50mg, of course, 1g large package is also available.   Price Nsp-sa-nhs is relatively moderate among six acridine esters with different groups, and the price will be determined according to the amount of customers. The reason is that small amount of sub packaging will cause the loss of the product itself. In fact, the price fluctuation is still relatively large, 200-60 yuan / mg. Of course, if it's a dealer, the price will be more expensive.   Preservation Nsp-sa-nhs is the same as other acridine esters. It is sealed and protected from light, stored at 2-8 ℃ for one year, and can be stored for a longer time at - 20 ℃. Moreover, the photoquantum yield of nsp-sa-nhs and protein conjugates does not decrease when stored at room temperature for 4 weeks. This is also a major feature of nsp-sa-nhs.   Because the essence of the antibody is protein, it contains amino groups, which can directly react with NSP-SA-NHS and couple.   Cas199293-83-9, c32h31n3o10s2, molecular weight 681.7, is commonly used in chemiluminescence labeling, immunoluminescence, etc. The purity is higher than 98% according to different manufacturers. This acridine salt and nsp-dmae-nhs are the two most commonly used acridine ester series.

The vacuum blood collector consists of three parts: vacuum blood collection vessel, blood collection needle (including straight needle and scalp blood collection needle) and needle holder. The vacuum blood collection vessel is the main component, which is mainly used for blood collection and preservation. A certain amount of negative pressure is preset in the production process. When the blood collection needle enters the blood vessel, due to the negative pressure effect in the blood collection vessel, the blood automatically flows into the blood collection vessel; at the same time, various additives are preset in the blood collection vessel, which can fully meet the clinical multiple comprehensive blood detection, safety, sealing, sealing and sealing Convenient transportation. Vacuum blood collection and additives Vacuum blood collection is generally divided into the following categories: 1. Dry empty tube without additives: the inner wall of the blood collection vessel is evenly coated with the agent (silicone oil) to prevent wall hanging. It makes use of the principle of blood natural coagulation to coagulate the blood. After the serum is naturally precipitated, it is centrifuged. It is mainly used for serum biochemistry (liver function, kidney function, myocardial enzyme, amylase, etc.), electrolyte (serum potassium, sodium, chlorine, calcium, phosphorus, etc.), thyroid function, drug detection, AIDS detection, tumor markers, serum immunology.   2. Coagulant tube: the inner wall of the blood collection vessel is evenly coated with silicone oil to prevent wall hanging, and Desheng coagulant is added at the same time. The coagulant can activate the fibrin, make the soluble fibrin into the insoluble fibrin polymer, and then form the stable fibrin clot. It is generally used in emergency biochemistry.   3. Blood collection vessel containing separation gel and coagulant: the wall of the tube is silicified and coated with coagulant, which can accelerate the blood coagulation and shorten the test time. The separation gel is added in the tube, which has a good affinity with pet tube, and indeed plays an isolation role. Generally, even on the ordinary centrifuge, Desheng serum separation gel can completely separate the liquid components (serum) and solid components (blood cells) in the blood and accumulate in the test tube to form a barrier. After centrifugation, the serum does not produce oil droplets, so it will not block the machine. It is mainly used for serum biochemistry (liver function, kidney function, myocardial enzyme, amylase, etc.), electrolyte (serum potassium, sodium, chlorine, calcium, phosphorus, etc.), thyroid function, drug detection, AIDS detection, tumor markers, serum immunology.   4. Blood collection vessel with anticoagulant in the tube: 1) Blood collection vessels containing heparin sodium or heparin lithium: heparin is a kind of mucopolysaccharide containing sulfate group, with strong negative charge, which can strengthen the inactivation of serine protease by antithrombin III, thus preventing the formation of thrombin and preventing platelet aggregation. Heparin tube is generally used for the detection of emergency biochemistry and hemorheology, which is the best choice for electrolyte detection. It can't be used to count and classify white blood cells, because heparin can cause leukocyte aggregation.   2) EDTA is a kind of amino polycarboxylic acid, which can effectively chelate calcium ions in blood. Chelated calcium will remove calcium from the reaction point, and will prevent and terminate the endogenous or exogenous coagulation process, thus preventing blood coagulation. Compared with other anticoagulants, it can agglutinate blood cells and blood cells Therefore, Desheng EDTA salts (2k, 3k, 2Na) are usually used as anticoagulants. It can not be used for coagulation, trace elements and PCR.   3) Blood collection vessels containing sodium citrate anticoagulant: sodium citrate plays an anticoagulant effect by acting on calcium ion chelation in blood samples, which is recommended by National Committee for clinical laboratory standardization (NCCLS) as 3.2% or 3.8%, and the ratio of anticoagulant to blood is 1:9, which is mainly used in fibrinolysis system (prothrombin time, thrombin time, activated partial thrombin time, fibrinogen). When taking blood, pay attention to take enough blood volume to ensure the accuracy of the test results. Immediately reverse and mix the blood 5-8 times.   4) The tube contains potassium oxalate / sodium fluoride (1 part of sodium fluoride and 3 parts of potassium oxalate): sodium fluoride is a weak anticoagulant, which can prevent the degradation of blood glucose and is an excellent preservative for blood glucose detection. Attention should be paid to slow inversion and mixing when using. It can't be used to detect urea, alkaline phosphatase and amylase.

Luminol is one of the most commonly used chemiluminescence reagents. It can react with a variety of oxidants and has a high luminescence quantum yield and good water solubility. Luminol chemiluminescence system is widely used in many fields such as chemistry, pharmacy, environmental science, food science and clinical medicine. In luminol chemiluminescence system, the most commonly used oxidant is hydrogen peroxide, but hydrogen peroxide is unstable. The chemiluminescence reaction with luminol is slow and the luminescence intensity is low. To solve this problem, researchers have developed some novel and efficient luminol chemiluminescence systems without hydrogen peroxide.   Researchers such as Xu Baoguo, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, mixed luminol, thiourea dioxide and a solvent to prepare a luminol-thiourea dioxide chemiluminescence system, in which thiourea dioxide and luminol can be produced by reaction Chemiluminescence, thiourea dioxide has good thermal stability, is safe and non-toxic, has no pollution during production and use, has a fast chemiluminescence reaction with luminol, and has high luminous intensity. Compared with the luminol-hydrogen peroxide chemiluminescence system, the maximum luminescence intensity of the luminol-thiourea dioxide chemiluminescence system is increased by 20 times.   Liu Wei of Shaanxi Normal University and others used Co Fe PBA NAFSs aqueous solution, luminol working fluid and paper matrix containing hydrophilic and hydrophobic regions to form a new type of luminol chemiluminescence system, in which Co Fe PBA NAFSs is anisotropic KCoFe self-assembled nanoparticles with cubic frame structure. In this chemiluminescence system, Co-Fe PBA NAFSs can catalyze luminol to produce strong chemiluminescence on the paper substrate. Co-Fe PBA NAFSs act as a catalyst and sensitizer. It can catalyze luminol to produce strong chemiluminescence, and it only takes about 3.7 seconds from the contact of luminol with Co-Fe PBA NAFSs solution to the maximum absorption peak. , The reaction rate is sensitive and fast.   Because of its simple structure and easy synthesis, luminol is widely used as a luminescence reagent for various chemiluminescence analysis and detection. With the development and update of chemical analysis technology, more novel and efficient luminol chemiluminescence systems will emerge in the future. Desheng Technology is a manufacturer of chemiluminescence reagent raw materials, the purity of luminol produced is ≥99%, and the luminous efficiency is high. We can also provide high-quality raw materials such as isoluminol, 6 commonly used types of acridinium esters, and professional after-sales service to allow customers to enjoy one-stop purchase. If you have any questions, please click on the official website to consult our customer service staff.

Desheng Technology is a new technology enterprise specializing in the research and development, production and sales of blood collection tube additives. It has 15 years of experience in the production of blood collection tube additives. The main components of Desheng's blood coagulant are composed of thrombin, alcohol, silica powder, emulsifier, surfactant, etc., which are suspended liquids. Serum is one of the main specimens tested in clinical biochemical and immunological tests. At present, the methods of obtaining serum samples in medical institutions are mainly obtained by centrifugation after collecting venous blood after the blood is completely coagulated. Under normal circumstances, it takes more than 60 minutes for an isolated blood sample to completely coagulate, or even not coagulate, which is difficult to meet the needs of rapid laboratory testing.   Under normal circumstances, it takes a long time for the collected blood sample to coagulate naturally at room temperature (2-35℃). Generally, it takes more than 60 minutes for glass tubes and more than 90 minutes for plastic tubes. Since the clinical needs laboratory to provide rapid and accurate laboratory biochemical, immunological and other testing indicators, if the collected blood samples are not processed, it is difficult to meet the clinical needs in time, especially for emergency patients, it is necessary to obtain fast and accurate test results. . The traditional method of promoting blood coagulation is mainly to add kaolin and cephalin to blood samples after collection that can promote blood coagulation. However, with the advancement of clinical laboratory testing methods, some automated and intelligent biochemical and immunological Testing instruments are constantly updated and used for clinical testing and analysis. While the sensitivity and accuracy of these automatic analysis instruments continue to improve, the requirements for specimens are also increasing.   Procoagulant principle of blood coagulant: Activate part of the coagulation factors in plasma and platelets, promote the formation of thromboplastin and fibrin clots, accelerate the contraction of blood clots, and achieve the purpose of rapid serum separation.   Usage and dosage of coagulant: The accelerator can be sprayed by machine or added manually. In the process of adding, it must be stirred continuously to keep the suspension uniform and fully ensure the consistent addition of various active ingredients.   2. Mechanical stirring, electromagnetic stirring, pneumatic stirring, etc. can be used to keep the suspension uniform, and the stirring speed can be adjusted according to actual conditions. 3. After the addition is complete, the coagulant needs to be dried (not needed for non-organic solvent coagulant). The hot air drying temperature can be 40-80℃, and the time is 7-120S; the drying temperature in the drying oven or drying room is about 40C, and the time is subject to thorough drying.   4. Add 20-30ul blood coagulant, it can quickly coagulate 2-5ml blood at 20-25℃. When the ambient temperature is lower than 20°C, or the blood volume is more than 5ml, the amount of coagulant added should be appropriately increased. If irradiation sterilization is required, it is recommended to increase the additive dosage of coagulant by about 20%.   Blood coagulant accelerates the speed of blood coagulation and provides convenient conditions for testing. Desheng is one of the few manufacturers that produces a full set of additives for blood collection tubes. The additives produced include heparin sodium/lithium, EDTA dipotassium/tripotassium, coagulant and sodium citrate, potassium oxalate, separation gel, etc., which are purchased for customers Provided convenience.

In chemiluminescence immunoassay experiments, there are two types: plate and tube. Among them, tube chemiluminescence will use magnetic beads as a carrier for adsorbing acridinium ester-labeled antibodies or proteins to facilitate the washing and separation of labeled antibodies. The magnetic beads here are a kind of magnetic biological microspheres, which are nanomaterials. In fact, there are many types of nanomaterials in the in vitro diagnostic reagent industry.   The magnetic beads newly developed by the company are different from the original serum separation gel and high molecular polymer materials such as carbomer. Magnetic beads are a kind of more advanced nano materials. Because nanomaterials have unique optical, magnetic, electrical and thermal properties, they can be used to generate different types of detection signals, amplify the intensity of detection signals, and simplify the detection process. Therefore, in vitro diagnostic technology based on nanomaterials has broad application prospects. Nanomaterials can be applied to the detection of nucleic acids, proteins, small molecules, bacteria and viruses. In Vitro Diagnostic Reagents and Magnetic Bead Materials With the rapid development of clinical medicine diagnosis and treatment technology, many traditional and conventional in vitro diagnostic technologies can no longer meet the needs of clinical medicine development. People have higher and higher requirements for the sensitivity, accuracy and specificity of clinical diagnostic analysis. Therefore, nanomaterials Also came into being. In particular, because nanomaterials have a much higher specific surface area than macroscopic materials, they can provide a lot of space to modify different molecules on their surfaces, making them play an important role in applications such as bioanalysis and biosensors. Using these surface-modified nanomaterials with different molecules can selectively detect small molecules, nucleic acids, proteins and microorganisms.   There are many different types of nanomaterials, such as semiconductor quantum dots, gold nanoparticles, and magnetic nanoparticles. Among them, magnetic beads are a kind of magnetic nanoparticles, which are widely used in the field of in vitro diagnostic reagents. Nanomaterials can be used for the detection of nucleic acids and antibody proteins in chemiluminescence immunity according to different types; some can be used for enzyme-linked immunosorbent assay (ELISA) immunoassays and DNA microarray detection, etc.; others are used for tumor cell detection and bacteria Detection, virus detection, and tracing of small molecule drugs in living cells, etc., have a very broad application prospects.   In the past, acridine esters chemiluminescence reagents mainly relied on imports. Now, due to the good market feedback of the acridine esters developed by Desheng, the magnetic bead materials developed are mainly used for chemiluminescence experiments. Other in vitro diagnostics will be considered later. Application in experiment.

Carbomer is a white, loose powder with strong hygroscopicity and acidity. It is soluble in water, glycerin, and ethanol. It has the characteristics of a colloidal solution. The usual concentration is 0.1% to 3%. Due to the low viscosity, when the alkali is neutralized, the viscosity gradually rises as the macromolecules gradually dissolve, forming a clear solution when the mass fraction is low, and a translucent gel when the mass fraction is large. Carbomer not only It is widely used in daily chemicals. It can also be used as a promising new pharmaceutical excipient. The following introduces some problems that should be paid attention to when using carbomer to make gels. Desheng Carbomer 980 Gel Carbomer model selection According to the different uses of the prepared gel, choose different types of CP. CP934 has the strongest adhesion and is more suitable for cavity administration, such as commonly used nasal bioadhesives, vaginal bioadhesives, rectal bioadhesives, oral Containing or oral bioadhesives, etc. CP940 has strong adhesion to the skin surface and good spreadability, which can prolong the residence time of the drug on the skin surface and increase the effect of the drug. It is widely used in skin diseases and can absorb tissue exudate, which is beneficial to the exclusion of secretions. Suitable for treatment of seborrheic skin diseases. CP1342 has strong ion resistance, which is more suitable in the presence of electrolyte.   Carbomer quality score selection According to the different viscosity of the required gel, generally choose the mass fraction of CP from 0.5% to 3%. When formulating skin care products, the final mass fraction of CP should be controlled to be less than or equal to 0.8%. When it is greater than 0.8%, it is easy to form a film and the skin feels bad. In order to achieve the desired consistency, CP can also be used in combination with carmellose, sodium alginate, polyethylene glycol, polyvinylpyrrolidone, etc. to achieve a synergistic thickening effect. Choice of pH regulator In order to make CP form a more stable gel, its pH needs to be adjusted from 5 to 11. The CP neutralizer can be sodium hydroxide, potassium hydroxide, potassium bicarbonate, borax and triethanolamine in polar systems, and laurylamine and amine stearate can be used in non-polar systems.   Choice of moisturizer Since the gel will lose water during storage, it will dry and harden, forming a dry micelle which is not easy to spread. It is necessary to add a moisturizer to maintain the stability of the dosage form and prevent the skin from drying out. Commonly used humectants include polyols such as glycerin and propylene glycol.   Selection of preservatives Carbomer itself has no nutrition and does not support the growth of bacteria and molds, but it cannot prevent the growth of bacteria and molds using the nutrients present in the gel system, so different preservatives should be selected according to the situation, such as sodium benzoate and p-hydroxybenzene Formate (parabens) and ethanol, etc. Preservatives can also be combined to reduce dosage and achieve synergistic antibacterial effects.   As a professional carbomer manufacturer, Desheng can provide two models of carbomer 940, carbomer 980, high-quality products and services, and higher cost performance than other manufacturers. Desheng has always been favored by customers. This is definitely the driving force for Desheng to move forward. In order to thank new and old customers, we are now launching = a year-end promotional event, the price is as low as 100 yuan/kg, and the opportunity is not to be missed. Please come to consult and order!