China Wuhan Desheng Biochemical Technology Co., Ltd Company News

What is nucleic acid detection, that is, after collecting human secretions, under laboratory conditions, through the analysis of virus RNA gene sequence, using PCR amplification method for detection, clinical etiology diagnosis. At present, nucleic acid detection is the most effective method to determine whether the patient is infected with the virus as early as possible, and to detect and treat the virus as early as possible.   Nucleic acid test swabs are divided into two types: nasal swab and pharyngeal swab. During the sampling process, the doctor will use a swab like a cotton swab to wipe the secretion around the pharynx, tonsil or nasal cavity. As long as it is "gently wiped", it is quick and painless. Medical institutions will disinfect the test area, and medical staff will also disinfect their hands to avoid cross infection. Generally speaking, the sampling process is safe and clean, and there is no need to worry about the risk of infection.   Two types of virus preservation solution of Desheng So what are the types of swab preservation solution after sampling? Swab preservation solution can be divided into inactivated and non inactivated. At the beginning, almost all the swab preservation solutions used in the market are direct preservation of live virus, that is, non inactivated swab preservation solution. This preservation method will lead to higher infection risk for medical staff in sampling, transportation and detection. In view of this situation, anti epidemic measures should be taken It is very necessary to use the swab preservation solution to inactivate the virus directly.   It should be noted that: while inactivating the virus, we should also consider whether the preservation solution can stably preserve the integrity of the virus nucleic acid, so as to avoid the degradation of the nucleic acid in the sample before detection, resulting in "false negative" nucleic acid detection. The inactivated virus preservation solution produced and developed by Desheng can avoid this kind of problem.   In short, nucleic acid detection swab preservation solution can be divided into two categories. The inactivated preservation solution produced and developed by Desheng is a swab preservation solution with cleavage function, which contains cleavage salt of inactivated virus and cleavage protein to protect nucleic acid. Virus preservation and cleavage are completed in one step.   The other is the non inactivated preservation solution. On the contrary, it can protect the integrity of protein and nucleic acid of the virus. In addition to nucleic acid detection, it can also be used for virus culture research. The operating environment requirements of the two preservation solutions are not the same. The inactivated environment does not need to be so strict. Because of the risk of virus infection, the operating environment requirements of the non inactivated type are different Higher.

Serum separation gel is a kind of hydrophobic organic compound, it is a viscous fluid, its structure contains a lot of hydrogen bonds, because of the association of hydrogen bonds to form a network structure. Under the action of centrifugal force, the network structure is destroyed and becomes a low viscosity fluid. When the centrifugal force disappears, the network structure is formed again and the fluid with high viscosity is recovered.   Serum separation gel is a material used to separate serum (plasma) and blood cells. Its main purpose is to form an isolation layer between blood cell components and serum, prevent material exchange between blood cells and serum, ensure the original characteristics of blood samples within a certain period of time, and make the detection results more accurate. In the field of clinical laboratory, no matter in clinical chemistry, serology, immunology, most of the samples need to be separated from the serum. It can also be used with heparin, EDTA and sodium citrate.     The key factors of separating gum are as follows   A. Specific gravity: 1.045-1.065g/cm3, between the specific gravity of serum (plasma) and blood cells. The PrP tube has two specific gravity of 1.055 and 1.078, which are used to separate platelet and serum components respectively;   B. Viscosity: between 100000-200000 Li poise (dynamic viscosity measured by rotary viscometer).   C. Thixotropy: when an object (such as a coating) is sheared, its consistency decreases. When it stops shearing, its consistency increases. When it is sheared, its consistency increases. When it stops shearing, its consistency decreases. That is, the property of changing at one touch. This is the key to the separation layer formed by centrifugal force.   D. Physiological inertia: the separation gel is in direct contact with the blood, and can not react with the blood, otherwise it will affect the blood composition, cause significant differences in test results, and lead to misdiagnosis. Blood cell is a kind of special delicate material, a little careless will most likely cause hemolysis, affect the accuracy of test results.   E. Radiation resistance: the blood collection vessel is required to be sterile, and gamma ray irradiation is generally used for sterilization. After gamma ray irradiation, the properties of the gel can not change significantly, including specific gravity, viscosity, thixotropy and physiological inertia. In general, gamma ray is produced by cobalt 60, and the radiation dose is generally in the range of 8-25kgy; the radiation dose is determined by the initial colony number of blood collection vessel.   G. Stability: on the one hand, it requires the stability of the separation adhesive after long-term storage, and it should be stable for at least two years, and the physical and chemical properties should not change significantly. In addition, there is no reaction between the separation gel and various additives in the blood collection vessel, which affects the effectiveness of the reagent and thus affects the blood detection.   Serum separation gel is still a glue with viscosity, and the viscosity has a certain relationship with temperature. When the temperature is too low and the weather is cold, the viscosity of serum gel increases, and the process of adding glue is difficult. In winter, the glue is heated. No problem under 80 ℃. Desheng has never stopped in the blood vessel additive. We want to use our products to tell all customers that your choice is right.

Acridine esters have been widely used in the field of life science, mainly because of their high luminous efficiency, mild reaction conditions, only H2O2 and dilute alkali are needed, and no catalyst is needed to stimulate chemiluminescence (CL). The CL reaction mechanism of these compounds is characterized by the dissociation of the luminescent group and the modified group, the luminescent efficiency is not limited by the length of the connecting arm, and the Photofragmentation effect is small. Through the modification of its structure, the possibility of acridine esters involved in the establishment of ultramicro immunochemical analysis was greatly increased.     Application of acridine ester   1. Determination of tissue type plasminogen activator activity by acridine ester luminescent method Thrombotic disease is one of the main diseases endangering people's life safety. Among several fibrinolytic drugs, tissue type plasminogen activator (t-PA) is favored by the medical community because of its specific fibrinolytic effect. Many tissues of the body contain t-PA, but it can not be extracted in large quantities because of its small amount. Genetic engineering products have been used in clinic in the world, and the development of t-PA genetic engineering products in China is stepping up. It is urgent to establish a sensitive, simple and low-cost detection method.   At present, acridine esters have been successfully synthesized in China, and the properties of acridine esters have been comprehensively analyzed, which provides a favorable condition for the establishment of a sensitive and low-cost quantitative method for t-PA activity. This method was used to determine the expression of RT PA in human melanoma t-PA (MT PA) cells and Chinese hamster ovary (CHO) cells, and the results were consistent with that of fibrin agar plate assay (FAPA). The changes of t-PA activity in plasma of healthy people before and after venous blood flow occlusion were significantly different. The activity of plasma t-PA in patients with lung cancer was significantly higher than that in normal people. Therefore, this method is expected to be used in clinical diagnosis and basic theoretical research of some diseases.   2. A new chemiluminescence system of xanthine oxidase acetaldehyde acridine   Acetaldehyde is oxidized to acetic acid by oxygen in the air under the catalysis of xanthoxygenase, and hydrogen peroxide is produced at the same time; hydrogen peroxide produced by enzyme reaction oxidizes 10-methyl-9-methylphthalophenyl acridine ester fluorosulfonate in alkaline medium to produce chemiluminescence.   3. Application of acridine ester labeled antibody in determination of antibody level of tuberculosis patients   Acridine antibody conjugates can be used for the determination of antibodies produced by bacteria, viruses and human autoimmunity. At present, there are at least 30 kinds of autoimmune diseases. As long as the antigen of the disease is prepared and used to coat the solid phase, the acridine ester human IgG antibody marker can be used for determination, which provides meaningful information for clinical diagnosis and pathogenesis research.   Desheng has six kinds of acridine ester products with different groups: acridine ester dmae-nhs, acridine ester nsp-dmae-nhs, acridine salt nsp-sa-nhs, acridine salt nsp-sa-nhs, acridine hydrazide nsp-sa-adh, acridine ester me-dmae-nhs. In addition to acridine ester series of chemiluminescence reagents, we also have luminol and isoluminol and other products.

Now there are various cosmetic brands, and their components are various. You may as well look at the major cosmetic components, and you will find that there is a "shadow" of carbomer. Such as eye gel, Estee Lauder, Laneige sleep mask and so on, all of which will undoubtedly use carbomer modulated gel.   Carbomer is a crosslinked acrylic polymer, which can be neutralized by alkaline material to form transparent gel after being dissolved in water. After carboxy group is ionized by carbomer neutralization, the molecular chain is dispersed and extended due to mutual repulsion of negative charges, showing a state of great expansion and viscosity. It can produce highly effective thickening effect at very low dosage.   The low concentration of additives (such as POM) can make the oil insoluble and rheological. Therefore, Carbomer is widely used in personal care products, such as skin care, hair care products, toothpaste and other products. Therefore, Carbomer can be found in many international cosmetics.     Carbomer is the key raw material for making skin care products and glue. After the neutralization, the carbomer gel is easy to absorb, and has a very important influence in skin care products. It can make the various ingredients in skin care products integrated and make them fit in a stable state. What is the magic card's function in cosmetics?   1. Skin care   Carbomer has a significant maintenance effect on human skin. It has a certain infectious power on human skin. It is usually applied in skin care products added with Carbomer, which can maintain the skin, reduce the irritation and damage to human skin and skin mucosa, and avoid a variety of allergic symptoms.   2. UV resistant   Carbomer has a certain specificity, it can improve the resistance of human skin to ultraviolet light after wiping on the surface of the body skin, and reduce the damage of ultraviolet light on the body skin. The sunscreen isolation cosmetics added carbomer has a very ideal sunscreen isolation effect, can avoid rough skin, and can also avoid the skin being burned by ultraviolet light.   3. Reduce viscosity   Carbomer has a certain degree of looseness, and it is a kind of slightly acidic material with strong water absorption. When making skin care products, Carbomer can be added in an appropriate amount. It can reduce the consistency of this material and keep their characteristics stable. In today's industrial production, Carbomer is the key raw material for making skin care products and skin care products.   4. Anti inflammation and sterilization   Carbomer is also a kind of pure natural medicinal value ingredient, which can eliminate inflammation and bacteria. Carbomer eye drops sold in the pharmaceutical market today are therapeutic drugs made of carbomer as the key raw material, which have excellent effect in removing inflammation around human eyes.   5. Ensure the quality of skin care products   Carbomer is an organic chemical neutralizer, which has a very key influence in the production of skin care products. It can make a variety of ingredients in skin care products integrated together, and make them in a stable and suitable situation. The skin care products added carbomer will have excellent cultivation substrate, and you will feel very comfortable after wiping on the skin.   Desheng is a manufacturer of carbomer in China. Its carbomer series products include carbomer 940 and 980. It has been proved by many tests that all indexes meet international standards. Desheng cabom has been exported to more than 20 or 30 countries, and has rich experience in export. If you need to solve the problem or need, you can click the official website to consult our customer service.

MOPS is a zwitterionic biological buffer. It is a white powdery solid at room temperature, with high hydrophilicity and excellent water solubility (1000 g/L at 20°C). When MOPS is dissolved in water, the appearance of its aqueous solution is colorless. This is just its basic information, if you want to know more, then you have to look down.     What is the recommended use of MOPS?   1. The operation that can separate RNA by agarose gel electrophoresis; 2. Used for protein purification in chromatography; 3. Measure absorption in ultraviolet/visible spectrophotometry and use cyclic voltammetry to study redox characteristics; 4. The electron transfer mechanism in nitrogenase; 5. Separate nucleic acid and protein by electrophoresis; 6. In the control of medium pH value of 5, including cell culture medium for yeast, bacteria and mammalian cells; 7. It has been used as a buffer component of charcoal yeast extract culture medium; 8. It interacts with the peptide backbone of bovine serum albumin, resulting in a net stabilization of the protein.   What questions should you consider before choosing MOPS for your research?   1. When used for mammalian cell culture, the MOPS buffer concentration should not be higher than 20mM 2. Although most studies have found that there is almost no complex between the mop and the metal, some studies have found that interference may occur due to the formation of metal complexes; 3. It can change the interaction of lipids; 4. MOPS can affect the thickness and barrier properties of the rat endothelial surface layer; 5. It interacts with DNA and forms a complex; 6. It can slightly affect the mRNA expression of bovine embryos produced in vitro; 7. It can be oxidized by H2O2, but due to its slow oxidation, it is not expected to have a significant impact on the biological system; 8. In the presence of glucose, autoclaving can partially degrade MOPS.

The determination of free fatty acid (FFA) in serum is an important biochemical test index, and FFA is closely related to human health. Because serum components are complex and there are many types of FFA, the detection is affected by many factors, so the chromogen substrate TOPS is usually used to determine FFA.   Chromogen substrate TOPS reagent   Chromogen TOPS determination FFA steps:   1. In the container, first add the buffer solution weighed according to the formula ratio, and then add ATP, coenzyme A, 4-aminoantipyrine, ion activator (magnesium chloride), stabilizer (BSA), and preservative in sequence. After adding proper amount of water, add surfactant, adjust the pH to pH 6-9 with concentrated hydrochloric acid, add acyl-CoA synthase at last, then stir and filter, and add distilled water to the filtrate to obtain reagent A quantitatively.   2. Add buffer to the container, then add chromogen TOPS, water, surfactant in turn, adjust the pH to pH 6-9, finally add HRP and acetyl CoA oxidase, then stir and filter, and then add distilled water to the resulting filtrate to a quantitative amount Reagent B is obtained.   3. Fill the above reagents into vials and store them at 2-8°C. Take the reagent A and the sample and mix them in a certain ratio, incubate for a certain period of time, and read the absorbance value A1; add the reagent B and mix evenly, incubate for a certain period of time, and read the absorbance value A2. FFA concentration in the sample=standard solution concentration Χ(ΛΑ_/ΛΑ_#), ΛΑ_=Α2-A1.   Prepare buffer:   In a clean glass container, first add HEPES buffer (Good's buffer, zwitterionic buffer, including HEPES, Tris, MES, MOPS, etc.) that has been weighed according to the formula ratio, add appropriate amount of water, and then add surfactant 5ml/ L TritonX-100, use concentrated hydrochloric acid to adjust the pH to pH 6-9, the amount is about 5ml/L, then stir and filter, and then add distilled water to the obtained filtrate to a quantitative amount.   The method of using TOPS as a chromogen substrate to detect serum or plasma FFA has high accuracy and small measurement error, and it is the most suitable color among the many Trinder's chromogens, which is low in acetyl CoA, high in stability, and large in molar absorption coefficient. original. In addition to TOPS, the chromogen substrates produced by Desheng include TOOS, MAOS, ADPS, etc., which are suitable for the detection of blood sugar and other biochemical indicators.

As a common biological buffer, Tris base is not only widely used as a solvent for nucleic acid and protein, but also one of the main components of protein electrophoresis buffer. In addition, Tris can also produce a variety of cosmetics, chemicals, pesticides, medicine, coating preparation and other products, and is an important intermediate for the preparation of surfactants, vulcanization accelerators, reducing agents and some drugs.   1. Used as medicine: if it is often used in acute metabolic and respiratory acidemia, Tris base is an amino acid buffer, which can absorb hydrogen ions and correct acidosis.   2. For synthesis: Tris is used to prepare surfactants, vulcanization accelerators and intermediates of some drugs. Because it has three equal hydroxyl groups, it can also be used as a good reducing agent. In the alkaline condition of sodium hydroxide, it can reduce chloroauric acid solution to prepare stable gold nanoparticles. This method is non-toxic and pollution-free, and belongs to green reduction method.   3. Tris as reducing agent: under alkaline condition, gold nanoparticles can be prepared by ultrasonic reduction of chloroauric acid solution without adding other stabilizers. The environmentally friendly and biocompatible gold nanoparticles were synthesized. Gold nanoparticles with different sizes can be prepared by adjusting the experimental conditions.   4. Neutralizer: the most common function of Tris in cosmetics is to adjust pH value (pH value). It can also be used as a neutralizer to neutralize Thickener (carbomer), so as to reduce the sticky feeling, improve the respiratory efficiency of skin cells, and prevent pore blockage. In addition, Tris can be used as an odor regulator in cosmetics containing amine salts to regulate the odor of amine produced by rubbing when applying cosmetics, so as to avoid the release of any residual or persistent odor.   5. Coating preparation: Tris mainly plays the following four roles in the coating preparation process: pH regulator, cross-linking accelerator, polyester coating raw material and phase change core material.   Desheng has 20 years of experience in developing and producing biological buffers, blood collection additives, color reagents and chemiluminescence reagents, and can provide high-quality Tris raw materials. In addition to Tris, HEPES, CAPS, MOPS and PIPES, our company is actively developing new fields, providing nucleic acid detection materials, virus preservation solution and gel free raw materials, Carbomer, and calls for detailed consultation.

With the formation and continuous development of environmental science, a new environmental monitoring technology has emerged. Chemiluminescence analysis is a common analysis method, which is mainly used in modern testing technology in environmental monitoring. According to the intensity or total amount of radiation produced by chemical reaction, the corresponding component content can be determined by chemiluminescence analysis. Chemiluminescence analysis is an independent analytical technology in atmospheric environmental monitoring, which can effectively analyze trace and trace amounts. In China, after years of in-depth research in chemiluminescence analysis. It is proved that this technology has become an important technology in many aspects, such as air pollutants research, atmospheric environment monitoring, etc. Luminol is one of the earliest and most widely used chemiluminescence reagents. The chemiluminescence reaction of luminol needs to be carried out under alkaline conditions. For example, it can be oxidized by some oxidants, and the maximum emission wavelength of luminol is 425nm. Generally, the oxidant used is hydrogen peroxide. Luminol chemiluminescence system has been successfully used to determine the concentrations of SO2, Co, O3, HS and NOx in the air for a long time. In addition, the chemiluminescence reaction between luminol and hydrogen peroxide is very slow in the absence of catalyst, otherwise it is very fast. The most commonly used catalysts are metal ions. In a large concentration range, the higher the concentration of metal ions, the stronger the luminous intensity. Therefore, the chemiluminescence analysis of some metal ions can be carried out. Using this reaction, the organic compounds containing metal ions can be analyzed, achieving high sensitivity. Environmental monitoring involves many kinds of pollutants in the analysis gas, involving a wide range of aspects, so it needs high sensitivity, wide linear range, and the use of fast and simple detection method. Chemiluminescence analysis has its own unique advantages, which can well meet the above requirements and is widely used in atmospheric environmental monitoring. In order to be able to better adapt to atmospheric environmental monitoring, chemiluminescence analysis will have a good prospect in the following aspects. The application research of chemiluminescence in environmental monitoring and analysis has been developing day by day. With the continuous development of chemiluminescence instruments with high degree of automation, sensitivity and selectivity, and the development and launch of commercial monitoring instruments, the application of chemiluminescence in environmental monitoring will be popularized and promoted rapidly.

It is a kind of raw material for color development in the biochemical kit, CAS number: 82692-96-4, with high water solubility, is a stable aniline analog, the pH range of the color process and oxidation reaction is very wide, Suitable for diagnostic testing and biochemical tests.   Application   1. It has several advantages over conventional color-producing reagents in the colorimetric determination of hydrogen peroxide activity.   2. The new Trinder's reagent is stable enough, and can be used in both solution and test assembly line detection system;   3. In the presence of hydrogen peroxide and peroxidase, during the oxidative coupling reaction with 4-aminoantipyrine (4-AA) or 3-methylbenzothiazole sulfone hydrazone (MBTH), very Stable purple or blue dye;   4. The molar absorbance of the dye coupled with MBTH is 1.5-2 times higher than that of the dye coupled with 4-AA;   5. The amount of substrate can be determined by the color development of the oxidative coupling reaction.   Detection method   1. Prepare sample solutions for enzymatic oxidation reactions. The pH range of the buffer should be 5.5-9.5.   2. Use the same buffer to prepare a standard solution containing a known amount of substrate.   3. Add the appropriate unit of oxidase to the sample solution, and then add an equal volume of the detection solution.   4. Incubate the mixture at room temperature or 37°C for 30 minutes to 1 hour.   5. Prepare a standard curve and determine the concentration of the substrate in the sample solution.   Precautions   1. This product needs to be sealed and stored in a dry and cool place, and it needs to be packaged in a dark brown bottle with a better protection against light;   2. ADOS is a white crystalline powder, if the color becomes darker, it may have grown bacteria or partially oxidized, so it cannot be used;   3. ADOS powder may adhere to the wall of the tube when it is dissolved. Use a centrifuge to centrifuge at low speed to reduce product loss;   4. The product has good solubility and can be directly dissolved in deionized water; double distilled water or ultrapure water can be used for higher experimental requirements.

Recently, many customers have called to inquire about the instructions on the use of luminol chemiluminescence reagent. Although Desheng mainly sells luminol powder reagents, it has always been a case of customers’ problems. With the concept of morality-oriented" and "customer-oriented", the relevant product instructions are introduced here, and I hope it will be helpful to our customers.   【expected usage】   It is a luminescent substrate solution suitable for chemiluminescence experiments.   【Inspection principle】   The principle is to apply the basic principles of enzyme-linked immunology-the combination of the high specificity of the antigen-antibody reaction and the high sensitivity of enzyme catalysis, and the use of enzymes to catalyze the chemiluminescence reaction of the substrate to qualitatively or quantify specific substances in tissues or cells .   【Main components】   Substrate Luminescent Solution A (stored in the dark): Luminol, p-iodophenol, Tris-buffer, etc. Substrate luminescent solution B: hydrogen peroxide, Tris-buffer   [Storage conditions and validity period] Storage conditions: Store at 2 to 8°C, away from light. Validity period: 12 months.   【Instructions】   1. After adding the HRP enzyme marker for washing, prepare to add luminol luminescent substrate solution. 2. When using the substrate, add the chemiluminescence substrate solution A and the chemiluminescence substrate solution B in equal volumes. 3. According to the volume of the specific experimental system, add the corresponding amount of mixed substrate solution, and then place it in a dark place at room temperature for 5 minutes. 4. Detect and measure the result (luminescence value RLU).   【Analysis of test results】   1. The result of blank control without HRP-labeled antibody/antigen and negative control should be colorless. The positive control and HRP-labeled antibody/antigen emit blue light. 2. Detect the luminescence value of unknown concentration by drawing a standard curve, and find the concentration of the target substance to be measured corresponding to the standard curve.   【Precautions】   1. Laboratory supplies should be specific to avoid cross-contamination. 2. Avoid direct exposure to strong light during the experiment. 3. For your safety and health, please wear lab coats and disposable gloves for operation.   Luminol is a very important reagent in the chemiluminescence substrate solution. It is used in the color development stage of the chemiluminescence experiment. It can react with the sample and emit blue light. Luminol reagent is not only used for biochemical detection, carboxylic acid and ammonia compound labeling, metal ion detection, but also for criminal investigation blood stain detection, with very high sensitivity. Luminol produced by Desheng is a light yellow powder, which needs to be dissolved in lye when used. It is prepared now and stored away from light.

Tris is known in Chinese as trimethylol aminomethane, aminobutanol, bradykinine, 2-amino-2 - (hydroxymethyl) - 1,3-propanediol. It is a white crystal or powder. It is soluble in ethanol and water, slightly soluble in ethyl acetate and benzene, insoluble in ether and carbon tetrachloride, corrosive to copper and aluminum, and irritating chemicals.   Tris has high buffer capacity, high solubility in water and is inert to many enzyme reactions, which makes Tris a very satisfactory buffer for many biochemical purposes. Generally used to stabilize the reaction system, pH has a strong buffer capacity between 7.5-9.0.   Advantages of Tris buffer: 1. Because Tris base is more basic, we can only use this kind of buffer system to prepare the buffer with a wide range of pH from acidic to alkaline; 2. It has little interference to biochemical process and does not precipitate with calcium, magnesium and heavy metal ions.   Disadvantages of Tris buffer:   1. The pH value of the buffer is greatly affected by the concentration of the solution. When the buffer is diluted ten times, the pH value changes more than 0.1; 2. The temperature effect is large, and the temperature change has a great influence on the pH value of the buffer. The pH value of the buffer at 4 ℃ is 8.4, and the pH value at 37 ℃ is 7.4. The tris HCl buffer prepared at room temperature can not be used for 0-4; 3. It is easy to absorb CO2 in the air, so the prepared buffer should be tightly sealed; 4. This buffer has a certain interference effect on some pH electrodes, so the electrode compatible with tris solution should be used.   Application of Tris buffer:   In the electrophoretic buffer, glycine buffer system is used to stabilize pH value; Tris-HCL buffer system is used to stabilize pH value in gel; it is widely used as solvent for nucleic acid and protein; the low ionic strength characteristic of Tris buffer can also be applied to the formation of intermediate fiber of nematode; EDTA buffer is added into Tris hydrochloric acid buffer to form "TE buffer", which can be used for stabilization and storage of DNA. The "Tae buffer" can be obtained by changing the acid solution of pH value into acetic acid, and the "tbe buffer" can be obtained by changing it into boric acid. These two solutions were used for electrophoresis.

Climbazole, CAS No: 38083-17-9, EC No: 253-775-4, English Name: clibazole, molecular formula: c15h17cln2o2, relative molecular weight: 292.76, is the most widely used second-generation anti dandruff agent developed by Bayer in 1977. It has broad-spectrum bactericidal properties. It is mainly used in anti itching and anti dandruff conditioning shampoo and hair care shampoo. It can also be used in antibacterial soap, shower gel, medicated toothpaste, mouthwash, etc.   The production of dandruff is caused by external and internal factors. The external factors are mainly affected by microorganisms (bacteria and molds). The effects of light, lipid peroxide and other stimulants produced by oxidation in the air, and various stimulants caused by environmental pollution accelerate the keratinization process of epidermal cells. The internal factors are mainly due to the body's nutritional status, excessive sebum secretion hormone or slightly nervous and other factors causing excessive dandruff. Climbazole has a unique antibacterial effect, especially on the oval dandruff, Candida albicans and other fungi. Climbazole powder Climbazole can block the production of dandruff through sterilization, inhibition of lipase, antioxidation and separation of oxides, So as to achieve the effect of effective anti dandruff, anti itching and hair care. It is different from simply eliminating dandruff temporarily by sterilization and degreasing. In a longer period of time, it can thoroughly protect the scalp and make the hair grow healthily. Therefore, it is welcomed by consumers. At present, active gambosol is widely used in Europe and the United States, in a variety of shampoo and conditioner, because of its inhibitory effect on Candida albicans, it is also used in medicated toothpaste, and has curative effect on gingivitis and oral endometritis.   Dandruff is like dirty things on clothes. It's not a serious disease, but it can make you embarrassed and irritable, and sometimes it can affect external communication. For dandruff, it is unnecessary to go to the hospital (unless there are symptoms such as redness, swelling or severe itching of the scalp). Most people choose anti dandruff hair products to solve the problem. In the hair products, Climbazole is the mainstream in today's market, which can also be called clomiprazole. Although Climbazole alone has limited anti dandruff ability, it can often achieve the best effect with ZPT, and is deeply consumed by the majority of consumers I love it.