China Wuhan Desheng Biochemical Technology Co., Ltd Company News

The new coronavirus is the most terrible word in 2020. There is no doubt that in order to eliminate the fear it brings us, the world is making suggestions for virus detection. Fortunately, with the efforts of scientific researchers, nucleic acid detection is basically Virus carriers have been successfully screened, and methods are needed to have products. In the process of sending nucleic acid samples to be tested, they also need the help of virus transportation media, otherwise the virus nucleic acid will not be detected and will increase. The false negative rate is the so-called missed diagnosis.   There are two commonly used virus transportation media, that is inactivated and activated type. The activated virus transportation media is often infectious due to the virus, which requires very high operating environment and personnel. Once the specimen is contaminated, it will cause unpredictable consequences. In the routine virus nucleic acid detection, if the detection environment does not meet the requirements, it is recommended to use inactivated virus transportation media.   The high concentration of guanidine salt in the inactivated transportation media can quickly inactivate and preserve the respiratory pathogens, making the sample lose its infectivity. Virus DNA/RNA extraction kits can be used for inactivated samples. The M32/M96 nucleic acid extraction instrument can quickly extract nucleic acids. At the same time, it can be used with the respiratory pathogen PCR detection kit to achieve rapid detection. The specific sensitivity is not affected.   Features of inactivated virus transportation media produced by Hubei New Desheng: 1. Easy to use and operate, no liquid preparation is required, and the system contains high-efficiency virus lysate. The virus is inactivated immediately after sampling, effectively preventing the risk of secondary infection and ensuring the safety of transportation and testing personnel; 2. Viral DNA/RNA can be stored and transported at room temperature for 1 week without degradation. After extraction according to most commercial kits, the obtained DNA/RNA has good quality and high yield, and can complete various genetic testing and analysis experiments. Such as PCR, qPCR, etc., while saving transportation costs; 3. Nucleic acid RNase inhibitor is included to maximize the protection of viral nucleic acid from degradation and greatly improve the efficiency of nucleic acid extraction. 4. It is suitable for the collection, storage and transportation of common virus samples such as new coronavirus, influenza virus, hand-foot-mouth virus, etc. It can collect pharyngeal swab nasal test samples or tissue samples of specific parts.   Hubei New Desheng now provides a large number of inactivated and activated virus transportation media for domestic institutions or enterprises to meet the needs of nucleic acid testing.  

For a long time, virus infection has been affecting human health, and is also one of the main reasons leading to the pandemic of infectious diseases, just like the current global spread of the new coronavirus. Therefore, the research on viruses has become the focus of the current health field. The extraction and cultivation of viruses, and even the detection and identification of viruses have become the top priority of current research tasks.   In the current technology, the design of common virus transportation media, or the protection of nucleic acids, will point to the protection of viral functional proteins. For example, the virus transpotation media for nucleic acids usually contains the inhibitory effect of dnase / rnase and other functional enzymes, destroying functional proteins, and the virus transportation media that mainly protects functional proteins is not good for the protection of nucleic acids. The first type virus transpotation buffer is more suitable for PCR method or other molecular detection methods, while the second type virus transpotation buffer is more suitable for detection of viral antigens or antibodies, such as elisa or colloidal gold, fluorescence and other rapid detection usage of.   The components of the virus transpotation media currently studied are mainly Hank's liquid foundation. On the basis of Hank's liquid, Hubei New Desheng Materials Technology Co., Ltd. has also added such as gentamicin, fungal antibiotics, BSA (bovine serum albumin fifth group Points), biological buffers HEPES buffer, amino acids, cryoprotectants, glycerin and other ingredients: 1. Gentamicin, fungal antibiotics: a combination of multiple antibiotics, with anti-bacterial and anti-fungal effects; 2. BSA (V): As a protein stabilizer, bovine serum albumin (BSA) can form a protective film in the protein shell of the virus, making it difficult to decompose, ensure the integrity of the virus, and improve the separation rate; 3. Biological buffer HEPES and amino acids: The neutral environment constructed by the buffer helps increase the survival time and infection stability of the virus. 4. Cryoprotectant: Usually the virus transportation media needs to be stored at -70℃. Cryoprotectant can better protect the integrity of the virus.   This virus transportation media can maintain the activity of the virus in a wider temperature range. It has a better ability to maintain the integrity of the virus than Hank's solution. The positive rate of PCR detection and virus separation is higher than the traditional Hank's solution. It can be used for Collection and transportation of clinical specimens such as clinical influenza, avian influenza (such as H7N9), hand, foot and mouth disease, measles and other viral specimens and specimens of mycoplasma, ureaplasma, chlamydia.

Carbomer 940 can be said to be a very classic Carbomer material. The appearance is white loose powder. It is very hygroscopic. It is used as a thickener, emulsifier, suspending agent for various daily chemical, skin care, medicinal. In accessories such as gel emulsion products. Most people may not understand its specific ingredients, this article will briefly introduce.   Carbomer 940, like other carbomers, is a copolymer of polyalkyl sucrose or polyalkyl pentaerythritol and acrylic acid cross-linked polymer. Because it is a polymer, its composition actually refers to the monomer before it is polymerized The composition is acrylic or acrylate. In the dry powder state, the carbon chains of individual acrylic molecules are relatively tightly aggregated, but after being easily dissolved in water, the molecules will gradually disperse, forming hydrated molecules with water molecules, so that the tight carbon chains are dispersed, so the viscosity of the entire dispersion system Also began to increase. The greater the degree of carbomer molecule development, the greater the viscosity. Usually, a neutralizing agent such as sodium hydroxide or organic amine is added to make it fully stretched. Carbomer molecular structure On the other hand, in the composition of carbomer 940, each acrylic acid has an acidic group, which is weaker than acetic acid and has a pH of 2.5-3.5 when dissolved in water. The higher the carbomer concentration, the higher the carboxyl group concentration. The higher the pH, the lower. Pom is easy to generate salts, and when neutralized with alkali, a large amount of ionized carboxyl groups generate negative charges, which will form a repulsive force with each other and make their molecules stretch more. When neutralized to a pH value of 5-9, the carbomer molecule can swell 1000 times and the diameter increases 10 times, the thickening performance is much higher than other thickeners.   When the Carbomer 940 is used, due to its high performance, the amount of addition is very small, usually only 0.2% -1%. In some cases, it will be slightly higher. Generally, the amount of emulsion added is less, and the amount of addition when made into gel Relatively more. When the carbomer is dissolved with polyhydric alcohol or polyethyl solvent without water, hydrogen bonds generated by the carbomer molecule and the solvent can be generated without adding a neutralizer, resulting in strong thickening and suspending properties.

Carbomer 940 is a highly hydrophilic anionic polymer. It is a white loose powder with strong hygroscopicity. It can quickly swell in water, but it does not dissolve. The aqueous dispersion solution is acidic, the pH value of the 1% aqueous dispersion is about 2.5~3.5, and the viscosity is low. When neutralized with alkali, as the macromolecules gradually dissolve, the viscosity also gradually rises, forming a clear solution at low concentrations, and forming a translucent gel at high concentrations. When the pH is 6.5～7, the viscosity and consistency are the largest. When the aqueous dispersion solution of the polymer gel is neutralized with alkali, a transparent and stable gel is formed.   In general, about 1.35g of triethanolamine is required to neutralize 1g of polymer glue. Avoiding compatibility with raw materials such as salts or acidic substances will reduce its viscosity. It is stable within pH 4~10. Triethanolamine (Triethanolamine) is an alkalizing agent, used to adjust the pH value of the product, avoiding the combination with nitrosating agent. The maximum use concentration is 2.5%. Avoid using it in the same formula with formaldehyde as a preservative, which may cause skin irritation and sensitive reactions.   Precautions: 1) Never add some reagents at will! Such as soluble salts, VC, very acidic solutions (lemonade, vinegar). Adding it in, the Carbomer 940 gel system thins out immediately,   2) Although hyaluronic acid is also acidic, it has little effect on the stability of the Carbomer 940 gel system due to the small amount added, so it can be added with confidence. Similarly, pure dew is slightly acidic and has little effect after addition.   3) Carbomer 940 itself is not nutritious and does not support the growth of bacteria and molds, but it cannot prevent bacteria and molds from using nutrients present in the gel system. So don't mix too much at a time, of course, you can also add a little bit of preservative or essential oil as needed.   4) Ultraviolet rays have a certain effect on the Carbomer 940 gel system, so it should be kept away from light.   5) When matching skin care products, the final concentration of carbomer 940 should be controlled within 0.8%. It is recommended to be about 0.5%. If the concentration is greater than 0.8%, it is easy to form a film and the skin feels bad. (Personally suggest that 0.7 or so is more beautiful, if it is too thin, it is close to a thicker liquid.)   Desheng Technology is committed to the development, production and sales of Carbomer 940 and Carbomer980 series products. In terms of carbomer materials, it has formed independent intellectual property rights and professional production research and development capabilities, and has provided product and raw material solutions for more than 100 domestic and foreign manufacturers. Welcome enterprise and individul to call for further consultation!  

Carbomer, also known as Carbopol, is an excellent gel matrix after the neutralization of Carbomer, which has important uses such as thickening and suspension. It is widely used in emulsion, cream and gel. There are many types of carbomer. Our common models are carbomer 940 and carbomer 980. In addition, there are many other models. Different types of carbomer resins have different properties, but they also have common points. The appearance is loose white powder, slightly acidic,with a density of 0.21g/cm3, pH value of 0.5% water dispersing system of 2.7-3.5   Common carbomer models are as follows:   1. Carbomer 940: with short fluidity, high viscosity, high clarity, low ion resistance and shear resistance. It applies to skin care emulsion, cream, transparent gel products containing alcohol, transparent skin care gel, hair styling gel, shampoo and shower gel. The recommended dosage is 0.2-1.0%.   2. Carbomer 980: crosslinked polyacrylic acid resin, local administration system. It applies to skin care emulsion, cream, alcohol containing transparent gel products, transparent skin care gel, hair styling gel, shampoo and shower gel. The recommended dosage is 0.2-1.0%.   3. Carbomer 941: With long rheology, low viscosity, high-definition clarity, medium ion resistance and shear resistance. It applies to skin care lotion, cream, transparent skin care gel, hair styling gel (suitable for medium ion formula). The recommended dosage is 0.1-1.5%.   4. Carbomer 676: With short rheology, high viscosity, high-definition clarity, low ion resistance and shear resistance. It applies to sterilization and disinfection of dishwashing agents (such as automatic dishwashing agents), laundry detergents, hard surface cleaners, anti-toxic cleaners, toilet cleaners, car cleaners, solid fuel glue, alkaline batteries. The recommended dosage is 0.2-1. 0%.   5. Carbomer 934: With cross-linked polyacrylic resin, local delivery system, stable at high viscosity. It applies to skin care lotions, creams, opaque gel products, shampoos, shower gels.The recommended dosage is 0.2-1.0%.   6. Carbomer U20: It can replace the traditional Carbopol 934 for cream or lotion, and replace Carbopal 940 and 980 for clear gel.   The dispersion time of various types of Carbomer in water is related to the water temperature and water quality. It is recommended to use deionized water. After dissolving, make a gel and add other ingredients. Carbomer 940, 941, 934, 980, and 981 require about 8 hours of soaking Carbomer 2020 U10 takes about 4 hours to soak, the specific dissolution time is related to the amount of dissolution.   According to the different materials used in polymerization and the degree of polymerization, a variety of medicinal products have been formed. Commonly used are Carbomer 934P, Carbomer 940GE, Carbomer 941GE, Carbomer 980GE, Carbomer 971GE , Carbomer 974P. Among them GE stands for pharmaceutical grade and P stands for oral grade, so carbomer 940GE can be used for external preparations, while carbomer 934P, carbomer 971P and carbomer 974P can be used for oral preparations.   The most sold models of Desheng are Carbomer 940 and Carbomer 980. At present, the test reports of the two products are complete. They are white loose powder in appearance. They have a weak acid odor and form after dissolution with water or ethanol. The gel is transparent and clear. This is one of the standards for testing the quality of a product. At present, there are many orders for these two products. The ordering period is generally one month later. Purchasers in need should order in advance so as not to miss the good opportunity.

Affected by the new coronavirus epidemic, the global demand for disinfectant hand sanitizers is increasing rapidly. Carbomer 940, as a polymer of acrylic acid, is widely used in disinfectant hand sanitizers, lotions, shower gels, shampoos and other daily chemical products. Carbomer 940, an important raw material in disinfectant solution, has a sudden increase in demand. Due to its special molecular structure, it can absorb 400 to 500 times its own weight of water. As the polymer swells, the viscosity of the system increases, and the liquid can be turned into a gel, thereby achieving thickening, suspension and stability. So how does Carbomer 940 dissolve?     Dissolution method of Carbomer 940 Due to the special structure of carbomer resin, it easily swells when it meets water, so it must be set aside to allow it to fully dissolve in the water, otherwise the gel will be easy to join.   1. First add the carbomer 940 weighed in proportion (generally added amount is about 0.3-0.5%) into the beaker, and then wet it with a little alcohol to pre-disperse, then add 80 degrees Celsius water soak, even if not After stirring for 4-6 hours, it basically dissolved completely.   2.Prepare the carbomer 940 solution, and then mix the other components with the carbomer 940 solution and then neutralize it with TEA to a pH within the range of 6-7. Because it is not easy to control the amount of triethanolamine, if the amount is too large, the system will become thinner, so it is recommended to first dilute TEA into a 10% aqueous solution, drop it in a little bit with a dropper, add while stirring, see When the system becomes more and more transparent and the state becomes more and more thick, the PH value is measured, which is basically in this range.   Established in March 2005, Desheng Technology is a high-tech enterprise based on R&D and oriented to sustainable development. Our company is committed to R&D and production of raw materials and intermediates. Desheng not only has a modern clean workshop and advanced production equipment, a professional R&D team, the production process strictly follows the scientific and standardized operation process, but also is equipped with advanced and complete analysis and testing instruments. The whole process is monitored from the purchase of raw materials to the factory to the final product out of the warehouse. The perfect quality inspection and quality assurance system ensure that we deliver stable and high-quality products to the market!

Carbomer 940 can be described as one of the most popular products in the epidemic. Since Carbomer 940 can be widely used in daily necessities, various skin medicines and stomatological medicines, especially in the field of hand-washing disinfection gel, domestic There is a lot of demand, but due to the tight supply of raw materials of most manufacturers, or the long order period of too many orders, they cannot quickly meet the needs of each buyer. Desheng, as one of the manufacturers of carbomer 940, why target customers in a short period of time, and reach a cooperation intention with them, I think there must be many factors.   First of all, Desheng focused on product research and development, and established a professional carbomer series product R&D team at the first time to ensure that the produced products can meet the needs of buyers no matter the appearance, light transmittance, viscosity range and other parameters. Secondly, Desheng provides customers with free sample delivery service to ensure that customers do not have any problems after the trial and then proceed to the next stage of purchase. This greatly shortens the customer's purchase time, and also solves the customer's doubts about product quality.   Desheng guarantees the product content of Carbomer 940 and the accuracy of various parameters. All the parameters are all accurate data obtained by the production R & D department through a series of inspections and experiments. They are provided by the parameter table, which can be compared and verified by the customer. In addition, to ensure that the continuous spot supply within the customer's needs will not affect the normal use of the customer, the company has a quality inspection report of Carbomer 940, and customers can rest assured to buy.   Now, the new crown epidemic is engulfing many domestic and foreign enterprises like a beast of floods. Of course, it also includes biochemical reagent manufacturers. Seeing that many manufacturers have closed down and how to survive in the crisis, this is a big problem. In the current crisis, Desheng, as a professional manufacturer of Carbomer 940, seriously thinks about the status quo, and actively expanding the current hot product business, has achieved a big hit.I believe that with the efforts of all employees of Desheng, we are sure to create more glories.  

At present, due to the continuous epidemic of foreign epidemics, most imported raw materials are restricted, but the related demand is very large. Carbomer 940 is one of them. Many companies in the market are looking for products, and the quality of domestic production is also uneven, so how to judge the quality of carbomer products?   Carbomer 940 is a very common product of Carbomer series. It has good thickening, high transparency, high viscosity and strong suspending ability. It is widely used in skin care lotions, creams, It is used as emulsifier, suspending agent, thickener and gelling agent in transparent gel products. Due to the important role of carbomer in daily chemical products and the extreme shortage of imported raw materials, many domestic manufacturers began to produce carbomer products, but not every product can meet the demand. Refer to the following methods to easily determine the quality of Carbomer 940 products:   1. From the appearance, high-quality carbomer should be white loose powder, or slightly yellowish, if the color is darker, it means that the product is not pure enough to contain color impurities.   2. In terms of hand feel, carbomer 940 should be lighter and looser. Because its molecules are highly polymerized long chains, the molecules are looser. If the product powder is loose and relatively compact, it means that acrylic acid polymerization control Poor, uneven degree of polymerization or different molecular size, etc .; this way the product is relatively poor in shear resistance, gel transparency and thickening.   3. In terms of odor, since carbomer itself is polyacrylic acid or polycarboxyvinyl, containing acidic carboxyl groups, the polymer is also not volatile, and only has a weak acid odor; if the taste is heavier or has other odors, it may be produced Solvent remains during the drying process.   4. From the transparency of the gel, after dissolving with water or ethanol, the gel formed should be transparent and clear, and the gel is uniform. If the gel is turbid and the light transmission is poor, it will seriously affect the use.   The above is the initial method of judging the quality of Carbomer 940 based on the experience of the production and sales process of Desheng. However, in the process of reagent R&D, it is still necessary to make the final judgment through testing and performance in specific products; In addition to the advantages of synthetic technology, our company also strictly conforms to the ISO9001 management system in the production management of the Carbomer series, which also guarantees the long-term stability of product quality!

Carbomer 940 is a polyacrylic acid polymer. The compound usually appears as a white powder with a slight odor. Properties: (jelly type) very short rheology, high transparency, low shear resistance, high yield value (suspension capacity) ), Can be used as thickener and emulsion stabilizer. It is known for being widely used in the cosmetics industry. Widely used in the pharmaceutical industry, personal care and cosmetics industries. The largest proportion is used for personal care and cosmetics, the ratio is about 54%.   Application of carbomer 940 in skin care emulsion Carbomer 940 has the functions of thickening, suspending, stabilizing the system, regulating the release of water and active substances, and has a simple process and good stability. Therefore, it is widely used in skin care emulsions. It is more refreshing because it has these two advantages, making it more popular with skin care lotions and gel products. Most people often pay attention to the translucent effect when choosing skin care products. Carbomer 940 greatly satisfies many people. In this regard, in addition, the skin care lotion it makes is relatively refreshing and very easy to apply. This has become the first choice for many people with greasy skin, and its status in the skin care field cannot be underestimated.   Application of carbomer 940 in pharmacy The application of Carbomer 940 in pharmacy is mainly manifested in the application of gel. It can be applied to all kinds of oral gel and dental gel, and can be developed into a compound gel preparation which is suitable for consistency and has no greasy feeling and easy to smear. This preparation is effective in treating periodontitis, gingivitis and oral mucosal ulcers, and it has a faster effect and can last for a long time.Carbomer 940 gel matrix has good film forming and adhesion. Adding protein coagulant containing formaldehyde, thymol and other desensitizing drugs to the gel matrix can prolong the residence time of the drug in the teeth. Desensitization effect is enhanced.   Nowadays, the epidemic situation of new coronavirus is getting more and more serious, and all industries are deeply affected by the epidemic situation, resulting in our company's original business not being able to develop normally. Production of virus preservation solution, Carbomer 940, Carbomer 980 and other products have obtained a large number of orders as soon as they are on the market. Due to their wide use, they can be used in many fields. Warmly welcome to come to discuss cooperation!

Carbomer 980 and 940 are another polymerized acrylate material newly developed by the company after acrylate separation gel. Because of its good thickening, emulsifying, suspending and good transparency, it is widely used in skin care milk In cosmetics such as cream, hand-washing gel, sunscreen, non-alcohol perfume, hair conditioner, etc.   Carbomer is a white loose powder, slightly acidic, soluble in water to form a gel, and can produce a high-efficiency thickening effect at a very low dosage (conventional dosage 0.2-1%), thus preparing a very good emulsions, creams, gels and transdermal preparations with a wide viscosity range and different rheological properties; the pH is usually 2.5-4.0 according to the concentration, and it is usually necessary to add a neutralizing agent to adjust the pH to near neutral. Different carbomers have slightly different properties. Compared with 940, carbomer 980 has larger polymer molecules. Under different conditions such as concentration, temperature, pH, etc., its viscosity changes and rheological changes behave differently, each of them has different ionic resistance and shear resistance.     In addition to the above physical and chemical differences, Carbomer 980 and 940 also have differences in application, such as in skin care lotions or gels:   1. Carbomer 980 behaves in addition to elasticity under dynamic vibration of stress, carbomer 940 is worse but easier to apply evenly.   2. When the presence or concentration of ions increases, the transparency of carbomer 980 and 940 is very small, but the resistance of carbomer 980 to ions is higher than that of carbomer 940, so carbomer 980 can provide a relatively higher viscosity and yield value when the ions increase.   3. The skin feel caused by different carbomers is different. Carbomer 980 has a slight elasticity when it is initially applied and the skin feels moisturized and smooth. It is suitable for medium or partial formulas that feel rich, and it is not sticky after use; It feels clear and suitable for refreshing formula.   Desheng Technology has 15 years of experience in the research and development and production of raw materials for acrylic polymer systems. The supply of carbomers 980 and 940 is increasing with each passing day, and the blood collection tube separation gel is also exported to many overseas countries. The rich experience in biochemical reagent synthesis research and development has made its own contribution to the process of replacing imported reagents with excellent domestic reagents.

Carbopol, also known as carbomer, is an acrylic cross-linked resin obtained by cross-linking acrylic acid with pentaerythritol and the like. It is a very important rheology modifier. Carbopol after neutralization is an excellent gel matrix with thickening and suspension and other important uses. The process is simple and its stability is good. It is widely used in emulsions, creams and gels.   Carbomer is a white loose powder; it has a characteristic slight odor; it has hygroscopicity and is a medicinal adjuvant. Carbomer is a high molecular polymer of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether. Calculated on dry goods, containing carboxylic acid group (-COOH) should be 56.0% ~ 68.0%. Carbomer discolors with m-diphenol, and is incompatible with phenol, cationic polymers, strong acids, and high-concentration electrolytes. Carbomer's trade name is carbopol, which is divided into 934, 940, 941, etc. according to viscosity.   Carbomer classification:   Carbopol 940: short rheology, high viscosity, high definition clarity, low ion resistance and shear resistance, suitable for gels and creams.   Carbopol 941: long rheology, low viscosity, high-definition clarity, medium ion resistance and shear resistance, suitable for gels and emulsions.   Carbopol 934: cross-linked polyacrylic resin, local delivery system, stable at high viscosity, used in concentrated gels, emulsions, suspensions.   Carbopol 1342: cross-linked polyacrylic resin, local drug delivery system, excellent rheology modifier in the presence of electrolyte, polymerization emulsification.   Carbopol 980: cross-linked polyacrylic resin, topical delivery system, crystal clear gel, water or alcohol solvent.   Carbopol ETD 2020: acrylate/C10-30 alkyl acrylate cross-linked copolymer, long rheology, low viscosity, high-definition clarity, high ionic resistance and shear resistance, suitable for clear gels.   Carbopol AQUA SF-1: liquid, long-rheological, can be formulated into clear formula, has excellent compatibility with various ingredients, acid thickening, can be used in surfactant system.   carbopol Ultrez 21: acrylate/C10-30 alkyl acrylate cross-linked copolymer, short rheology, used in gels, cleaning and cleaning products, high electrolyte products, creams, lotions.   Carbopol Ultrez 20: acrylate/C10-30 alkyl acrylate cross-linked copolymer, long rheology, shampoo, shower gel, cream/lotion, skin care and hair care gel with electrolyte.   Pemulen TR-1: acrylate/C10-30 alkyl acrylate cross-linked copolymer, thickening emulsifier, short rheology, used in creams, lotions.   Pemulen TR-2: acrylate/C10-30 alkyl acrylate cross-linked copolymer, thickening emulsifier, long rheology, used in emulsion.  

TAPS, the full name N-tris (hydroxymethyl) methyl-3-aminopropanesulfonic acid, CAS No. 29915-38-6; molecular weight 243.28; molecular formula: C7H17NO6S; it is white crystalline powder, soluble in water and other organic solvents , pH buffer range 7.7-9.1. Zwitterionic buffers for biochemical research and molecular biology are currently being used more and more widely in biochemistry, chemistry and medicine. It can be used as bio-buffering agents in biochemical diagnostic kits and DNA / RNA extraction kits. And high-end chemical reagents such as PCR diagnostic kits, cell culture must maintain strict pH values, and as a chelating agent for certain metal ions such as erbium, neodymium, etc., suitable for capillary electrophoresis analysis of DNA and DNA dye complexes , Can inhibit the activity of connexin pipeline, use TAPS physiological buffer in various carbonic anhydrase activities, pKa = 8.4.   Molecular Structure:   There are few reports on the synthesis process of TAPS. In 2010, Chen Gui'e and others studied the synthesis method of TAPS in detail. They use trishydroxymethylaminomethane (Tris) and 1,3-propane sultone (1,3-PS) as raw materials to make them react in alcoholic solvents. Specific operation: Weigh equimolar amount of Tris And 1,3-PS, and take an appropriate amount of alcohol solvent into a 250ml three-necked flask with condensing and refluxing, heating with stirring and refluxing; after a period of reaction, stop the reaction; at room temperature, after the reaction After the solution was allowed to stand and cooled to room temperature, it was suction filtered under reduced pressure. The TAPS crude filter cake was washed 2 to 3 times with an appropriate amount of absolute ethanol. The TAPS filter cake was taken out and placed in a vacuum drying oven to dry. stand-by.   In the above synthesis process, the reaction time, different alcohol solvents and the recycling of the reaction solvent have a certain effect on the TAPS yield and purity. The experimental results show that the reaction time is controlled at 6 hours, and the yield is the highest, reaching 70.3%. Continue to extend the reaction time, the yield decreases slightly; for the ethanol, n-propanol, isopropanol and n-butanol reaction solvents investigated, n-butanol The yield and purity of TAPS as the reaction solvent are the highest, 70.3% and 94.36%, respectively; in the reaction process, the recycling of the reaction solvent is beneficial to improve the yield and purity of TAPS.   Desheng has successfully carried out synthesis experiments based on the results of previous research and development. Now it has accumulated many years of production experience. The production of TAPS standards is high. Now the specifications of Desheng TAPS products are shown as follows: Appearance White crystalline powder Content (Ti) ≥99.0% Water insoluble matter ≤0.01% Loss on drying ≤1.0% pH(1% water solution) 4.4-6.0 Absorbance(260nm 0.1Mwater solution) ≤0.04 Absorbance(280nm 0.1Mwater solution) ≤0.02     The Warning and prevention: ◇ When impurities, foreign matters, abnormal odors, colors, severe moisture absorption and the expiration date are exceeded, the use is prohibited. ◇ Do not continue to use when turbidity appears. ◇ This product is a chemical reagent with strong corrosive properties, fasting, and direct touching by hand are prohibited. ◇ When spilled on the skin, rinse with plenty of water. ◇ If it splashes into the eyes, it can be immediately rinsed with a large amount of water. In an emergency, it should be sent to the hospital for treatment immediately.