China Wuhan Desheng Biochemical Technology Co., Ltd Company News

Facial skin care products and sunscreen products account for 65% and 10% respectively of the skin care products retail market. This market is developing very fast with increasingly fierce competition and sophisticated consumers. Consumers who value time have been looking for high-efficiency and multifunctional products.High cost efficiency can not only save money, but also greatly save the time for skin care. The fiercely competitive market drives brands to look for better solutions. Especially popular brands, hope to promote their brand value in their cost-effective and multifunctional products.Carbomer polymers 940 play an important role in the personal care industry.   With different structures, Carbomer polymers 940 can provide functions such as thickening, changing rheological texture, emulsification stabilization, film-forming, regulating skin feel, and improving skin. In order to provide all of the above functions and make it easy to use. Desheng has made this idea a reality, let's take a look at what properties this polymer can bring to your skin care, sunscreen and makeup formulations.Carbomer polymers 940 is an all-in-one functional product for the development of skincare, makeup and sun protection products with broad compatibility, high functionality and a soft, powdery finish.   Features and Benefits: ✔ Has multiple functions ✔ Special skin feel characteristics: soft, powdery after-feel ✔ Emulsifying performance is not affected by HLB value ✔ Only 1% dosage can provide efficient film-forming properties, improve skin barrier and reduce skin moisture loss ✔ Compatible with high levels of metal oxides and clays such as 17% kaolin ✔ Diverse feeling experience ✔ The polymer exhibits a longer Newtonian fluid phase, resulting in a thicker, more homogeneous film on the skin ✔Polymer provides shear thinning properties for good skin spreading. Compounding with co-thickeners can increase yield for good stability.   Precautions ● In order to prevent the product from foaming, the stirring speed should be low speed to prevent the introduction of air. ● Carbomer polymers 940 can be pre-formulated with humectants as dispersions (polyols, etc.). ● Carbopol polymers 940 have the ability of shear thinning, and the longer the shear time is, the slower the viscosity recovery will be, and even cause the permanent loss of viscosity. ● Carbomer polymers 940 is not affected by temperature, does not support the growth of microorganisms and molds, and does not have surfactant properties. ● UV irradiation will cause irreversible loss of viscosity of Carbomer polymers 940 .   Desheng Carbomer polymers 940 can provide the functional of emulsion stability, rheology modification, film formation, toner dispersion, etc. Now the products have been sold all over the world, and have been unanimously praised after testing. If you are looking for direct manufacturer of carbomer , welcome to contact us.

CAPS, also known as 3-cyclohexylaminopropanesulfonic acid, is a biological buffer with white crystals powder in appearance. CAPS can be dissolved in water and the pH buffer range is 8.9-10.3.Its PKA value is 9.6 when the temperature is below 25°C, and the molecular weight is 243.28.The CAS number OF CAPS is 1135-40-6.What Are CAPS Buffer Can Be Applied In?Actually, CAPS has a wide range of applications, including DNA/RNA extraction kits, PCR diagnostic kits, biochemical diagnostic kits, manufacturing welding materials, air conditioning equipment, manufacturing metal lithium, new coatings, and new industrial materials.   In nucleic acid extraction, it can be combined with 3-[(3-cholamidoendyl)dimethylammonium]-1-propanesulfonate (CHAPS), 3-(cyclohexylamino)-2-hydroxy-1- propanesulfonate (CAPSO), and 2-(cyclohexylamino)ethanesulfonate (CHES),together to prepare a solution for nucleic acid hybridization. It can reduce the yield of non-specific hybrids and improve the specificity of nucleic acid hybridization, while maintaining the yield of target hybrid products, which is of great value in the identification of specific pathogens, the diagnosis of genetic disorders, and the analysis of DNA sequences.   CAPS can be used in various environmentally friendly and high-quality waterborne component polyurethane coatings, and can coexist stably with resins containing active DNA (hydroxyl, carboxyl, amine, epoxy, etc.) for a long time at room temperature. The application of CAPS in coatings is widely used by the waterborne coatings market. In addition, CAPS and aliphatic polyisocyanates can react in the presence of tertiary amine neutralizing agents under mild conditions. The resulting sulfonic acid urea derivatives are very good emulsifiers.   CAPS can be used to prepare the running buffer (also known as electrolyte solution) in capillary electrophoresis, and as the end electrolyte to make the electrokinetic pressurized online enrichment and separation of 2-nitrobenzoic acid and 3-nitrobenzoic acid. The CAPS buffer is suitable for running buffers of high molecular weight proteins (greater than 20KD). If it is a low molecular weight protein blotting experiment, combined Tris with Glycine is generally used, and if glycine is excluded by protein sequencing, Tris-Tricine and EDTA is used.   CAPS can also be used in biochemical diagnostic kits, DNA/RNA extraction kits and PCR diagnostic kits, as buffers for enzymatic chemistry and HPLC separation of alkaline drugs. CAPS can be used as a western blot transfer buffer or transfer buffer in the transfer process of protein sequencing. CAPS can also support alkaline phosphatase activity and suppress the growth of aeromonas at pH 105.After dissolving in deionized water and adjusting the pH to 110 , it was used for the purification of fibronectin. In addition, CAPS is also used as an eluent in cation exchange chromatography,as a raw material in manufacturing welding materials for air conditioning equipment. What’s more,It can also be used to make fireworks, used as analytical reagents, heat exchange carriers,etc.   Desheng have been developing and producing biological buffers for many years with rich experience.CAPS is one of our key products sold well in the market,inquiries are welcome if you have any requirements.

Labeling principle of chemiluminescence substrate acridinium ester in diagnostic reagents in chemiluminescence immunoassay, we label the antibody protein with acridine ester at first, so that the analyte can be detected after the immune reaction. In that case,how to label the antibody is very critical.Acridine salts and related compounds have been widely proven to be very useful chemiluminescent labels, surpassing radioisotopes in stability, label specificity, and detection sensitivity.The acridine-NHS ester, also name as acridine succinimide ester, can reacts with the primary amino groups of proteins. Under alkaline conditions, NHS is substituted as a leaving group and the protein forms a stable amide bond with the acridine ester. After the reaction was completed, the excess acridinium salt was removed through a desalting column. In the presence of alkaline hydrogen peroxide, acridine-labeled proteins can emit light without enzymatic catalysis.   Therefore, the addition of the excitation solution causes the reaction system to release photons at about 430 nm immediately, and the protein concentration can be detected by counting the number of photons with a standard luminometer. Because this luminescence process is completed within 2 seconds, the sample must be placed directly in front of the photon detector inside the photometer. Proteins, polypeptides, antibodies, and nucleic acids can all be labeled with acridine esters.   What should be noted for chemiluminescence reagent is dissolving acridine succinimide ester with strictly anhydrousstrictly anhydrous DMF to prevent the acridine ester from being hydrolyzed. And it should be stored in a dry seal at -20°C when not in use.Different from traditional acridine ester,the structure of acridine succinimide ester has been modified to increase the steric hindrance and enhance the hydrolysis resistance.It can be stable at PH buffer solution at room temperature with PH 7.0.   If the acridine carboxylic acid without -NHS, it is necessary to add a condensing agent such as EDCI, etc., in order to have a coupling reaction with an amine group-containing protein. Acridine hydrazide, containing free amino group, is suitable for direct coupling of polysaccharide nucleic acid or protein containing aldehyde group at the end of acridine hydrazide.   Desheng has been developing and producing in vitro diagnostic reagents for blood detection since 2005. It has in-depth research on blood collection tube additives, chromogen substrates (new Trinder's reagents), biological buffers and chemiluminescence reagents. It has a professional R&D team and production equipment. At present, the company's production equipment and production processes are all newly upgraded. Welcome Inquiry.

When it comes to EDTA, many people should have heard of it. Today, I will introduce two potassium salts used as blood coagulants in blood collection tubes.   Dipotassium ethylenediaminetetraacetate, alias: dipotassium EDTA, CAS number is 25102-12-9, molecular weight is 404.46g/mol,and molecular formula is C10H18K2N2O10.Dipotassium EDTA is actually used as an additive in vacuum blood collection tubes, in the preparation of toilet deodorants, as a complexing agent in liquid phase analysis, and in the preparation of metal polishing agents.   Tripotassium ethylenediaminetetraacetate, alias: Tripotassium EDTA, CAS number is : 65501-24-8,molecular weight is 442.54g/mol,and molecular formula is C10H13K3N2O8.The tripotassium EDTA is used for complexing metal ions and separating metals, preparing anticoagulants in anticoagulant tubes; also used in detergents, liquid soaps, shampoos, agricultural chemical sprays Antidote,etc.   Dipotassium EDTA and tripotassium EDTA are both commonly used as anticoagulants in blood collection tubes.The anti-coagulation principle is EDTA chelates calcium ion in the blood to make anti-coagulation effect.Both are white crystalline powders soluble in water and alcohol.   Although both used as blood collection tube anticoagulants,their anticoagulant abilities are different, mainly in the ability to complex calcium ions cause tghe different usage.In 5% aqueous solution,the pH of EDTA-Ka2 is 4.8 ± 1,and EDTA-Ka3 is 7.3 ± 1. The difference is mainly reflected the stability at different pH condition.The PH of EDTA K3 is neutral that won’t affect the PH of blood.At the same time, its ability to complex calcium ions is stronger than that of EDTA K2.Which reflect the anticoagulant effect is better than that of EDTA K2; What’s more,the solubility of EDTA K3 is higher than that of EDTA K2, which sometimes affects the anti-coagulation effect.But if EDTA K3 is used as a liquid additive, it will cause dilution of the sample. All direct test items, such as hemoglobin, red blood cell, white blood cell, and platelet counts, were 1-2% lower than EDTA K2 as an anticoagulant.   It seems that there are advantages and disadvantages to choose EDTA K2 or EDTA K3 as blood collection tube additives.The important thing is to choose the right one for the detection. Hubei New Desheng is a professional manufacturer of blood collection tube additives. We have been producing these for more than ten years with mature production process and excellent technical indicators.We are worthy of your trust!

Carbomer, which contains a variety of cross-linked acrylic polymers and copolymers, is one of the basic ingredients in many daily products, from cosmetic to personal care products to printing inks, paint adhesives and industrial supplies.Since the development and production of carbomer, many industries have relied on carbomer to increase the viscosity of products,form gels,stable emulsions and suspended particles. In addition, it has the characteristics of improving product quality and improving long-term stability of shelf products. Carbomer is also known as the "best friend of formulator's ".   The main component of carbomer is poly acrylic acid,which is synthesized by free-radical precipitation polymerization in organic solvents. The solvent of this process makes monomers, initiators and other additives soluble in the reaction medium, but the reacted polymerization product is insoluble. According to the record, benzene was used as the preferred solvent for the synthesis of carbomers, but it was unfavorable to health and safety concerns.Now alternative solvent systems such as a mixture of ethyl acetate and cyclohexane are used.   Preparation method of carbomer: 1.Dissolve acrylic acid and a small amount of TAPE and potassium carbonate (K2CO3) in ethyl acetate or cyclohexane co-solvent.K2CO3 is added to the acrylic acid to neutralize a small fraction of the acrylic acid groups to help facilitate precipitation of the reacted polymer in the co-solvent system. 2. Heat the mixture to 50°C under a nitrogen atmosphere and slowly add a peroxy initiator such as bis(2-ethylhexyl) peroxydicarbonate to the reaction vessel within 6 hours . 3. With the progress of the polymerization reaction, the insoluble carbomer product is precipitated from the solvent to form a slurry of carbomer particles in the solvent. 4. After the reaction is complete, the carbomer is separated from the slurry and the polymer solids are dried to yield the carbomer product in powder form.   Hubei New Desheng is specialized in carbomer powder likd carbomer 940/980,U20,U2020,etc.Pls feel free to contact us if you have any requirements.

Carbomer is a very viscous thickener that can effectively build viscosity in aqueous systems at lower concentration.Most carbomer can make 10,000–60,000 cP at only 0.5% w/w viscosity, so carbomer is often used as an aqueous thickener in various products. When preparing the carbomer solvent, it should be taken care to disperse the carbomer powder to avoid agglomeration to form granular fish-eyes, resulting in inability to dissolve.   In the preparation of carbomer gel, dispersion is a crucial step, which usually requires the powder to be slowly sprinkled into the dispersion medium and stirred rapidly. For large-scale gel preparation, a powder disperser can be used to assist. Most of the carbomers on the market today are easier to disperse than traditional ones, reducing the complexity of dissolution,and incorporated steric stabilizers that is ethoxylated nonionics with a block or comb configuration during precipitation polymerization surfactant.The finished carbomer is easily soaked when added to an aqueous medium, but hydrates slowly, allowing for a smooth, uniform dispersion of the carbomer.   Because it dissolves slowly by hydration, the powder is usually added to the aqueous medium at first,stand overnight for fully water absorbing.When the gel is prepared by stirring and mixing the next day, it will be easier to achieve good effect. Desheng is a professional manufacturer of carbomer.At present, we have carbomer 940, carbomer 980,carbomer U20,etc.Our average daily mass production of about 3 tons,which guarantee the delivery in time.And we have a professional after-sales team to support. Now you can apply for a sample online for a trial.

The use of virus preservation solution in daily life is not common, and many people have never heard of it. But in the testing center of the hospital, it is an indispensable detection tool. The virus preservation solution sampling tube is used in many experiments. It is not only convenient to use, but also has a wide range of applications. In addition to the current nucleic acid detection of the Covid-19, the collected samples of influenza virus, hand-foot-mouth virus, measles and rubella virus that are seen daily can be stored and transported in a short-term in virus preservation solution.   Specific uses of virus preservation solution as follows. The virus preservation solution can be used for the extraction, transportation and preservation of nucleic acid detection samples. The volume of the preservation solution required for subsequent virus isolation is about 35m or 5m; It is used to transport nasopharyngeal swab samples or samples from specific parts from the sampling point to the testing laboratory for polymerase chain reaction extraction and testing; It is used to preserve nasopharyngeal swab samples or samples from specific parts for necessary cell culture; For sample collection and short-term transportation of avian influenza virus in the external environment, the required volume is about 6ml; For daily testing and sampling of poultry, pigs and other animals, the required liquid volume is about 15m; It is used in rapid detection kits to collect clinical respiratory virus; For collecting clinical samples of Mycoplasma, Chlamydia and Ureaplasma. Hubei New Desheng Material Technology Co., Ltd. is located in Ezhou City, Hubei Province. It is a manufacturer of virus preservation solutions,including inactivated and non-inactivated virus preservation solutions. As an original manufacturer, the daily sales volume can reach 30 Tons.If necessary, please contact us on www.whdsbio.cn .

As the main raw material often used in blood collection tubes for separating serum and blood clots,serum separation gel has to be mentioned. It has good inert properties and can separate serum and blood clots with adjustment of specific gravity. Although serum separation gel has not been used for a long time, the scope of usage is gradually expanding. Desheng Biochemical is an early enterprise in China in the research and development of serum separation gels, and has been committed to a series of research and development and production of blood collection tube additives. So far, it has developed serum separation gels, heparin lithium, heparin sodium, EDTA K2, EDTA K3, sodium citrate, sodium fluoride, potassium oxalate, disodium EDTA, blood coagulant, blood coagulation powder, etc. They are highly praised by customers for both quality and service. Serum Separation Gel is the first product developed and produced by Desheng Biochemical. Up to now, the daily output is stable at about 2-3t.After four generations of research and development of serum separation gel, whether it is appearance or whole system, our serum separation gel can be better adapt to the needs of various enterprises. The specific gravity, viscosity or flow of serum separation gel required by different enterprises are not the same. Most suppliers of serum separation gels cannot provide corresponding services, but Desheng Biochemical can adjustment all of data ! What we rely on are not only our complete R&D team, but a number of partners we supported and cooperated since the beginning of R&D.We have experienced the problems encountered by most companies,so we can find fundamental solutions to all kinds of problems in time,and can solve them faster and better. The two key points for serum separation gel are inertness and specific gravity. The change of any one index may cause problems in the later use of the product. Desheng will continuous test for those need unique index of serum separation gel. Now Desheng has developed PRP separation gel, which is suitable for beauty tubes. We have cooperated with some beauty centrals for five or six years,and always get satisfactions from them. Desheng Biochemical is a professional manufacturer of blood collection tube additive,welcome to inquiry if you have any requirements.

Bicine buffer is dihydroxyethyl glycine, CAS No. 150-25-4. It is a very versatile biological buffer with same excellent buffering performance as Tris.It has gradually replaced traditional phosphate buffered saline in some demanding biochemical tests. Bicine is a slightly acidic amino acid derivative with pH buffer range 7.6-9.0.It’s soluble in water and common organic solvents such as DMF, DMSO, DMAc, etc. Sodium hydroxide is usually added into powdered Bicine to adjust the pH value to meet the PH environment requirements for experiments or testing. If the experimental environment needs to eliminate the interference of sodium ions, potassium hydroxide can be used instead of sodium hydroxide, and then the pH meter can be used to adjust the mixing ratio of Bicine solution and lye solution. The buffering principle of Bicine is similar to the other biological buffers.Bicine is amphoteric, when acid and alkali are added to the reaction system or the pH of the reaction environment changes as the reaction proceeds, it can play a buffering role and maintain the reaction system. It is very important to biochemical detection which involved enzymes or proteins and nucleic acids. The stability and functionality of most organic biomolecules are very sensitive to pH. The molecular structure of Bicine buffer is similar to that of glycine. The hydrogen on the nitrogen atom of the amino group is replaced by two hydroxyethyl groups, which reduces the hydrolysis ability, improves its stability, and maintain the properties of amino acids and aminoethanols that can form gold complex as a single anion.The buffer system configured with Bicine and sodium hydroxide will not participate in the chemical reaction of the reaction system, nor will it interfere with the experimental reaction, and is resistant to chemical action and enzymatic hydrolysis. Desheng is a manufacturer specializing in the production and development of raw materials for biochemical testing and in vitro diagnosis. It has rich experience in blood pretreatment, blood pretreatment and biochemical kits. At present, the mature product series include blood collection tube additives, chromogenic substrate, chemiluminescence reagents and more than ten biological buffers including Bicine.

1.Is TRIS packed by powder or solution type? If a large amount of Tris required, it is more economical for you to prepare solution with tris powder.The Tris made by Desheng is refined powder which can be used to prepare solutions of different proportions, concentrations and pH values according to the requirements, and it can be formulated into different buffer systems with other buffers like HCl, acetic acid, boric acid, glycine, EDTA, etc.   2.Why TRIS is the most frequent choice for buyers who need biological buffer? Because tromethamine Tris has superior performance than phosphate buffer, and the price is much lower than HEPES and PIPES,so the Tris buffer is the preferred choice for biochemical experiments.The pKa value of Tris in solution is 8.1 at 25℃, and the effective PH buffer range is 7.1-9.1, which can satisfy most biochemical experiments.   3.Issues should be paid attention to when purchasing TRIS (CAS77-86-1) First of all, we must ensure sufficient stock supply. In particular, some customers have relatively large demand, reaching the ton level or more. If there is no sufficient stock as support, the production time will affect their purchasing. The second is whether the product quality is reliable and whether the purity meets the requirements. It is very convincing to provide a full range of product testing services according to customer application needs. In addition, a group of professional R&D teams needed to provide a good technical foundation for sustainable development.   4.What other products can be prepared from Tris? We can prepare products related to TRIS according to its molecular structure, such as Bis-Tris, Tricine, TES, TAPS, etc.Their molecular structures all contain Tris,and they are buffers often used in biochemical experiments and molecular biology experiments,RNA hybridization and DNA lysis. Due to the pH of Tris buffers is greatly affected by temperature and concentration, so environmental influences should be considered when configure Tris solution .   Desheng is specialized in producing white Tris powder, its purity as high as 99%.And we can custom datas according to your requirements. Pls contact if you need Tris buffer.

The target of the Covid-19 nucleic acid detection is the nucleic acid gene fragment inside the virus. Nucleic acid preservation solution is to protect viral nucleic acid from rapid degradation in vitro, so as to facilitate nucleic acid sequence amplification for detection purposes. Mainly divided into two categories: inactivated and non-inactivated. Disposable virus sampling tubes are usually divided into two types, non-inactivated type and inactivated type. Different types need to be selected for different detection purposes. So how to choose the two virus sampling tubes?   Inactivated preservation solution The inactivated preservation solution is prepared on the basis of nucleic acid extraction and lysis solution. The main ingredients are balanced salts, chelating agents, guanidine salts, and surfactants. There are two types of inactivated preservation solutions: one is the guanidine salt-containing type, which can quickly and efficiently denature proteins, lyse cells to release nucleic acids, eliminate RNases, stabilize viral nucleic acids, and inactivate viruses.Another is the guanidine salt-free type, which contains surfactants and does not cleave the capsid protein on the surface of the virus, maintaining the integrity of the virus and making it difficult for the virus to survive.   Non-inactivated preservation solution The non-inactivated preservation solution can retain the protein coat of the virus and the viral nucleic acid at the same time, and maintain the originality of the virus sample to the greatest extent. In addition to being used for viral nucleic acid detection, it can also be used for virus culture, etc. However, because the virus has not been inactivated, there is a risk of infection if the operation is wrong. The Second Trial Version Work Manual for Viral Nucleic Acid Detection clearly states that sampling tubes with inactivated preservation solution which containing guanidine isothiocyanate or guanidine hydrochloride or surfactants should be choose for population screening.For rapid testing in fever clinics or emergency departments, the sampling tube shall be determined according to the requirements of the nucleic acid detection reagents used.   Regardless of whether it is an inactivated type or a non-inactivated type, the virus sampling tubes must be strictly inactivated and sterilized before sampling to ensure that there are no other microorganisms which may cause the virus to decompose or other influences causing false detection. After swab sampling, if a collection tool or preservation solution of poor quality is used, it will affect the subsequent test results and even cause misdiagnosis. Therefore, you must choose a virus sampling tube produced by a professionally qualified manufacturer.   Desheng is one of the first companies to invest in the R&D and production of virus preservation solutions since the resumption of work in 2020. At that time, there were little companies joining to produce it. With the increase in the demand for nucleic acid testing, a batch of enterprises that have put into production.No matter at the beginning or now, Desheng always remembers to give back to customers with good quality. Only when the quality is guaranteed, can we gain the trust of more customers. At present, it has obtained the production certificate of Class I medical devices.Samples available for new customers,welcome to inquiry.

In the Covid-19 test, whether it is nucleic acid or antigen, the nasopharyngeal swab after sampling needs to be put into a storage tube with a preservation solution. Are the nucleic acid preservation solution and antigen preservation solution for Covid-19 the same thing?Can it be shared? Nucleic acid testing The target of the Covid-19 nucleic acid detection is the nucleic acid gene fragment inside the virus. Nucleic acid preservation solution is to protect viral nucleic acid from rapid degradation in vitro, so as to facilitate nucleic acid sequence amplification for detection purposes. The main components are balanced salts, chelating agents, guanidine salts, surfactants, etc.   Antigen detection The target of the Covid-19 antigen test is the specific protein on the surface of the virus. The main components of the antigen preservation solution are low ionic strength buffers (such as Tris buffer, PBS buffer, etc.) and surfactants (such as Brij58, Triton X-100, etc.).   Viral nucleic acid preservation solution and antigen preservation solution The main function of the antigen preservation solution is to protect the antigen protein from denaturation or decomposition, and it can react with the gold-labeled specific antibody on the detection test strip. The guanidine salt and other components in the nucleic acid preservation solution will denature the antigen protein, affect the antigen-antibody reaction, and cannot form the antigen-antibody complex, resulting in false negative or invalid results. Therefore, the preservation solution of new coronavirus nucleic acid and antigen cannot be shared.   Preservation solutions from different manufacturers cannot be mixed To sum up, nucleic acid detection preservation solution and antigen detection preservation solution are not the same thing. In addition, the antigen preservation solutions of different manufacturers cannot be mixed, and the components of different brands of products are quite different, and the performance (specificity and sensitivity) of the antigen detection reagents of each manufacturer is related to the pH value of the supporting preservation solution. The specificity and sensitivity of the reagents are optimal when the pH for the antigen-antibody reaction of most chromatography methods is alkaline. When using a non-matching sample preservation solution, the pH value of the reaction environment will change, resulting in false positive or false negative results.   Desheng currently produces inactivated and non-inactivated viral nucleic acid preservation solutions. The daily shipment volume is as high as tens of tons. Generally, the customers who cooperate with us are repurchased stably for a long time, which fully shows that the quality is recognized by the public.No matter whether the customer's demand is large or small, Desheng will arrange production and delivery as soon as possible, even if it is a few tens of tons.If you need virus preservation solution or other blood collection tube reagents, please contact Desheng Company.