China Wuhan Desheng Biochemical Technology Co., Ltd Company News

What to check with heparin lithium anticoagulant tube       Patients often use different colors of blood collection vessels when taking blood samples for examination. Medical staff also use these colors to determine what items the patient is testing. Especially, anticoagulant tubes containing heparin lithium are used more frequently. So what can it be used to check? Many people don't understand this. Let's introduce it to you in detail.       1、 Check for routine liver disease       After collecting blood samples with heparin lithium anticoagulant tube, the patient can be checked with analytical instrument to see whether they have liver diseases, such as hepatitis, nephritis or liver cancer, which can ensure that medical staff can effectively eliminate or prevent diseases from the examination results, so that the patient can receive timely treatment. Note that heparin lithium is not a test item, but is responsible for preventing blood coagulation and improving efficiency.       2、 Check ESR and blood gas       Due to the presence of heparin lithium in the anticoagulant tube, heparin can interfere with the whole coagulation process, play the role of antithrombin, and promote the blood coagulation time of the sample to be extended, so it is very suitable for blood gas analysis, examination of erythrocyte sedimentation rate and other items, but it should not be used to check blood coagulation.       3、 Check electrolyte       Although heparin sodium anticoagulant tube was selected for electrolyte determination in the early stage, it was found that there was some influence. Later, after technical improvement, it was slowly replaced with heparin lithium tube for blood potassium examination, and the upper plasma was taken for examination after centrifugation and sedimentation. In addition, a few hospitals will use 3ml lithium heparin tubes to check the lead content of children.       4、 For emergency examination       Most emergency centers are patients whose conditions change quickly and need immediate treatment. The use of heparin lithium anticoagulant tubes in emergency examinations is also due to its anticoagulant effect, which can maximize the detection efficiency and ensure that emergency patients will not miss the best treatment opportunity.       Desheng Biochemistry, as a professional supplier of raw materials for blood collection reagents, has been committed to creating high-quality products. It can put customers' needs first in terms of product appearance, performance, supply and price. At present, in the domestic market, serum gel, EDTA potassium salt and heparin salt are all hot selling products, accounting for a large proportion of sales, and are trustworthy partners. If you have any needs, please click the website to consult and purchase!

Lithium heparin formula       In the process of clinical detection, heparin lithium has a very high application value. Because of its low chelating performance and will not interfere with blood components, it will be widely used as a blood treatment reagent in vacuum tubes. Especially in the determination of some special items, heparin lithium is the only reagent that produces the least interference and achieves the desired effect. Since the effect is obvious, what is its formula? Let's give you a detailed introduction.       Lithium heparin formula       Material 1: crude heparin       Material 2: Trypsin       Material 3: deionized water, ammonia water       Material 4: anhydrous ethanol       Material 5: hydrogen peroxide, sodium chloride       Material 6: resin, lithium salt       Configuration steps       1. Dissolution: first, the crude heparin extracted from animal organs needs to be dissolved in deionized water, and then stirred at a constant speed under the state of heat preservation;       2. Trypsin pretreatment: after dissolution, stir vigorously and evenly, heat up, add ammonia, control the PH value in the reaction process, wash the precipitate with anhydrous ethanol, and finally dry under vacuum for standby.       3. Enzymatic hydrolysis: add trypsin into the reaction solution, adjust the PH value, reach a certain temperature for enzymatic hydrolysis, filter, get the filtrate, weigh the filtrate, and collect trypsin.       4. Oxidation: add hydrogen peroxide into the filtrate of the previous step, and continuously adjust the value, and then conduct oxidation to control the PH value;       5. Re-dissolve: add sodium chloride to step 4 and stir to dissolve.       6. Ion exchange: the filtrate obtained after re-dissolution is completed is passed through the column with ion exchange resin, the effluent is collected, lithium salt is added, and the solution is stirred.       7. Filtration to remove salt and water: use nanofiltration membrane to concentrate and collect concentrated solution.       8. Precipitation and drying: precipitate the concentrated solution obtained in the previous step with ethanol, absorb the supernatant above, wash it repeatedly until it becomes hard particles, and then dry it in vacuum, smash it with a ball mill to obtain high-quality heparin lithium.       From the above steps, we can know that the main ingredient of the formula is crude heparin. After preparation, lithium salt products are used for ion exchange to obtain high-quality products. This way not only simplifies the overall operation process, greatly improves production efficiency, but also reduces production costs.       Desheng Biochemistry, as a manufacturer of heparin lithium in China, has gone to the world at present. Both at home and abroad, it has targeted cooperative customers. In terms of biological buffer, luminous reagent and enzyme preparation, it is gradually updating its categories to provide customers with the best quality products and the most preferential prices. If you have any intention, please click the website for consultation!

Effect of heparin lithium on blood       In clinical blood analysis, heparin lithium tube is relatively common and has unique application value, which can prevent blood coagulation after blood collection. For this reason, its impact on blood cannot be underestimated. Many businesses in the market take advantage of the influence of heparin lithium on blood and make it into drugs to prevent or treat thrombotic diseases, or prepare anticoagulant tubes to achieve the purpose of anticoagulation of blood in vitro. Since the effect is obvious, how does it affect blood? Let's give you a detailed introduction.       As an anticoagulant and anticoagulant in vitro, it mainly interferes with the blood coagulation process, and its influence is mainly shown in the following aspects:       1. The composition of thrombin should be controlled from the root, so that prothrombin can be blocked, and coagulation source can be blocked, and thrombin can no longer be formed.   2. At a high concentration, heparin will inhibit the effect of other coagulation factors of the same type, and promote the change of fibrinogen to fibrin.   3. After the above two links are affected, the platelet aggregation can be prevented, causing damage, and the blood coagulation function will fail, so coagulation will not occur naturally, which is also the effect to be achieved in the test experiment.       As a key analytical reagent in blood testing, heparin lithium has very strict requirements. Because there will be refined heparin and crude heparin in the market, it is necessary to ensure that there are no impurities when using it. In order to accurately purify heparin, it is more necessary to ensure the accuracy of key indicators. At the same time, in order to improve the anticoagulation effect during the use, the conventional dosage of 1mL blood corresponds to the use of 15IU-25IU heparin lithium. Remember not to use too much or not add as required.       The choice of high-quality heparin lithium manufacturers is a problem that every purchaser needs to consider. Here we recommend Desheng, as a Chinese manufacturer of blood collection additives, which has invested a lot of money in research and development, set up a testing and quality department, and strictly control each process layer by layer. According to the production indicators established by the company, both quality and output can be completed on time. Now the heparin products produced have been fully sold and can provide one-stop service for customers. We have cooperation experience with many overseas enterprises. If you have any intention, please click the website for details!

Is heparin sodium the same as heparin lithium       From the perspective of application, heparin lithium and heparin sodium can prevent blood coagulation. They are commonly used products in blood analysis in hospitals. Their appearance and color are the same. They are white amorphous powder, tasteless, soluble in water and easy to absorb moisture. In terms of the method of use, they are dissolved in distilled water, then prepared into a certain concentration and content of solution, and added to the test tube. However, it should be noted that this does not mean that the two are the same. There is still a big difference in the essence. Let me give you a detailed analysis.       The differences between heparin lithium and heparin sodium should be noted in the following aspects:       1. The white blood cell count results of the same sample are different. From the experiment, we can see that the change of heparin sodium is more regular. It will gradually increase with time, and the white blood cell count will increase slowly, and then decrease slowly after 2 hours. However, the measured value of heparin lithium changes little, and is slow and stable, so the final results of the two are also different.       2. The binding ions of the two are different. Although the anticoagulation mechanism is similar and the use is the same, they are also the same form of existence, but one is sodium ion and the other is lithium ion, which are fundamentally different.       3. In whole blood cell analysis, heparin sodium is generally not used, but heparin lithium, which can complete the analysis and test in a short time, but heparin sodium can not achieve such effect.       4. The recommended dosage of the two in the vacuum tube is different. Generally, 9.4IU-28IU of heparin lithium will be added to every milliliter of blood, while the dosage of heparin sodium is 12IU-30IU.       5. The price is different. Based on the use of the two and the replacement of heparin lithium with heparin sodium, the price of heparin lithium is higher than that of heparin sodium. In addition, heparin sodium sometimes affects some test experiments, while heparin lithium does not.       Desheng, as a manufacturer specializing in the production of blood collection additives in China, all products are independently developed, not only have a quality assurance system, but also have strict control and supervision by professionals. At present, there is a large amount of stock supply in the warehouse, which can be shipped on the same day. The conventional potency of heparin sodium and heparin lithium is between 150IU-180IU, packed in 10g, 50g/bottle, or sub-packed according to customer requirements. If you are interested in purchasing, please click the website for details to order!

What effect does heparin lithium have on blood       In the blood test, the appearance of heparin reagent makes the test simple and fast, mainly heparin lithium, which can fully prevent blood clotting inside the test tube. At the same time, due to its small chelating property and low positive ion concentration, heparin lithium will be used for determination in blood or plasma detection, so that heparin lithium can also play the greatest role in blood. Let me give you a detailed analysis.       1、 Performance and principle of heparin lithium       As a reagent to prevent blood clotting, its appearance color is white powder, tasteless, soluble in water. Because it is suitable for clinical biochemical examination, there are strict requirements for extracting high-quality serum. Its working principle is to inhibit the aggregation of platelets, inactivate thrombin, strengthen antithrombin, fully ensure that blood does not coagulate, and plasma centrifugation speed is faster.       2、 Effect on blood     To understand the effect of heparin lithium on blood, we must understand its effect and process on blood coagulation. Thrombin plays a great role in the whole process, and can prevent blood coagulation through it. This is because the blood contains fibrin, platelets and other substances, and platelets have coagulation effect. Heparin lithium controls platelets from the source, making coagulation factors unable to participate in the coagulation process, inhibiting these coagulation factors to play a normal role, thus preventing blood coagulation and achieving clinical purposes.       3、 Determination of heparin lithium       In the clinical determination of ion content, because it will not affect the determination of ion, only heparin lithium is the most qualified product in the heparin type, which basically does not contain excess ions and has faster anticoagulation effect. It is also the main reagent used in this determination experiment.       It can be seen from the above that heparin lithium mainly plays an anti-coagulation role in blood. Although some heparin can be prepared into drugs or directly injected into human body on the market, it is achieved through blood. As a professional supplier of heparin lithium in China, Desheng produces and sells heparin products, which are mainly used for anticoagulation in vitro and not for other purposes. This needs to be understood clearly. At the same time, the potency of heparin lithium sold is between 150IU-180IU. If you are interested in purchasing, you can click on the website for consultation to indicate your needs in advance and obtain more accurate quotations.

Who produces heparin sodium       As an anticoagulant in routine blood testing, heparin sodium can inhibit coagulation factors due to its chelating property to prevent thrombin from coagulation or activation, thus effectively preventing blood coagulation, and is applicable to PH measurement and blood gas analysis. Although it is a commonly used anticoagulant, there are not many manufacturers in China that can really make heparin sodium. Who is the best manufacturer of heparin sodium?       Here, I would like to recommend Hubei Xindesheng, a manufacturer dedicated to the R&D and production of heparin sodium. It has invested a lot of effort in the R&D of heparin sodium products, strictly controlled the stability and consistency of product quality, and also completed it as the core element and goal of quality control. As a high-quality heparin sodium manufacturer in China, its advantages are obvious. Here are the highlights.       1、 The quality parameters are strictly controlled and meet the requirements       When high-quality heparin sodium products are added to the vacuum test tube and used as an anticoagulant in vitro, it is necessary to ensure that the PH value range is between 6.0-8.0, the average molecular weight reaches 15000, and the potency and water system have good solubility. Observe whether it is pure and free of any impurities. Desheng strictly controls these values and has met the requirements. As an anticoagulant, its performance is stable without any adverse effects.       2、 Sufficient stock in warehouse       Desheng is a manufacturer of heparin sodium in China and has an independent warehouse. After the equipment upgrade and transformation, the output is high, which can ensure the sufficient supply of goods. In the face of large demand customers, it can also ship goods from the warehouse in time, and there will be no shortage of goods. Therefore, it can choose boldly and confidently.       3、 Perfect after-sales service guarantee       After-sales service is closely related to customers' demand. Many customers prefer to spend more money to choose a manufacturer with perfect after-sales service, so that they can use the product with ease after purchasing. Desheng is equipped with a professional after-sales team to solve customer problems one-on-one. Once there is a problem with the product, it will return and replace the product at the first time, and will not hesitate. It is a trustworthy manufacturer.       4、 Preparation process of heparin sodium       As an anticoagulant in vitro, heparin sodium is usually manufactured in powder form, which requires accurate purification in the purification process to ensure that it is high-quality heparin sodium, so it can be safely used. In this process, it is necessary to ensure that the extraction process is stable, simple and efficient. Desheng has developed a new extraction method, which can fully guarantee the quality of heparin sodium extracted, and the product qualification rate is high, so it is a manufacturer worth choosing.       From the above four aspects, we can see the advantages of Desheng in the production of heparin sodium. If you also have relevant needs, please click the website for details! Desheng makes every effort to serve you.

There are many neatly arranged test tubes in front of the laboratory window of the hospital, but not all of these test tubes are exactly the same, and their sizes and colors of caps are all different. Why is it prepared in this way? What exactly does it do? In fact, this is mainly because the additives inside the test tubes are different, and the inspection items are also different. Heparin sodium tubes are one of them which commonly used in clinical practice.   The cap of vacuum tube containing heparin sodium is usually green, because it has the function of preventing blood coagulation and prolonging the coagulation time of blood samples, so it is suitable for red blood cell fragility test, blood gas analysis, hematocrit test, erythrocyte sedimentation rate and general biochemical test. 1. Routine blood test and collection The heparin sodium test tube can be used to check blood, collect plasma, and prevent blood coagulation, so that medical staff can separate plasma from blood during biochemical examination. In addition, blood tests can also be used to determine whether a patient suffers from liver disease, such as liver function decline, liver cancer, fatty liver, etc.What’s more, it and can effectively rule out the possibility of suffering from such diseases.   2. Biochemical examination As a professional anticoagulant tube, the heparin sodium green vacuum tube was used as a way to measure electrolytes in the early days, but later it was found that there may be some problems with the test results. After technical improvement, it will gradually be used for the inspection of the upper plasma after centrifugation.   3. Routine plasma biochemical determination The heparin sodium tube can be used together with serum separation gel, which can not only prevent blood coagulation, but also promote rapid separation of blood and ensure the accuracy of test results, so it is suitable for routine plasma biochemical assays and emergency plasma biochemical assays such as ICU .   However, it should be noted that the application of heparin test tubes in medicine is completed by supporting analytical instruments. The main function is to anticoagulate blood outside the body, and it is not directly used in the human body. Everyone needs to be clear about this. As a manufacturer specializing in the production of blood collection tube reagents in China, Desheng is highly recognized by many customers in the domestic market. Due to the full range of products, we can provide you with one-stop purchasing service, equipped with a professional service team for all of your questions immediately without delay. If you have requirements for blood collection tube reagents, please click the website for details.

Which test is lithium heparin used for? In the work of blood analysis in hospitals, the use of heparin tubes is relatively common. Because of its low chelation performance, strong stability, and no impact on blood components, its application value has been valued by the medical field. In particular, the use of heparin lithium as an anticoagulant has become a necessary reagent in the collection and testing of whole blood samples. However, in addition to blood collection, it can also be used for clinical testing. Let me introduce it in detail below.   1. For biochemical detection of patients after hemodialysis   In the laboratory department, there is a test that is very troublesome for medical staff, that is, the patient's sample after hemodialysis. It is not easy to coagulate, and the separation of serum is also difficult. If a lithium heparin tube is used for collection and anticoagulation, since it will not interfere with the cell volume and is not easy to cause hemolysis, it can be centrifuged directly without using a water bath. After heparin lithium prevents blood coagulation, the plasma obtained after separation is closer to the real test results of the human body. Medical staff can make accurate judgments on the patient's condition by establishing a plasma biochemical test reference value system.   2. For routine biochemical detection   In recent years, another form of heparin has been favored by routine biochemical testing items, and has also become one of the important ways to judge the disease and prevent diseases, that is, lithium heparin anticoagulant plasma replaces serum, but at this time it needs to Potassium ion concentration, blood sodium, etc. establish a reference range. However, it should also be noted that in some other projects, such as pulmonary artery, hydroxybutyrate dehydrogenase, lactate dehydrogenase and other biochemical projects, this method is not suitable for detection, and it may increase with the increase of heparin concentration.   As a professional manufacturer of blood collection tube additives in China, Desheng produces lithium heparin with a stable process and pure appearance, with an average molecular weight of 15,000, which can highly meet the needs of customers. However, we need to remind everyone that the heparin series products currently produced by Desheng are mainly used as anticoagulants in blood collection tubes, not injection grade or drugs for human body. If you have relevant needs, please click on the official website or call for consultation! It can be customized according to your different requirements, and the price is favorable for large quantities. Your purchase is welcome.

        Usage of Green cap-- Heparin Lithium Tube   The green lithium heparin tube literally means that lithium heparin is added to the disposable closed blood collection tube, which has the function of affecting the coagulation process and preventing platelet aggregation. At the same time, because the blood sample is collected in a closed test tube, the plasma precipitation speed is guaranteed, the time for manual plasma separation is reduced to a certain extent, and it is not easy to be contaminated, which improves the detection efficiency. Although it is more commonly used in clinical practice, there are still a few people who do not know the precautions for its use, so the following will focus on introducing it to you.   Use of green heparin lithium tube:   1. Due to the special performance of lithium heparin, both the chelating property and the concentration of cations are relatively low. If it needs to be used in blood or plasma testing, chemical measurement is recommended. Also, because lithium heparin does not contain any form of ion, it is not suitable for testing blood for lithium.   2. In order to promote the full anticoagulation of blood during use, the test tube should be slowly inverted and mixed 5-8 times immediately after blood collection, especially when the temperature of the blood collection environment is above 25 degrees, the blood must be mixed with heparin lithium in time, otherwise Easy to cause local coagulation.   3. Heparin anticoagulation is non-irreversible anticoagulation. During use, pay attention to complete the test in a short time. The ideal time is 6 hours. Do not leave it for too long, which will easily lead to deviations in the test results.   4. The separation gel is usually added to the test tube and used together. Pay attention to the quality of the separation gel, which may affect the blood separation effect. It is recommended to use products from the same company, which can ensure the accuracy of the plasma sample data.   5. After the test tube is prepared, it should be sterilized by irradiation. It is recommended to use γ-ray irradiation with a dose of 8-25kGy. The irradiation dose can be determined according to the initial number of colonies.   6. It is forbidden to use when impurities, foreign matter, abnormal color appear in the test tube and the expiration date is exceeded.   The above are the precautions for the use of green lithium heparin tubes. As a clinically necessary reagent product, quality requirements should be guaranteed, and the accuracy of use should be guaranteed to a certain extent, so everyone should also pay attention to it. As a Chinese manufacturer of raw materials for blood collection tube additives, Desheng has been committed to strictly controlling product quality, and has set up a quality department to repeatedly test the products that leave the factory. In recent years, it has been deeply recognized by the domestic market, and foreign cooperative customers are also increasing. If you have relevant needs, please click the website to consult details!

How heparin lithium works as an anticoagulant       In clinical work, the treatment after collecting blood samples is one of the important detection steps. Its treatment methods include anticoagulation and coagulation promotion, so that the processed blood samples can meet the requirements of various biochemical detection items in clinical practice. Among them, anticoagulant reagents include heparin, potassium EDTA, potassium oxalate, etc. Although they have the same effect, their working principles are fundamentally different, especially the working principles of heparin. Next, we will focus on how heparin lithium works as an anticoagulant.       Heparin-like anticoagulants mainly include heparin lithium and heparin sodium. However, compared with the two, heparin lithium will have more advantages, and its price will naturally be more expensive than heparin sodium. However, it will be better in terms of anticoagulant performance and widely used, so it is also considered as an ideal anticoagulant in blood testing.       As an anticoagulant, its working principle is mainly realized by affecting the coagulation process:       1. First, the activity of antithrombin is increased by controlling the formation of prothrombin activator.       2. Heparin and antithrombin 3 combine to form a revivant, while AT - Ⅲ is a serine protease inhibitor, which can inactivate coagulation factors XII a, XI a and X a with serine protease activity.       3. At the same time, because it accelerates the inactivation of coagulation factors, it can affect thrombin, and heparin can prevent platelet adhesion and aggregation, thus preventing platelet decomposition and releasing platelet factor 3 and serotonin.       4. The structure of antithrombin has changed, so these coagulation factors can not participate in the coagulation process, and inhibit these coagulation factors to play a normal role, so as to achieve the purpose of anticoagulation.       From the above points, the main working principle of heparin lithium as an anticoagulant is to influence the coagulation process, so as to prevent blood coagulation from the source and achieve the purpose of clinical experiment.       Desheng, as a manufacturer specializing in the production of raw materials for blood collection additives in China, not only has 18 years of experience in research and development and production, but also has strict control over product quality. The raw materials for blood collection sold in China are widely recognized and praised. The conventional potency of heparin lithium produced by the company is 160IU/mg, which can also be customized according to customer requirements. If you need, please click the website for details!

Dark green lithium heparin tube       As a natural ideal anticoagulant, heparin lithium is often added to dark green test tubes to prevent blood coagulation. Generally, the quality of heparin lithium is determined by its potency. The common potencies are 150IU, 160IU, 170IU and 180IU. The higher the potency, the higher the quality and price of heparin lithium will be. Next, we will introduce the application of dark green lithium heparin tube and the precautions for use.  

Recently, Desheng has been receiving inquiry about heparin sodium, and the quote is too different from the market. It is normal to have such emotions, because the price of heparin sodium is related to type and quality. Let me introduce the price of heparin sodium in detail below.   Heparin was mainly extracted from animal organs in the early days, and later research found that some mammalian organs also contained heparin, so it was derived from pig intestines, cattle and sheep and other organs. It has a wide range of uses, such as anticoagulant in blood collection tubes and various thrombotic drugs, etc. The production process of heparin varies from manufacturers, so the use and cost are different, and the price will also be vary naturally.   Different types of heparin sodium 1. Unfractionated heparin sodium: a mixture composed of some chemical substances alternately, usually extracted from pig intestines or bovine lungs, and prepared into drugs for clinical use. Because it is a kind of drug, the price will be higher. 2. Crude heparin sodium is extraction from pig intestines.With elution, filtration, merging of the supernatant and filtrate.Then adding ethanol for precipitation.After carefully drying and sucking out the supernatant, collecting the lower sediment, pumping filter until dry, and then vacuum-dry to produce crude heparin. The requirements and production process of this heparin sodium are relatively low, and its price is also lower. 3. Vacuum blood collection tube anticoagulant heparin sodium.It is mainly used as an additive in vacuum test tubes. As an anticoagulant tube, it can prevent blood samples from coagulating within a certain period of time. This kind of heparin is different from other types and has a relatively high potency. For high-quality heparin sodium, the price gap will be larger.   Differences in origin of heparin sodium For the heparin used in the medical industry, some manufacturers use imported raw materials, and some use domestic raw materials. The difference between imported and domestic products naturally leads to price differences.   Rare sources of heparin Although heparin can be extracted from the organs of mammals such as pigs, cattle, and sheep, these heparins are mainly crude products, and the key extraction site is the small intestine of pigs, but the heparin extracted from pig intestines is very rare, sometimes 3000 pigs can extract 1 kg of heparin. If the pork price fluctuates and adjusts, the price of heparin sodium will also be affected. Therefore, the price adjustment of heparin sodium is related to various factors.   Desheng is a Chinese manufacturer specializing in the production of heparin sodium, which is mainly added to vacuum test tubes for in vitro anticoagulation. The price can be negotiated according to the quantity, and can be customized according to the different needs of customers.If you have any requirements in this regard, welcome to click on the website for consultation!