China Wuhan Desheng Biochemical Technology Co., Ltd Company News

In the era when Chinese cosmetics are moving towards efficacy evaluation, Hubei New Desheng Material Technology Co., Ltd. has opened the reporting authority of cosmetic raw materials HEPES buffer safety-related information on the raw material safety information service platform of the State Drug Administration in accordance with the requirements of the "Evaluation Specification for Cosmetics Efficacy Claims".And we obtained the reporting code. Since then, our company can independently or authorize domestic and foreign customers to evaluate the efficacy claims of the cosmetic raw material HEPES and upload the efficacy basis. Cosmetics are processed from various raw materials with different functions and effects for human skin.So the safety of cosmetic raw materials is very important. HEPES produced by our company is an odorless white powder. Under certain conditions of temperature and pH value, N-hydroxyethylpiperazine reacts with sodium chloroethylsulfonate solution and produces HEPES reaction solution. Crystals precipitated by drying from solution,and get the finished product of HEPES. Although HEPES is a chemical synthetic raw material, it is relatively mild and has no irritating effect on the skin. It is often used in cosmetics for whitening,and repairing.In cosmetics, HEPES not only acts as a PH adjuster to stabilize the PH of cosmetics in a weakly acidic state suitable for human skin, but also prolongs the shelf life of cosmetics. The use of HEPES in cleansing cosmetics can accelerate the softening of the cuticle, promote cell metabolism, shrink pores, and make the skin look fairer and more lustrous; when used in essences and rejuvenating creams, it can promote the absorption of other functional products . Experiments have shown that HEPES also has anti-inflammatory effects, which is a great boon for people with acne-prone skin. Our company has invested a lot of resources in the research and development and production of HEPES,and can produce high-purity HEPES white powder with excellent properties, which you deserve it. Welcome new and frequent customers to inquiry.We can provide you the safety-related information reporting code of cosmetic raw material HEPES.

The principle of Trinder's reaction is also known as enzymatic method.Under the action of peroxidase, hydrogen peroxide, 4-aminotipyrine (4-AAP), a red quinoneimine compound generates for the determination of light absorption,which is one of in vitro diagnostic reagent method.It is mostly used in biochemical diagnostic reagents to detect liver function, kidney function, blood sugar, blood lipids, etc. Trinder's reaction is to mix the corresponding the new Trinder's reagent, 4-AAP, oxidase and peroxidase to the item to be tested in an appropriate ratio, then add biological buffer and the test substance to cause a color reaction.The value of the item to be measured is calculated by measuring the absorbance of the red quinoneimine compound in the color reaction product. The enzyme in the reaction has specificity and can catalyze the reaction of a specific substance in a targeted manner, ensuring the accuracy of the detection. The biological buffer ensures that the reaction is carried out in the appropriate PH value of the corresponding enzyme. Traditional Trinder's reagents are phenols (phenol, 4-chlorophenol or sodium 2,4-dichloro-6-phenolsulfonate, etc.) and anilines (N,N-dialkylaniline, N,N-Dialkyl-m-toluidine,etc). Phenols have a small absorption wavelength range, and the substances in the test may interfere with the test results. Aniline chromogen substrates need to be carried out under acidic conditions, which limits the use of enzymes, so they cannot be widely used in practical detection. Compared with the traditional Trinder's reagent, the new Trinder's reagent has higher water solubility, a wider range of ultraviolet absorption waves of the color reaction product, a wider range of acid-base reaction requirements, and a more sensitive reaction, so it is more practical in biochemical reactions. There are 9 kinds of new Trinder’s reagents independently developed by Desheng, TOOS, TOPS, ADOS, ADPS, ALPS, DAOS, HDAOS, MADB, MAOS, all of which are white crystalline powders with a purity of over 99%. If the content of the item to be tested is little in serum, ALPS, TOOS, TOPS should be used because they are more sensitive to color; if accurate detection is required, MADB, MAOS can be selected, which have higher absorption wavelengths and not easily interfered by other substances; TOOS, ADOS, DAOS color reaction products are stable and not easy to fade; MAOS is suitable for the determination of wavelengths between 550nm-600nm. Desheng is not only a high-quality manufacturer of the above-mentioned the new Trinder’s reagents, our company can also provide raw materials for biological buffers, which provides convenience for your one-stop shopping with more competitive prices. Welcome to inquiry.

Since heparin was discovered, it is still widely used in the prevention and treatment of various thromboembolic diseases due to its rapid onset of action, definite curative effect and reversible anticoagulant effect. However, there are many types of heparin with similar names, such as blood collection tube additive heparin, low molecular weight heparin, enoxaparin, nadroparin, etc., which can easily lead to mutual confusion. What are the types of heparin and what are the differences between each type of heparin? Today Desheng takes you to find out. Heparin is mainly divided into unfractionated heparin (UFH), blood collection tube additive heparin, low molecular weight heparin (LMWH), heparin derivatives (such as fondaparinux sodium), and heparin analogs (such as danaparin). Unfractionated heparin is a mixture of sulfated glycosaminoglycans (GAGs). It is a mucopolysaccharide sulfate alternately composed of D-glucosamine, L-iduronic acid and D-glucuronic acid, which can be prepared from the lungs of cattle or the intestinal mucosa of cattle, sheep and pigs. Vacuum blood collection tube anticoagulant heparin (sodium heparin or lithium heparin) is an additive in blood collection tubes. It is used in anticoagulant tubes to prevent blood coagulation in vitro after blood collection for a certain period of time. This heparin is usually not of injection grade. It is different from heparin drugs, but its potency is relatively high. Heparin for Cosmetic raw material can be added to nutritional creams, eye creams, acne-removing products and hair growth agents, etc. It has many functions like increasing the vascular permeability of the skin,improving local vascular circulation,promoting the supply of skin nutrients and the excretion of metabolic wastes. It Plays a good role in health care and maintenance of the skin. Heparin with low molecular weight is a short-chain preparation obtained from the separation or degradation of unfractionated heparin. Due to differences in molecular size, anticoagulant activity, preparation method, and manufacturer, commonly used clinical heparins with low molecular weight include enoxaparin, dalteparin, and nadroparin. Different molecular weight The molecular weight range of unfractionated heparin is 3000~30000Da, and the average molecular weight is 15000Da, which is equivalent to 45 sugar units. The molecular weight of low molecular weight heparin is about 1/3 of that of unfractionated heparin, and the molecular weight of fondaparinux is the smallest, only 1728Da. The size of the molecular weight is closely related to the anticoagulant activity and mechanism of action of the drug. Different mechanism of function The anticoagulant effect of heparin is mainly mediated by antithrombin III (AT-III). Heparin molecule combines with AT-III lysine residue to form a reversible complex, which changes the AT-III configuration.Then the active site of arginine fully exposed to rapidly bind with the serine active center of IIa (thrombin),IXa, Xa, XIa,etc. It accelerates the inactivation of coagulation factors. When heparin inactivates factor IXa/IIa by AT-III, it must combine with AT-III and coagulation factor to form a ternary complex, while when inactivating by factor Xa, it only needs to combine with AT-III. Once the heparin-AT-III-coagulation factor complex is formed, heparin is dissociated from the complex, combined with another molecule of AT-III for repeated use. Different pharmacokinetic properties Unfractionated heparin can be injected subcutaneously, intravenously or intravenously, but its bioavailability is low during subcutaneous injection, and its elimination in vivo is dose-dependent. In addition, the plasma protein binding rate of unfractionated heparin is as high as 80%, and most of them also bound to endothelial cells, macrophages, etc. That makes its anticoagulant activity unpredictable. Compared with unfractionated heparin, low molecular weight heparin has obvious pharmacokinetic advantages. After subcutaneous injection, the bioavailability of low molecular weight heparin can reach 90%, and the plasma protein binding rate is low, so the anticoagulant effect is more predictable than unfractionated heparin. It should be noted that the heparin currently produced and developed by Desheng (sodium heparin and lithium heparin) is mainly used as anticoagulant in blood collection tubes.It can neither be injected nor used as a medicinal grade. Its potency is relatively high, generally between 150IU-180IU. Of course, a higher potency can be customized. But the higher the potency, the more expensive the price. If you have purchasing requirements, please contact for details!

Luminol, a solution commonly used in crime scene testing, can identify scrubbed or long-lived bloodstains that react with blood to produce a blue glow. Luminol is extremely sensitive and is very suitable for testing the presence or absence of bloodstains in the YES/NO dimension, but it cannot guarantee that it is human blood, and criminal investigation needs to use other means to further characterize it; according to its reaction principle, without considering the premise of interfering substances , the fluorescence intensity of the imprint is proportional to the amount of blood. Fluorescence intensity is not equal to the imaging result. Different exposure parameters and methods can collect different images, but generally you only need to fully expose the reaction results to easily identify the presence/absence, so the fluorescence results you generally see are mostly vague.It doesn't mean better developing means won't lead to better pictures. What is the detected principle of luminol reagent? Its principle is that it will be catalyzed by elements such as metal iron and copper after it’s fused with hydrogen peroxide solution.And the hemoglobin in our human body contains iron.The mixed solution glows blue even encountering very few blood. It has been found that although the DNA in the blood can be destroyed by strong oxidants such as potassium permanganate, the luminol reagent is different. The DNA still can be identified after being dealt with luminol. Hubei New Desheng Material Technology Co., Ltd. is a manufacturer specializing in the production of chemiluminescence reagents,luminol and isoluminol, as well as acridine ester series. You are welcome to consult.

In serum testing, coagulants can be selected to rapidly coagulate blood, while in whole blood or plasma testing, different anticoagulants are selected to prevent coagulation of collected venous blood.What are the commonly used anticoagulants? Hubei Xindesheng Materials Co., Ltd. has compiled some points of anticoagulants for us. The anticoagulation principle of citrate is forming a chelate with calcium ions in the blood to prevent blood coagulation,such as sodium citrate.The color of citrate blood collection tubes are blue or black head.The ratio of anticoagulant to blood in the blue head tube is 1:9 and in the black head tube is 1:4.The blue-headed tube is often used for determinations of blood coagulation,and the black-headed tube is used for erythrocyte sedimentation rate. The anticoagulation principle of EDTA is forming chelate with calcium ions in the blood to prevent blood coagulation such as EDTA-K2.The head of EDTA tubes are in purple.It normally used in blood routine examination, blood cell morphology examination. The anticoagulation principle is oxalate reacts with calcium ions to form calcium oxalate precipitation, thereby preventing blood coagulation. Such as sodium oxalate, ammonium oxalate, etc.The head of oxalate tubes are in gray.It is often mixed with sodium fluoride which can inhibit glucose glycolysis for blood glucose determination. Heparin is a physiological anticoagulant which widely present in human tissues such as liver and lung. It takes effect by enhancing the activity of antithrombin III (AT-III), inactivating serine protease and preventing the formation of thrombin, such as lithium heparin, sodium heparin, etc.The head of heparin tubes are in green.It normally used in various biochemical tests. In addition, Wuhan Desheng Biochemical Technology Co., Ltd. is a professional blood test reagents in research and development, production and sales. We are an established company specializing in the production of anticoagulant raw materials used in blood collection tubes, including sodium heparin, lithium heparin, dipotassium EDTA, tripotassium EDTA, disodium EDTA, potassium oxalate, trisodium citrate, sodium fluoride, etc.Welcome your consultation.

Anticoagulants are preparations added to the blood to prevent blood coagulation by inhibiting the synthesis or function of various coagulation factors exist in the blood. Anticoagulants are commonly used for conditions including deep vein thrombosis, pulmonary embolism, coronary thrombosis, and disseminated intravascular coagulation. The anticoagulant raw materials produced by Desheng mainly include sodium heparin, lithium heparin, ethylenediaminetetraacetate (dipotassium EDTA, tripotassium EDTA, disodium EDTA), which are mainly used in blood collection tubes to store blood.   Sodium heparin, lithium heparin are mainly used to promote the activity of antithrombin III, which inactivates thrombin to prevent blood clotting. The potency of heparin sodium and lithium heparin produced by our company is 150IU/mg, and the potency of anhydrous is 160IU/mg. It is mainly used for in vitro diagnosis and can be adjusted according to customer requirements. Injecting heparin sodium or heparin lithium into the blood collection tubes can be used for anticoagulation of blood samples for emergency biochemical, TORCH, and blood flow detection.   EDTA potassium salt anticoagulant is an amino polyhydroxy acid that can effectively conjugate calcium ions in blood to prevent blood coagulation. EDTA potassium anticoagulant has little effect on the coagulation of blood corpuscles and the morphology of blood cells. The EDTA dipotassium and EDTA tripotassium anticoagulants produced by our company are both used in vitro and cannot be used for injection. They have excellent properties and have a purity of over 99%. Add potassium salt of EDTA into the blood collection tubes, which can be used for general blood routine examination and blood ammonia detection, but cannot be used for blood coagulation and trace element examination.   With 17 years in research and production, Hubei New Desheng Material Technology Co.,ltd developed all kinds of blood collection tube additives like sodium heparin, lithium heparin, EDTA dipotassium,EDTA tripotassium,EDTA disodium.What we can provide is competitive price and good quality,welcome to inquiry.

Lithium heparin green tube is a blood collection tube for plasma collection in blood testing. Due to this kind of medical device has the effect of anti-coagulation, the plasma can be separated from the blood after blood collection.Except for the collection of plasma required for biochemical tests,it’s also used for subsequent cell culture experiments of blood cells such as lymphocytes after blood collection. However, this method cannot be used for the test items of white blood cell count and classification, which may lead to inaccurate test results. Lithium heparin blood collection tubes can mainly check liver diseases, such as viral hepatitis or liver cancer,liver abscesses and fatty livers. Lithium heparin is not a test items, but a anticoagulants. With the effect of antithrombin,lithium heparin are added to the blood collection tube with the green cap,which can prolong the coagulation time of the specimen. It is suitable for red blood cell fragility test, blood gas analysis, hematocrit test, erythrocyte sedimentation rate and general energy biochemical determination, but not suitable for blood coagulation test. There is a 3ml tubes with lithium heparin green tubes which is often used for lead detection in children.Lithium heparin green tube is a heparin anticoagulant tube.Heparin sodium was used in the past may influence the result of electrolyte measurement. After technical improvement,lithium heparin is generally used. It can be applied for most biochemical tests, such as serum potassium. Heparin anticoagulants are generally used for emergency laboratory tests, because they need to be centrifuged immediately after blood collection.The yellow or red test tubes need blood coagulation before centrifuging the serum, which will delay the emergency examination.In addition, the lithium heparin green tubes can also be used for trace element determination and blood flow experiments. The plasma separation tubes with light green cap, which is adding lithium heparin anticoagulant to the inert serum separation gel tube.This kind of tubes can separate plasma rapidly , and it is the best choice for electrolyte testing routine plasma biochemical testing and emergency plasma biochemical testing such as ICU. Plasma samples can be loaded directly on the machine and keep stable for 48 hours under refrigeration. Heparin anticoagulation tubes are applied to check four kinds of blood coagulation. It is a common inspection item in the laboratory department,generally to maintain the natural form of red blood cells.If this situation is detected, some traditional Chinese medicine can be used for conservative treatment. Hubei New Desheng Material Technology Co.,ltd is specialists for all kins of blood collection tube additives, which made from good quality of raw materials, welcome to inquity.

Most of tests in clinical chemistry, immunoassays are need to detect serum. After blood collection, it will coagulate naturally. Under the action of coagulation factors, fibrinogen is decomposed into fibrin filaments, which tightly surround blood cells to form blood clots, and a part of serum is precipitated.However, if the blood collection volume is insufficient, the precipitated serum cannot satisfy detection needs. Therefore, the serum separation gel produced to quickly and fully separate blood clots and serum or separate plasma from cells. The operation is simple and practical. Today, the editor of Desheng will briefly explain the problems that may occur in the use of serum separation gel,and our suggestions for them. In practical operation, there will be various problems related to the separation glue, such as the generation of air bubbles in the blood collection tubes, and the phenomenon of separation glue drawn a wire when added into tubes. The reasons and solutions for these problems are analyzed below. In the process of adding glue by machine or manually, the separation gel may contact with the air when it is injected into the bottom of the blood collection tube, resulting in the generation of air bubbles. Or the vacuum of the mixer is not enough, which will cause air to enter and form bubbles. This bubble will not affect the properties of separation gel. When bubbles appear, Desheng recommends centrifuging for 2 hours after adding glue. In addition, when the separation gel is sterilized by cobalt 60 irradiation, the temperature of the separation gel in the test tube can reach 80 °C. When the irradiation dose is too large, a great amount of heat is not discharged in time, and bubbles will also be formed. Desheng Company recommends that the irradiation dose should be controlled at 15-25kgy. The temperature of the serum separating glue in the PET tubes should be controlled at 40-50 °C, and the glass tubes should be controlled below 80 °C. Serum separation gel is a viscous fluid, and its viscosity varies with temperature. When the ambient temperature is low, it will difficult to add glue, and cause wire drawn phenomenon. At that time,Desheng recommends heating the separating gel to around 60-70 ℃ by hot water to reduce the viscosity. Increase the suction speed or break the wire by vibration are also can solve the problem. After years of research and development, Hubei New Desheng Material Technology Co., Ltd. has obtained an independent patent for serum separation gel. Cooperate with our company,we can provide you with more professional advices about serum separation gel. If necessary, please send inquire.

Today, Wuhan New Desheng Material Technology Co., Ltd. will introduce some common questions about the application of lithium heparin in blood collection tubes. FAQ 1: What does it check for blood collection tubes with lithium heparin? The normal applications of blood collection tubes with lithium heparin is blood rheology tests, blood cell volume tests and blood gas tests (Pls note: lithium heparin we produced are raw materials,it cannot do blood gas analysis). It also can be used for the detection after hemodialysis and other specific items such as arterial blood gas analysis, detection of electrolytes, calcium ions, etc. FAQ 2: What is the grade of lithium heparin applied in blood collection tubes? Lithium heparin applied in blood collection tubes need biochemical grade, like the powder we produced by Desheng. And the potency per milligram is greater than or equal to 150IU. FAQ 3: Do the blood collection tubes added with lithium heparin need to be dried? The blood collection tube added with lithium heparin must be completely dried, because lithium heparin is a mucopolysaccharide substance, which can easily breed bacteria in the tubes. FAQ 4: What is the normal operation after lithium heparin anti-coagulation tubes collecting blood samples? Under normal circumstances, the tubes with green cap is lithium heparin anti-coagulation tubes. In order to ensure sufficient blood anti-coagulation, it must be gently inverted and mixed 5 to 8 times as soon as possible after blood collection, otherwise the blood will coagulate. Vigorous can cause hemolysis with blood cells rupture. FAQ 5: Can lithium heparin be used with other blood collection tube additives? Lithium heparin can be used with sodium fluoride for blood glucose testing, and with serum separation gel for electrolyte testing,which is to check whether the content of electrolytes in the body is normal, mainly including potassium, sodium, calcium, magnesium, iron, phosphorus, etc. The activities and metabolism of biological cells must be carried out in a liquid state. Under normal circumstances, the fluctuation range of body fluids and components is small, so as to keep the volume, electrolyte, osmotic pressure, and pH of body fluids relatively stable. The above are answers for common questions that most people confuse about the application of lithium heparin in blood collection tubes. Hubei New Desheng Material Technology Co., Ltd. is a manufacturer for a series of blood collection tube additives. We have rich experience in R&D.Please feel free to inquire if you have any requirements.

Heparin sodium is a white or off-white powder with anticoagulant effect both in vivo and in vitro.It is odorless, easily soluble in water, and insoluble in organic solvents such as ethanol and acetone. It has a strong negative charge in aqueous solution and can combine with some cations to form molecular complexes. The solution of heparin sodium is relatively stable at PH 7.   There are many anti-coagulation mechanisms of heparin sodium applied in blood collection tubes, mainly by combining with antithrombin III (AT-III), inhibiting the action of coagulation factors, thereby preventing platelet aggregation and destruction, hindering the formation of thromboplastin, and preventing prothrombin from changing. It is thrombin, which prevents fibrinogen from becoming fibrin and exerts an anticoagulant effect.   Heparin sodium is often used in the collection and anti-coagulation of blood samples for clinical biochemical examinations and emergency biochemical examinations, and is also suitable for blood sample collection and anti-coagulation in some hemorheology projects.In addition to blood anti-coagulation, heparin sodium can also be used for drugs’ injection.   Heparin sodium is a mucopolysaccharide substance. After being prepared into a solution,it is easy to grow bacteria if it’s not used for a long time.Therefore, it should be used immediately after being prepared into a solution with deionized water or distilled water.Sealed and stored in a sterile state not exceed one week. Hubei New Desheng Material Technology Co., Ltd. recommends that the conventional dosage for disposable venous vacuum blood collection tubes is 5-20IU heparin sodium anti-coagulation with 1mL of blood , and 8-10IU heparin sodium anti-coagulation with 1ml blood for peripheral blood anti-coagulation. Heparin sodium on the market is generally extracted from small intestine of pigs with wide fresh supply source.The potency of heparin sodium produced by Desheng is 150IU/mg, and the anhydrous potency is 160IU/mg.The white powder obtained by refining and purification can maximize the accuracy of the experimental results.   The anti-coagulant effect is better if use heparin sodium and serum separation gel at the same time. The quality of the serum separation gel will affect the anti-coagulation effect of heparin sodium, so it is recommended to mix it with the anti-radiation separation gel produced by Desheng.

The full chemical name of MOPS buffer is 3-morpholinepropanesulfonic acid. It is a white crystalline powder at room temperature with good hydrophilicity. 10g of MOPS powder can be completely dissolved in 100ml of water at 20°C, and the dissolved solution is colorless and transparent.MOPS is often prepared as a zwitterionic biological buffer to adjust the pH of the solution in biochemical reactions. Specifications of MOPS: CAS No.:1132-61-2 Molecular Formula: C7H15NO4S Molecular Weight:209.3g/mol PH range:6.5-7.9 pKa(25℃):7.0-7.4 Purity:>=99% As a common buffer, MOPS buffer has a wide range of applications.Editor of Desheng will elaborate on several applications of MOPS buffers as following: 1. Since the pH range is between 6.5-7.9, MOPS buffer can be used to separate, purify, and extract RNA and protein, but cannot be used to separate DNA because it can interact with DNA and form complexes. 2. MOPS buffer can bind to iron, but does not react with most metals such as magnesium, manganese, cobalt, nickel, etc. Therefore,it is often added to stabilize the acidity of the solution in cell culture media that do not require iron ions, such as bacteria, charcoal yeast, and mammalian cells.It should be noted that the concentration of the buffer has a great influence on the PH of the solution, so when using the MOPS buffer to adjust the PH of the cell culture, the concentration of MOPS should be less than 20 mm. 3. In the non-denaturing agarose gel electrophoresis experiment of RNA, MOPS buffer is more suitable for stabilizing the pH value of the solution than other buffers. 4. Because the UV absorbance of MOPS buffer is very small, it does not interfere with the measurement of absorption during UV/Vis spectrophotometry. 5.At room temperature, the chemical properties of MOPS buffer are very stable. When it interacts with the peptide backbone of bovine serum albumin, it can promote the protein to reach a static stable state. MOPS buffer has a strong buffering capacity in the pH range of 6.5-7.9. The point should be noticed is that MOPS can change the interaction between lipids, such as affecting the thickness and barrier properties of the rat endothelial surface layer, the mRNA expression form of bovine embryos produced in vitro, etc.It can be oxidized by strong acids and strong alkali.Therefore,these substances should be avoided in application. Hubei New Desheng Material Technology Co., Ltd. is a professional manufacturer of biological buffers. The production process is stable and the appearance of the product is pure white crystal powder. Welcome to consult.

Carbomer produced by Hubei New Desheng is white loose powder with strong hygroscopicity. Therefore, it must be stored in a plastic bag at a dry place . When we use carbomer, it is usually made into gel and added into raw materials of daily chemicals or medicals.   What Influence the Characteristic of Carbomer Gel? 1. Carbomer gel properties are influenced by pH value With a large number of free carboxyl groups, the pKa value of carbomer polymers are usually small. If the PH of the medium is less than 4, the carboxyl groups are rarely separated, and if the PH is greater than 4, the carboxyl groups begin to separate, the polymer dissolves, and the viscosity increases.When PH reached 8, it is basically completely separated and the viscosity is the largest. The PH value of the medium also affects the adhesion of carbomer gels. When the pH value is lower than pKa, the binding ability of the gel is strong, and the adhesion will increase. At the same time, the ionic strength of the medium can change the sensitivity of the carbomer gel to pH value. When the ionic strength is high, the carbomer releases protons and decrease its pKa value, so it can be dissolved at a lower PH value.   2. Carbomer gel properties are influenced by ionic strength In some drugs, the effect of the drug on the PH and ionic strength of the medium around the gel cannot be ignored. The acidity of the drug also affects the properties of the gel, so the effect of acidic drugs is more pronounced.   3. Carbomer gel properties are influenced by other excipients The simultaneous use of polyvinylpyrrolidine and polyoxyethylene as auxiliary agents with carbomer gels can reduce the mucoadhesion of carbomer gels. The degree of reduction is related to the concentration and molecular weight of coexisting excipients. The high concentration over 5% of excipients can greatly reduce the adhesion of carbomer gel, and if the concentration is reduced to 0.5%, the effect is small. Generally, the PH value of the medium does not change this property of polyvinylpyrrole and polyoxyethylene. Magnesium stearate is hydrophobic,which also reduces the adhesion of carbomer gels.   Above is the detailed introduction of Hubei New Desheng Material Technology Co., Ltd. on the factors that affect the properties of carbomer gel. Hubei New Desheng Material Technology Co., Ltd. is a manufacturer specializing in the production of raw materials for biochemical testing and detection reagents, including carbomer 940 and 980 with chemical level. We provide guaranteed quality,welcome your consultation and understanding.